Heat Map with Hierarchical Clustering: Multivariate Visualization Method for Corpus-based Language Studies

東洋大学Toyo Universityコーパスに基づく言語研究の利点は，広範な言語項目を分析対象とすることで，言語データを包括的に記述できることである。しかしながら，複数のデータにおける多数の言語項目を効率的に分析するためには，多変量解析などの統計手法に関する知識が求められる。本稿では，言語研究で活用することができる複数の多変量解析の長所と短所を比較検討し，ヒートマップと階層型クラスター分析を組み合わせて用いることの有効性を論じる。それに加えて，R言語を用いた解析方法と，その解析結果を解釈する方法を提示する。An advantage of corpus-based language studies is that global descriptions of linguistic texts can be obtained by examining a broad range of linguistic features. However, multivariate statistical techniques are required to analyze the multiple linguistic features found in a number of texts. This study compared the strengths and weaknesses of several multivariate statistical techniques, thereby demonstrating the effectiveness of using heat map with hierarchical clustering as a powerful method for visualizing multivariate data. Explanations are also provided for how these techniques can be used in the R programming language as well as indicating how the results obtained can be interpreted

Structural basis for the membrane association of ankyrinG via palmitoylation

Fujiwara, Y., Kondo, H., Shirota, M. et al. Structural basis for the membrane association of ankyrinG via palmitoylation. Sci Rep 6, 23981 (2016) doi:10.1038/srep2398

Fabrication of Planar Power Inductor for Embedded Passives in LSI Package for Hundreds Megahertz Switching DC–DC Buck Converter

Recently, research and development of integrated low-voltage dc-dc converter to LSIs has been active. In order to realize such integrated dc power supply, power magnetic devices must be integrated in it. The authors have fabricated planar power inductor embedded in LSI package for hundreds megahertz switching dc-dc buck converter. In this study, two types of planar power inductors have been fabricated: one was spin-sprayed Zn-ferrite thick film magnetic core inductor, and the other was composite magnetic core (Fe-based amorphous/polyimide) inductor. Footprint of the fabricated inductors was 850 x 850 mu m(2), their inductance was about 10 nH, and the quality factor Q was about 20 at 100 MHz. The rating current which depends on the superimposed dc characteristic was at least up to 2 A.ArticleIEEE TRANSACTIONS ON MAGNETICS. 47(10):3204-3207 (2011)journal articl

Presence of Cartilage Stem/Progenitor Cells in Adult Mice Auricular Perichondrium

BACKGROUND: Based on evidence from several other tissues, cartilage stem/progenitor cells in the auricular cartilage presumably contribute to tissue development or homeostasis of the auricle. However, no definitive studies have identified or characterized a stem/progenitor population in mice auricle. METHODOLOGY/PRINCIPAL FINDINGS: The 5-bromo-2'-deoxyuridine (BrdU) label-retaining technique was used to label dividing cells in fetal mice. Observations one year following the labeling revealed that label-retaining cells (LRCs) were present specifically in auricular perichondrium at a rate of 0.08±0.06%, but LRCs were not present in chondrium. Furthermore, LRCs were successfully isolated and cultivated from auricular cartilage. Immunocytochemical analyses showed that LRCs express CD44 and integrin-α(5). These LRCs, putative stem/progenitor cells, possess clonogenicity and chondrogenic capability in vitro. CONCLUSIONS/SIGNIFICANCE: We have identified a population of putative cartilage stem/progenitor cells in the auricular perichondrium of mice. Further characterization and utilization of the cell population should improve our understanding of basic cartilage biology and lead to advances in cartilage tissue engineering and novel therapeutic strategies for patients with craniofacial defects, including long-term tissue restoration

Fabrication of Planar Power Inductor for Embedded Passives in LSI Package for Hundreds Megahertz Switching DC-DC Buck Converter

Recently, research and development of integrated low-voltage dc-dc converter to LSIs has been active. In order to realize such integrated dc power supply, power magnetic devices must be integrated in it. The authors have fabricated planar power inductor embedded in LSI package for hundreds megahertz switching dc-dc buck converter. In this study, two types of planar power inductors have been fabricated: one was spin-sprayed Zn-ferrite thick film magnetic core inductor, and the other was composite magnetic core (Fe-based amorphous/polyimide) inductor. Footprint of the fabricated inductors was 850 x 850 mu m(2), their inductance was about 10 nH, and the quality factor Q was about 20 at 100 MHz. The rating current which depends on the superimposed dc characteristic was at least up to 2 A.ArticleIEEE TRANSACTIONS ON MAGNETICS. 47(10):3204-3207 (2011)journal articl

Exploring the Effectiveness of Combined Web-based Corpus Tools for Beginner EFL DDL

The purpose of this study is to investigate the effectiveness of combining two newly developed web-based tools for the foreign language DDL classroom. One is a KWIC concordance tool, WebParaNews, and the other is a lexical profiling tool, the LagoWordProfiler. Both are freeware and are based on the same parallel corpus, ParaNews, which consists of newspaper texts in English along with their aligned translations in Japanese. Using the same syllabus to teach various types of noun phrases for ten weeks, only one tool was used with the 2013 group, and both of the two tools were used in combination with the 2014 group. In order to reconfirm the effectiveness of combining two tools, both of the two tools were also used in 2015 group. In each year the teaching effect was measured using a pre- and post-test, and students’ feedback was collected using a 31-item questionnaire. Groups using both tools performed better than the single tool group on the gain between the pre- and post-test and gave more positive student feedback. This combined-resource approach using different types of information from two corpus tools may be more helpful for understanding the targeted grammar items than a more traditional single tool approach

Transient improvement of urticaria induces poor adherence as assessed by Morisky Medication Adherence Scale-8.

Poor adherence to medication is a major public health challenge. Here, we aimed to determine the adherence to oral and topical medications and to analyze underlying associated factors using the translated Japanese version of Morisky Medication Adherence Scale-8 regarding urticaria treatment. Web-based questionnaires were performed for 3096 registered dermatological patients, along with a subanalysis of 751 registered urticaria patients in this study. The adherence to oral medication was significantly associated with the frequency of hospital visits. Variables that affected the adherence to topical medication included age and experience of drug effectiveness. The rate of responses that "It felt like the symptoms had improved" varied significantly among the dermatological diseases treated with oral medications. Dermatologists should be aware that adherence to the treatment of urticaria is quite low. Regular visits and active education for patients with urticaria are mandatory in order to achieve a good therapeutic outcome by increasing the adherence