The economics of irrigating wheat in a humid climate - A study in the East of England

In the UK, wheat is the most important cultivated cereal, grown extensively as a rainfed crop. Irrigation of wheat has previously been considered uneconomic, but increases in world wheat prices and recent droughts have led to some farmers revising their views. Widespread adoption of wheat irrigation would have major implications for wheat production, the irrigation industry and water resources in regions that are already water scarce. This study investigated the financial viability of irrigating winter wheat grown on a sandy loam soil in the East of England. Long-term climate data (1961–2011) for Silsoe (Bedfordshire) was used to drive a biophysical crop model to assess irrigation water requirements and yield response. Modelling assumed a typical irrigation schedule to maximise yield and quality, and average reported wheat prices for 2007 to 2012. Irrigation costs were calculated assuming an overhead mobile hosereel–raingun system applying river water, abstracted either in summer and used directly, or abstracted in winter and stored in an on-farm reservoir. The results suggest that the yield benefit would justify supplemental irrigation by farmers who have unused irrigation equipment and unused summer water, although irrigation of higher-value field vegetable crops later in the season would normally take precedence – the Added Value of Water (AVW) usefully applied to milling winter wheat under these conditions ranged between 0.24 and 0.32 £ m−3. Investment in new irrigation schemes could also be marginally viable if unused summer river water was available for direct abstraction (AVW = 0.08 £ m−3). Investments in new farm reservoirs for irrigating wheat are currently not profitable (AVW = –0.23 £ m−3). Sensitivity analysis suggests that in the longer term, the expected increase in world wheat prices and the impacts of climate change are likely to make the financial benefits stronger, particularly in the drier catchments further east and on low moisture retentive soils, but competing demands for water would still make extensive wheat irrigation unlikely

Assessing the financial and environmental impacts of precision irrigation in a humid climate

Precision agriculture is increasingly used where in-field spatial variability exists; however, the benefits of its use in humid climates are less apparent. This paper reports on a cost-benefit assessment of precision irrigation with variable rate technique (VRI) versus conventional irrigation, both compared to rainfed production, using a travelling hose-reel irrigator fitted with a boom on onions in eastern England. Selected environmental outcomes including water savings and CO2e emissions are evaluated. The modelled precision irrigation system, which responds to soil variability, generates better environmental outcomes than the conventional system in terms of water savings and reduced CO2e emissions (22.6% and 23.0% lower, respectively). There is also an increase in the ‘added value’ of the irrigation water used (£3.02/m3 versus £2.36/m3). Although precision irrigation leads to significant financial benefits from water and energy savings, these alone do not justify the additional equipment investment costs. However, any changes in yield or quality benefits, equipment costs or greater soil variability than on this site would make investment in precision irrigation more viable

Essential irrigation and the economics of strawberries in a temperate climate

Strawberries are a high value crop in the UK soft fruit sector, with the majority of production grown at field-scale and under protected (polytunnel) conditions. Despite its importance to the rural economy, there is surprisingly little published scientific evidence on the economics of irrigated strawberry production and the value of water in this horticultural sector. A survey of growers, supplemented by secondary data and industry sources, shows considerable variation in key physical and financial performance indicators, both within and between different strawberry production systems, as well as evidence of good practice. Water application depths ranged widely from 800 to over 2000 m3 ha−1 according to grower and crop variety. Irrigation costs typically range between £1.30 and £2.50 m−3 of water applied, highest where storage reservoirs and public water supplies are used. The average value of irrigation water for strawberry net of costs was about £6 m−3, much higher than for field crops such as potatoes. The importance of a reliable water supply to support irrigated strawberry production is highlighted. Climate change and growing pressures on water resources are likely to force a greater interest in irrigation economics in the soft fruit sector, especially in the face of restrictions on summer abstraction and rising competition and charges for using public water supply

Development of a Nodal Method for the Solution of the Neutron Diffusion Equation in General Cylindrical Geometry

The usual strategy for solving the neutron diffusion equation in two or three dimensions by nodal methods is to reduce the multidimensional partial differential equation to a set of ordinary differential equations (ODEs) in the separate spatial coordinates. This reduction is accomplished by “transverse integration” of the equation.1 For example, in three-dimensional Cartesian coordinates, the three-dimensional equation is first integrated over x and y to obtain an ODE in z, then over x and z to obtain an ODE in y, and finally over y and z to obtain an ODE in x. Then the ODEs are solved to obtain onedimensional solutions for the neutron fluxes averaged over the other two dimensions. These solutions are found in regions (“nodes”) small enough for the material properties and cross sections in them to be adequately represented by average values. Because the solution in each node is an exact analytical solution, the nodes can be much larger than the mesh elements used in finite-difference solutions. Then the solutions in the different nodes are coupled by applying interface conditions, ultimately fixing the solutions to the external boundary conditions

A Preliminary Study of the Effect of Shifts in Packing Fraction on k-effective in Pebble-Bed Reactors

A preliminary examination of the effect of pebble packing changes on the reactivity of a pebble-bed reactor (PBR) is performed. As a first step, using the MCNP code, the modeling of a PBR core as a continuous and homogenous region is compared to the modeling as a collection of discrete pebbles of equal average fuel density. It is shown that the two modeling approaches give the same trends inasmuch as changes in keff are concerned. It is thus shown that for the purpose of identifying trends in keff changes, the use of a homogeneous model is sufficient. A homogenous model is then used to assess the effect of pebble packing arrangement changes on the reactivity of a PBR core. It is shown that the changes can be large enough to result in prompt criticality. It is shown that for uranium fueled PBRs, thermal feedback could have the potential to offset the increase in activity, whereas for plutonium fueled systems, thermal feedback may not be sufficient for totally offsetting the packing-increase reactivity insertion and could even exacerbate the initial response. It is thus shown that a full study, including reactor kinetics, thermal feedback, and the dynamics of energy deposition and removal is warranted to fully characterize the potential consequences of packing shifts

An Open-Label, Multicenter, Phase I, Dose Escalation Study with Phase II Expansion Cohort to Determine the Safety, Pharmacokinetics, and Preliminary Antitumor Activity of Intravenous TKM-080301 in Subjects with Advanced Hepatocellular Carcinoma.

Lessons learnedTKM-080301 showed a favorable toxicity profile at the studied dose.TKM-080301 targeting PLK1 through small interfering RNA mechanism did not demonstrate improved overall survival in patients with advanced hepatocellular carcinoma compared with historical control. Preliminary antitumor activity as shown in this early-phase study does not support further evaluation as a single agent.BackgroundPolo-like kinase 1 (PLK1) is overexpressed in hepatocellular carcinoma (HCC). Knockdown of PLK1 expression by PLK1 small interfering RNA (siRNA) in an HCC cell line showed reduced expression in RNA-induced silencing complex and a reduction in cell proliferation.MethodsA 3 + 3 dose escalation plus expansion cohort at the maximum tolerated dose (MTD) was implemented. Patients with HCC, Eastern Cooperative Oncology Group (ECOG) performance status ≤2, and Child-Pugh score A received TKM-080301 as an intravenous infusion once every week for 3 consecutive weeks, repeated every 28 days.ResultsThe study enrolled 43 patients. The starting dose of TKM-080301 was 0.3 mg/kg, and MTD was declared at 0.75 mg/kg. Following the development of grade 4 thrombocytopenia in two subjects on the expansion cohort, the MTD was redefined at 0.6 mg/kg. Four patients did not have any evaluable postbaseline scan. Of the other 39 subjects who had received at least 0.3 mg/kg, 18 subjects (46.2%) had stable disease (SD) by independent RECIST 1.1 criteria. By Choi criteria, eight subjects (23.1%) had a partial response (PR). For 37 assessable subjects, with 2 subjects censored, median progression-free survival (PFS) was 2.04 months. Median survival for the whole study population was 7.5 months.ConclusionTKM-080301 was generally well tolerated. In this early-phase study, antitumor effect for TKM 080301 was limited. Further evaluation as a single agent in large randomized trials is not warranted

Utilization of community pharmacy space to enhance privacy: A qualitative study

© 2015 The Authors. Background: Community pharmacists require access to consumers' information about their medicines and health-related conditions to make informed decisions regarding treatment options. Open communication between consumers and pharmacists is ideal although consumers are only likely to disclose relevant information if they feel that their privacy requirements are being acknowledged and adhered to. Objective: This study sets out to explore community pharmacy privacy practices, experiences and expectations and the utilization of available space to achieve privacy. Methods: Qualitative methods were used, comprising a series of face-to-face interviews with 25 pharmacists and 55 pharmacy customers in Perth, Western Australia, between June and August 2013. Results: The use of private consultation areas for certain services and sensitive discussions was supported by pharmacists and consumers although there was recognition that workflow processes in some pharmacies may need to change to maximize the use of private areas. Pharmacy staff adopted various strategies to overcome privacy obstacles such as taking consumers to a quieter part of the pharmacy, avoiding exposure of sensitive items through packaging, lowering of voices, interacting during pharmacy quiet times and telephoning consumers. Pharmacy staff and consumers regularly had to apply judgement to achieve the required level of privacy. Discussion: Management of privacy can be challenging in the community pharmacy environment, and on-going work in this area is important. As community pharmacy practice is increasingly becoming more involved in advanced medication and disease state management services with unique privacy requirements, pharmacies' layouts and systems to address privacy challenges require a proactive approach

Matrix Formulation of Pebble Circulation in the PEBBED Code

The PEBBED technique provides a foundation for equilibrium fuel-cycle analysis and optimization in pebble-bed cores in which the fuel elements are continuously flowing and, if desired, recirculating. In addition to the modern analysis techniques used in, or being developed for, the code, PEBBED incorporates a novel nuclide-mixing algorithm that allows for sophisticated recirculation patterns using a matrix generated from basic core parameters. Derived from a simple partitioning of the pebble flow, the elements of the recirculation matrix are used to compute the spatially averaged density of each nuclide at the entry plane from the nuclide densities of pebbles emerging from the discharge conus. The order of the recirculation matrix is a function of the flexibility and sophistication of the fuel handling mechanism. This formulation for coupling pebble flow and neutronics enables core design and fuel cycle optimization to be performed by manipulating a few key core parameters. The formulation is amenable to modern optimization techniques

D-cycloserine-augmented one-session treatment of specific phobias in children and adolescents.

BACKGROUND: D-Cycloserine has potential to enhance exposure therapy outcomes. The current study presents a preliminary randomized, placebo-controlled double-blind pilot trial of DCS-augmented one-session treatment (OST) for youth (7-14 years) with specific phobia. A secondary aim of this pilot study was to explore the effects of youth age and within-session fear reduction as potential moderators of DCS outcomes in order to generate hypotheses for a larger trial. It was hypothesized that DCS would be associated with greater improvements than placebo, that children (7-10 years) would have greater benefits than adolescents (11-14 years), and that DCS effects would be stronger for participants with the greater within-session fear reduction during the OST. METHODS: Thirty-five children and adolescents were randomized to either OST combined with DCS (n = 17), or OST combined with placebo (PBO; n = 18) and assessed at 1 week, 1 month, and 3 month following treatment. RESULTS: There were no significant pre- to post-treatment or follow-up benefits of DCS relative to placebo. Secondary analyses of age indicated that relative to PBO, DCS was associated with greater improvements for children (but not adolescents) on measures of severity at 1-month follow-up. Children in the DCS condition also showed significantly greater improvement to 1 month on global functioning relative to other groups. Conversely, adolescents had significant post-treatment benefits in the PBO condition on symptom severity measures relative to DCS, and adolescents in the DCS condition had significantly poorer functioning at 3 months relative to all other groups. Finally, there was a trend for within-session fear reduction to be associated with moderating effects of DCS, whereby greater reduction in fear was associated with greater functioning at one-month follow-up for children who received DCS, relative to PBO. LIMITATIONS: The study sample was small and therefore conclusions are tentative and require replication. CONCLUSIONS: Age and within-session fear reduction may be important moderators of DCS-augmented one-session exposure therapy, which requires testing in a fully powered randomized controlled trial

Fetus in fetu: a case report

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