Citra Penjajahan Jepang di Indonesia yang Terpantul dalam Beberapa Novel Pramoedya

Images of Japanese troops which drawn by Pramoedya in his works indeed related with his own experiences. Pramoedya through his characters portrays his view on humanities. Pramoedya depicted the brutality of Japanese troops in their occupation in Indonesia. All Japanese propaganda delivered false messages and caused disasters for Indonesian people. Japanese culture retardation and their brutality made the author suffer and down. Even though his novels associate with anti Japanese occupation and patriotism among the youth, humanities issues in fact appear as a strong theme in all his works

Promises of the "Book of Hope" : influences on the new Malaysian government

For more about the East-West Center, see http://www.eastwestcenter.org/Tommy K. S. Koh, former Summer Affiliate Scholar at the East-West Center, explains that "Written as an opposition manifesto, Buku Harapan's desire for greater parliamentary engagement reflected what Pakatan Harapan desired from an expected ruling Barisan Nasional government.

The role of type 4 phosphodiesterases in generating microdomains of cAMP: Large scale stochastic simulations

Cyclic AMP (cAMP) and its main effector Protein Kinase A (PKA) are critical for several aspects of neuronal function including synaptic plasticity. Specificity of synaptic plasticity requires that cAMP activates PKA in a highly localized manner despite the speed with which cAMP diffuses. Two mechanisms have been proposed to produce localized elevations in cAMP, known as microdomains: impeded diffusion, and high phosphodiesterase (PDE) activity. This paper investigates the mechanism of localized cAMP signaling using a computational model of the biochemical network in the HEK293 cell, which is a subset of pathways involved in PKA-dependent synaptic plasticity. This biochemical network includes cAMP production, PKA activation, and cAMP degradation by PDE activity. The model is implemented in NeuroRD: novel, computationally efficient, stochastic reaction-diffusion software, and is constrained by intracellular cAMP dynamics that were determined experimentally by real-time imaging using an Epac-based FRET sensor (H30). The model reproduces the high concentration cAMP microdomain in the submembrane region, distinct from the lower concentration of cAMP in the cytosol. Simulations further demonstrate that generation of the cAMP microdomain requires a pool of PDE4D anchored in the cytosol and also requires PKA-mediated phosphorylation of PDE4D which increases its activity. The microdomain does not require impeded diffusion of cAMP, confirming that barriers are not required for microdomains. The simulations reported here further demonstrate the utility of the new stochastic reaction-diffusion algorithm for exploring signaling pathways in spatially complex structures such as neurons

Public Health Leadership In The 21st Century

Leadership in public health requires stretching the mind and soul in almost unimaginable ways. Living the dynamic tension of health as “part individual good served by medicine and part public good secured by public health activities” (Institute of Medicine, 2003a) represents a privilege and an awesome responsibility. Upholding the health of others requires complementing a foundation in science with skills in government, policy, media, economics, sociology, ethics and other dimensions. To survive and thrive, public health leaders must practice the “tactics of the transcendent” (Parks, 2005)

Exercise Attenuated Plasma Oxidized Low-density Lipoprotein and Myeloperoxidase

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