Influence of optical clearing on collagen crosslinking of sclera

The dynamics of the change of dimensions (cross-section area) of porcine sclera specimens in the process of optical clearing was measured using optical coherence tomography (OCT). Based on the obtained data, the optimal (corresponding to maximum tissue contraction) time interval between the application of the immersion agent and UV/riboflavin photo-crosslinking was found. The ability of multiphoton microscopy (tomography) to detect morphological changes in scleral tissue subjected to UV/riboflavin crosslinking in optically cleared state (with subsequent rehydration) was discussed based on measured BSHG images of UV/riboflavin treated porcine sclera ex vivo

Characteristics of changes and clinical and instrumental predictors of the severity of structural remodelling of carotid arteries in hypertensive patients

Background. Mechanisms of activation of the process of vascular wall remodelling in patients affected by arterial hypertension have not been studied in depth and require clarification. Materials and methods. The study included 381 patients with hypertension — 212 men and 169 women of the average age 53.0 (47; 60) years. The structural-functional vessel status was determined by the method of duplex scanning and colour duplex mapping of blood flow with the Logiq 500 MO apparatus (GE, USA). Statistical analyses were made using Microsoft Excel software kit, Statistica for Windows 6.0. Results. The patients with hypertension presented some left-right asymmetry of remodelling extracranial carotid arteries. Unlike the impact of remodelling of the right carotid artery, the most essential effect on the left carotid artery was the impact of daytime pulse arterial pressure and variability of the nocturnal systolic arterial pressure (the strength of impact 25.0 and 13.9%, respectively. The processes of remodelling of the right carotid artery are more sensible to the impact of high values of nocturnal diastolic arterial pressure (the strength of impact 16.4%). The beginning of some brain complication is associated with the significant increase in atherosclerotic affection not only of the left, but also of the right carotid artery. Conclusions. Remarkable remodelling of the right carotid artery is often associated with the severity of the disease and to some extent reflects the severity of the flow of the disease and can be regarded as an additional unfavourable feature

Possibilities of laser spectroscopy for monitoring the profile dynamics of the volatile metabolite in exhaled air

In this work we studied applicability of the laser spectroscopy for fixing differences in composition of exhaled air depending on the position of the body in different physical states. Using principal component analysis we show that the use of the laser spectroscopy methods is sufficiently effective to solve this problem and provide additional opportunities for the comprehensive study of the human condition

Investigation of the electric field distribution in the human brain based on MRI and EEG data

This work is devoted to the development of the approach to restoration of the spatial-temporal distribution of electric field in the human brain. This field was estimated from the model derived from the Maxwell’s equations with boundary conditions corresponding to electric potentials at the EEG electrodes, which are located on the surface of the head according to the standard “10-20” scheme. The MRI data were used for calculation of the spatial distribution of the electrical conductivity of biotissues in the human brain. The study of the electric field distribution using our approach was carried out for the healthy child and the child with autism. The research was carried out using the equipment of the Tomsk Regional Common Use Center of Tomsk State University

Creation of a magnetic driven gate for THz rays

In this paper, magnetic fluids based on iron oxide Fe3O4 and 5BDSR alloy were obtained. Magnetic particles were obtained by nanosecond pulsed laser ablation. The preparation of the magnetic fluid was carried out by mechanical and ultrasonic stirring in a solution of polymethylphenylsiloxane. It is shown that under the influence of an external magnetic field, the spectral properties of the magnetic fluid of the 5BDSR alloy correspond to characteristics that can be used to create a magnetic gate

Investigation of glycation products by THz time-domain spectroscopy

Glycation is the non-enzymatic reaction betwee

Charakterystyka zmian oraz klinicznych i instrumentalnych czynników prognostycznych ciężkości przebudowy strukturalnej tętnic szyjnych u pacjentów z nadciśnieniem

Wstęp. Mechanizmy aktywacji procesu przebudowy ścian naczyń u pacjentów chorujących na nadciśnienie tętnicze nie były dogłębnie zbadane i wymagają wyjaśnienia. Materiał i metody. Badaniem objęto 381 pacjentów z nadciśnieniem tętniczym — 212 mężczyzn i 169 kobiet w średnim wieku 53,0 (47; 60) lat. Stan strukturalno- funkcjonalny naczyń określono, stosując metodę badania za pomocą skanowania dupleksowego oraz kolorowego mapowania dupleksowego przepływu krwi za pomocą urządzenia Logiq 500 MO (GE, USA). Wykonano analizy statystyczne za pomocą zestawu oprogramowania Microsoft Excel, Statistica dla Windows 6.0. Wyniki. Pacjenci z nadciśnieniem tętniczym wykazywali pewną asymetrię lewo- i prawostronną przebudowy tętnic szyjnych zewnątrzczaszkowych. Inaczej niż w przypadku przebudowy prawej tętnicy szyjnej, na lewą tętnicę szyjną wpływały wartość ciśnienia tętniczego pulsu dziennego oraz zmienność nocnego skurczowego ciśnienia tętniczego (siła oddziaływania odpowiednio 25,0 i 13,9%). Procesy przebudowy prawej tętnicy szyjnej są bardziej wrażliwe na wpływ wysokich wartości nocnego rozkurczowego ciśnienia tętniczego (siła oddziaływania 16,4%). Początek pewnych komplikacji związanych z mózgiem wiąże się ze znacznym wzrostem choroby miażdżycowej nie tylko lewej, ale także prawej tętnicy szyjnej. Wnioski. Znaczna przebudowa prawej tętnicy szyjnej jest często związana z ciężkością choroby i do pewnego stopnia odzwierciedla ciężkość przebiegu choroby i może być postrzegana jako dodatkowa niekorzystna cecha