THE DEVICE FOR TRAINING BREATHING OF SWIMMERS USING OF PNEUMA·VIBRATION

The development of new technologies of preparation of swimmers is one from major problems. The solution of this problem is possible at the expense application of special devices ensuring increase of efficiency of competitive exercise. Majorities of technical devices for preparation of swimmers are used for increase of special fitness of sportsmen. At the same time growth of sports results is possible at the expense of teleological effect on functional systems of an organism of the sportsmen. The device using of pneumavibration effect for training a respiratory system of swimmers in real swimming is offered. The offered device allows to increase volume of training work executed by swimmers in a specific space of time for simultaneous growth of adaptive possibilities of a swimmer's organism and to decrease the restoring time after the intensive training work

Biodegradable Nanocarriers Resembling Extracellular Vesicles Deliver Genetic Material with the Highest Efficiency to Various Cell Types

Efficient delivery of genetic material to primary cells remains challenging. Here, efficient transfer of genetic material is presented using synthetic biodegradable nanocarriers, resembling extracellular vesicles in their biomechanical properties. This is based on two main technological achievements: generation of soft biodegradable polyelectrolyte capsules in nanosize and efficient application of the nanocapsules for co‐transfer of different RNAs to tumor cell lines and primary cells, including hematopoietic progenitor cells and primary T cells. Near to 100% efficiency is reached using only 2.5 × 10−4 pmol of siRNA, and 1 × 10−3 nmol of mRNA per cell, which is several magnitude orders below the amounts reported for any of methods published so far. The data show that biodegradable nanocapsules represent a universal and highly efficient biomimetic platform for the transfer of genetic material with the utmost potential to revolutionize gene transfer technology in vitro and in vivo

Study of the influence of thermodynamic processes on the parameters of the technical condition of power plants

The article substantiates the need to consider the dependence of the external characteristics of transport power plants on the parameters of thermodynamic processes in the combustion chambers of heat engines. The results of theoretical and experimental studies are presented. They prove the influence of the technical condition on the thermodynamic parameters of diesel internal combustion engines. Expressions are presented that describe the thermodynamic processes of power plants from the point of view of the relationship between the mechanical and thermodynamic components of torque. It is shown that the temperature of the working surfaces of a diesel engine is an important characteristic of its technical condition. The results of experimental studies of the influence of the temperature of the cylinder liner wall, which determines the rate of evaporation of the oil film between the piston and the cylinder liner, on the amount of engine oil consumption for waste under various technical conditions of the diesel engine are presented. It has been shown that reducing engine temperature can help reduce oil consumption in internal combustion engines

Stabilizers for functional copper nanomaterials for triboengineering

The formation of complexes of nitrogenated molecules with a small copper cluster Cun (n=1-7, 13) is systematically studied through the calculations by the density functional theory method. It is shown that the molecules of R1N=Y (Y=CR2R3, NR2, O) are promising for searching agents for copper clusters, as they are synthetically-available, can exert reducing properties, are firmly bound to the copper atoms, and do not distort the original cluster structure. Using any bulky substituent R, it is possible to block access to a large surface area of the cluster for aggressive compounds. Oxygen complexes on the surface of the copper cluster drastically fall short of the strength of the structures formed by molecules R1N=Y (Y=CR2R3, NR2, O). Depending on the cluster size, the interaction force varies in a sinusoidal manner from minimum to maximum

Biodegradable nanocarriers resembling extracellular vesicles deliver genetic material with the highest efficiency to various cell types

Abstract Efficient delivery of genetic material to primary cells remains challenging. Here, efficient transfer of genetic material is presented using synthetic biodegradable nanocarriers, resembling extracellular vesicles in their biomechanical properties. This is based on two main technological achievements: generation of soft biodegradable polyelectrolyte capsules in nanosize and efficient application of the nanocapsules for co‐transfer of different RNAs to tumor cell lines and primary cells, including hematopoietic progenitor cells and primary T cells. Near to 100% efficiency is reached using only 2.5 × 10–4 pmol of siRNA, and 1 × 10–3 nmol of mRNA per cell, which is several magnitude orders below the amounts reported for any of methods published so far. The data show that biodegradable nanocapsules represent a universal and highly efficient biomimetic platform for the transfer of genetic material with the utmost potential to revolutionize gene transfer technology in vitro and in vivo