In the United States District Court for the Southern District of New York : United States of America, plaintiff v. Apple, Inc., Hachette Book Group, Inc., Harpercollins Publishers, L.L.C., Verlagsgruppe Georg von Holtzbrink Publlshers, LLC d/b/a/ Macmillan, the Penguin Group, a division of Pearson PLC, Penguin Group (USA), Inc. and Simon & Schuster, Inc., defendants : civil action no.12-CV-2826 (DLC) / brief of Bob Kohn as amicus curiae.

A lawyer, [Bob Kohn], who opposes the Justice Department’s proposed antitrust settlement with three publishers of e-books has filed an amicus brief ... in the form of a comic strip ... He opted for the unusual format after U.S. District Judge Denise Cote of Manhattan limited his brief to five pages ... The U.S. Justice Department filed suit in April against Apple and five publishers claiming a conspiracy to address Amazon.com’s low e-book pricing of $9.99 that was often below its cost. The DOJ saw a price-fixing conspiracy, while supporters said Amazon’s low prices were killing off competition and allowing it to gain market share. -- Debra Cassens Weiss, ABA journal Sep 05, 2012. http://morris.law.yale.edu/record=b1508429https://digitalcommons.law.yale.edu/amtrials/1020/thumbnail.jp

The Ursinus Weekly, October 26, 1964

Play, varied activities termed success at retreat: Play forms discussion springboard • Senior Prom to feature Raymond band, Camelot • Democrats sweep campus with 57 percent majority: Partisan area shows Johnson strength • Library consultant to discuss career opportunities • Ursinus to honor four alumni in Founders\u27 Day ceremonies: Helfferich\u27s address, college\u27s future • Dooley associate to speak, show film in Y forum • Parents flock to campus in annual festivities: Grid loss dampens day only a little • Election planned to fill WSGA senate vacancies • Editorial: Answering critics • Is the Summer reading program worthless? • New Gym Club forms on campus • Presidential candidates discussed in debate • Library service expanding • Sophomores elect Atkinson, MSGA representative • Letters to the editor • UC gridmen massacred 48-0 by winless Swarthmore foe: Degenhardt, Moser and Videon on injured list • Day students and Demas win titles • Bear booters beat both Delaware and PMC 1-0 • Pfahler film circus: What to do • Advice column • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1231/thumbnail.jp

Measuring student teachers' basic psychological needs

In the Self-Determination Theory (SDT) basic psychological needs for relatedness, autonomy and competence are distinguished. Basic psychological need fulfilment is considered to be critical for human development and intrinsic motivation. In the Netherlands, the concept of basic psychological need fulfilment is introduced in the curricula of many teacher education institutes. In five teacher education institutes for primary school teachers, study coaches use a Dutch version of the Basic Psychological Needs Scale (BPNS), to collect data to be used in a discussion with student teachers about their intrinsic motivation for a specific part of the teacher education course. On the basis of the outcomes of this discussion, study coaches and student teachers derive consequences for day to day practice in their classrooms. The data were also used to establish whether the theoretical distinction between three basic psychological needs is found in this sample of student teachers in the Netherlands. The results show that the constructs of relatedness, autonomy and competence are found and can be measured by using a 14-item five-point scale, partly based on the original BPNS, and partly on new items that focus on different sources of perceived need fulfilment, namely teacher education in general, the study coach and fellow students

recommendations from the CVBD World Forum

The human-animal bond has been a fundamental feature of mankind's history for millennia. The first, and strongest of these, man's relationship with the dog, is believed to pre-date even agriculture, going back as far as 30,000 years. It remains at least as powerful today. Fed by the changing nature of the interactions between people and their dogs worldwide and the increasing tendency towards close domesticity, the health of dogs has never played a more important role in family life. Thanks to developments in scientific understanding and diagnostic techniques, as well as changing priorities of pet owners, veterinarians are now able, and indeed expected, to play a fundamental role in the prevention and treatment of canine disease, including canine vector-borne diseases (CVBDs).The CVBDs represent a varied and complex group of diseases, including anaplasmosis, babesiosis, bartonellosis, borreliosis, dirofilariosis, ehrlichiosis, leishmaniosis, rickettsiosis and thelaziosis, with new syndromes being uncovered every year. Many of these diseases can cause serious, even life-threatening clinical conditions in dogs, with a number having zoonotic potential, affecting the human population.Today, CVBDs pose a growing global threat as they continue their spread far from their traditional geographical and temporal restraints as a result of changes in both climatic conditions and pet dog travel patterns, exposing new populations to previously unknown infectious agents and posing unprecedented challenges to veterinarians.In response to this growing threat, the CVBD World Forum, a multidisciplinary group of experts in CVBDs from around the world which meets on an annual basis, gathered in Nice (France) in 2011 to share the latest research on CVBDs and discuss the best approaches to managing these diseases around the world.As a result of these discussions, we, the members of the CVBD Forum have developed the following recommendations to veterinarians for the management of CVBDs

Vector-Borne Diseases - constant challenge for practicing veterinarians: recommendations from the CVBD World Forum

The human-animal bond has been a fundamental feature of mankind's history for millennia. The first, and strongest of these, man's relationship with the dog, is believed to pre-date even agriculture, going back as far as 30,000 years. It remains at least as powerful today. Fed by the changing nature of the interactions between people and their dogs worldwide and the increasing tendency towards close domesticity, the health of dogs has never played a more important role in family life. Thanks to developments in scientific understanding and diagnostic techniques, as well as changing priorities of pet owners, veterinarians are now able, and indeed expected, to play a fundamental role in the prevention and treatment of canine disease, including canine vector-borne diseases (CVBDs)

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Neuroinflammation and microglial activation are significant processes in Alzheimer’s disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes in association with Alzheimer’s disease, and experimental data have demonstrated microglial proliferation as a significant component of the neuropathology. In this study, we tested the efficacy of the selective CSF1R inhibitor JNJ-40346527 (JNJ-527) in the P301S mouse tauopathy model. We first demonstrated the anti-proliferative effects of JNJ-527 on microglia in the ME7 prion model, and its impact on the inflammatory profile, and provided potential CNS biomarkers for clinical investigation with the compound, including pharmacokinetic/pharmacodynamics and efficacy assessment by TSPO autoradiography and CSF proteomics. Then, we showed for the first time that blockade of microglial proliferation and modification of microglial phenotype leads to an attenuation of tau-induced neurodegeneration and results in functional improvement in P301S mice. Overall, this work strongly supports the potential for inhibition of CSF1R as a target for the treatment of Alzheimer’s disease and other tau-mediated neurodegenerative diseases

Inflammatory biomarkers in Alzheimer's disease plasma

Introduction:Plasma biomarkers for Alzheimer’s disease (AD) diagnosis/stratification are a“Holy Grail” of AD research and intensively sought; however, there are no well-established plasmamarkers.Methods:A hypothesis-led plasma biomarker search was conducted in the context of internationalmulticenter studies. The discovery phase measured 53 inflammatory proteins in elderly control (CTL;259), mild cognitive impairment (MCI; 199), and AD (262) subjects from AddNeuroMed.Results:Ten analytes showed significant intergroup differences. Logistic regression identified five(FB, FH, sCR1, MCP-1, eotaxin-1) that, age/APOε4 adjusted, optimally differentiated AD andCTL (AUC: 0.79), and three (sCR1, MCP-1, eotaxin-1) that optimally differentiated AD and MCI(AUC: 0.74). These models replicated in an independent cohort (EMIF; AUC 0.81 and 0.67). Twoanalytes (FB, FH) plus age predicted MCI progression to AD (AUC: 0.71).Discussion:Plasma markers of inflammation and complement dysregulation support diagnosis andoutcome prediction in AD and MCI. Further replication is needed before clinical translatio

The Legal Battle on Personhood Debate

The Federalist Society and Student Animal Legal Defense Fund present a debate between leaders in the field of personhood rights for animals. Moderated by Professor Joseph Richard Hurt with introductions by Professor Randall S. Abate, this debate is A Must See Event of Legal Heavyweights!https://commons.law.famu.edu/lectures-debates/1000/thumbnail.jp

Public squares in European city centres

During the latter part of the twentieth century, while a small number of exemplar city centre squares continued to be attractive places, the vast majority acquired either an image of empty spaces or an unattractive picture as traffic islands. This was emphasised by the decline of traditional community activities and the perception of comfort generated by internalising external space; coupled with a commodifying of cities in which they were merely viewed as commercial and retail opportunities. Communities need public spaces as places for assembly. They are the physical manifestation that each community is coherent and vibrant. Increasingly, it is being recognised that identity and place have enormous roles in reinforcing society. The re-introduction of public squares is part of reversing the erosion of the public sector and the public realm, and reclaiming city centres from private interests for the benefit of communities. Criteria for comfortable external spaces have been researched, and these recognise the differences between Northern and Southern Europe. The most recent advances are in the simulation of city centre design; which includes geometry, uses, pedestrian movement and environmental conditions. There is confidence to be gained from visualisation of how squares will look, feel and be used; and will make a real contribution to sustainable urban design