1,062 research outputs found
Fast Mesh Refinement in Pseudospectral Optimal Control
Mesh refinement in pseudospectral (PS) optimal control is embarrassingly easy
--- simply increase the order of the Lagrange interpolating polynomial and
the mathematics of convergence automates the distribution of the grid points.
Unfortunately, as increases, the condition number of the resulting linear
algebra increases as ; hence, spectral efficiency and accuracy are lost in
practice. In this paper, we advance Birkhoff interpolation concepts over an
arbitrary grid to generate well-conditioned PS optimal control discretizations.
We show that the condition number increases only as in general, but
is independent of for the special case of one of the boundary points being
fixed. Hence, spectral accuracy and efficiency are maintained as increases.
The effectiveness of the resulting fast mesh refinement strategy is
demonstrated by using \underline{polynomials of over a thousandth order} to
solve a low-thrust, long-duration orbit transfer problem.Comment: 27 pages, 12 figures, JGCD April 201
BD-22 3467, a DAO-type star exciting the nebula Abell 35
Spectral analyses of hot, compact stars with NLTE (non-local thermodynamical
equilibrium) model-atmosphere techniques allow the precise determination of
photospheric parameters. The derived photospheric metal abundances are crucial
constraints for stellar evolutionary theory.
Previous spectral analyses of the exciting star of the nebula A 35, BD-22
3467, were based on He+C+N+O+Si+Fe models only. For our analysis, we use
state-of-the-art fully metal-line blanketed NLTE model atmospheres that
consider opacities of 23 elements from hydrogen to nickel. For the analysis of
high-resolution and high-S/N (signal-to-noise) FUV (far ultraviolet, FUSE) and
UV (HST/STIS) observations, we combined stellar-atmosphere models and
interstellar line-absorption models to fully reproduce the entire observed UV
spectrum.
The best agreement with the UV observation of BD-22 3467 is achieved at Teff
= 80 +/- 10 kK and log g =7.2 +/- 0.3. While Teff of previous analyses is
verified, log g is significantly lower. We re-analyzed lines of silicon and
iron (1/100 and about solar abundances, respectively) and for the first time in
this star identified argon, chromium, manganese, cobalt, and nickel and
determined abundances of 12, 70, 35, 150, and 5 times solar, respectively. Our
results partially agree with predictions of diffusion models for DA-type white
dwarfs. A combination of photospheric and interstellar line-absorption models
reproduces more than 90 % of the observed absorption features. The stellar mass
is M ~ 0.48 Msun.
BD-22 3467 may not have been massive enough to ascend the asymptotic giant
branch and may have evolved directly from the extended horizontal branch to the
white dwarf state. This would explain why it is not surrounded by a planetary
nebula. However, the star, ionizes the ambient interstellar matter, mimicking a
planetary nebula.Comment: 13 pages, 17 figure
Astrocytic Ephrin-B1 Regulates Synapse Remodeling Following Traumatic Brain Injury.
Traumatic brain injury (TBI) can result in tissue alterations distant from the site of the initial injury, which can trigger pathological changes within hippocampal circuits and are thought to contribute to long-term cognitive and neuropsychological impairments. However, our understanding of secondary injury mechanisms is limited. Astrocytes play an important role in brain repair after injury and astrocyte-mediated mechanisms that are implicated in synapse development are likely important in injury-induced synapse remodeling. Our studies suggest a new role of ephrin-B1, which is known to regulate synapse development in neurons, in astrocyte-mediated synapse remodeling following TBI. Indeed, we observed a transient upregulation of ephrin-B1 immunoreactivity in hippocampal astrocytes following moderate controlled cortical impact model of TBI. The upregulation of ephrin-B1 levels in hippocampal astrocytes coincided with a decline in the number of vGlut1-positive glutamatergic input to CA1 neurons at 3 days post injury even in the absence of hippocampal neuron loss. In contrast, tamoxifen-induced ablation of ephrin-B1 from adult astrocytes in ephrin-B1(loxP/y)ERT2-Cre(GFAP) mice accelerated the recovery of vGlut1-positive glutamatergic input to CA1 neurons after TBI. Finally, our studies suggest that astrocytic ephrin-B1 may play an active role in injury-induced synapse remodeling through the activation of STAT3-mediated signaling in astrocytes. TBI-induced upregulation of STAT3 phosphorylation within the hippocampus was suppressed by astrocyte-specific ablation of ephrin-B1 in vivo, whereas the activation of ephrin-B1 in astrocytes triggered an increase in STAT3 phosphorylation in vitro. Thus, regulation of ephrin-B1 signaling in astrocytes may provide new therapeutic opportunities to aid functional recovery after TBI
A Priori and a Posteriori Dietary Patterns in Women of Childbearing Age in the UK.
Poor diet quality is a major cause of maternal obesity. We aimed to investigate a priori and a-posteriori derived dietary patterns in childbearing-aged women in UK. An online survey assessed food intake, physical activity (PA), anthropometry and socio-demographics. An a priori defined diet quality was determined via Mediterranean diet (MD) adherence score and Exploratory Factor Analysis (EFA) derived dietary patterns (DPs). Multiple linear regression explored associations between DPs with anthropometric measures, PA and socio-demographics. Participants (n = 123) had low-to-medium MD adherence (average MD-score: 4.0 (2.0)). Age was positively associated with higher MD adherence (X2 (2) = 13.14, p = 0.01). EFA revealed three DPs: 'fruits, nuts, vegetables and legumes' ("Vegetarian-style" DP); 'sweets, cereals, dairy products and potatoes' ("Dairy, sweets and starchy foods" DP); and 'eggs, seafood and meats' ("Protein-rich" DP). "Vegetarian-style" DP was positively associated with higher maternal educational level (p < 0.01) and PA (p = 0.01), but negatively with white ethnicity (p < 0.01). "Dairy, sweets and starchy foods" DP was positively associated with white ethnicity (p = 0.03) and negatively with age (p = 0.03). "Protein-rich" DP was positively associated with age (p < 0.001) and negatively with PA (p = 0.01). A poor diet quality was found among childbearing-aged women; notably in the younger age category, those of white ethnicity, that were more physically inactive and with a lower socioeconomic background
Cellular, molecular and functional characterisation of YAC transgenic mouse models of Friedreich Ataxia
Copyright © 2014 Anjomani Virmouni et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.This article has been made available through the Brunel Open Access Publishing Fund.Background - Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder, caused by a GAA repeat expansion mutation within intron 1 of the FXN gene. We have previously established and performed preliminary characterisation of several human FXN yeast artificial chromosome (YAC) transgenic FRDA mouse models containing GAA repeat expansions, Y47R (9 GAA repeats), YG8R (90 and 190 GAA repeats) and YG22R (190 GAA repeats).
Methodology/Principal Findings - We now report extended cellular, molecular and functional characterisation of these FXN YAC transgenic mouse models. FXN transgene copy number analysis of the FRDA mice demonstrated that the YG22R and Y47R lines each have a single copy of the FXN transgene while the YG8R line has two copies. Single integration sites of all transgenes were confirmed by fluorescence in situ hybridisation (FISH) analysis of metaphase and interphase chromosomes. We identified significant functional deficits, together with a degree of glucose intolerance and insulin hypersensitivity, in YG8R and YG22R FRDA mice compared to Y47R and wild-type control mice. We also confirmed increased somatic GAA repeat instability in the cerebellum and brain of YG22R and YG8R mice, together with significantly reduced levels of FXN mRNA and protein in the brain and liver of YG8R and YG22R compared to Y47R.
Conclusions/Significance - Together these studies provide a detailed characterisation of our GAA repeat expansion-based YAC transgenic FRDA mouse models that will help investigations of FRDA disease mechanisms and therapy.European Union, Ataxia UK and FARA
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