List Size, Standards and Perfromance in General Practice - A Pilot Study in the South East Thames Region

This is a report of a piolt study carried out among 155 general practitioner trainers in South East Thames region. Similar pilot studies have been carried out among trainers in four other regions on England. Separate reports have been prepared for each of the five regions, together with a summary report comparing the findings among the regions. The pilot studies were funded by the DHSS and carried out by staff of the Health Services Research Unit at the University of Kent at Camterbury

Calcium signalling links MYC to NUAK1

NUAK1 is a member of the AMPK-related family of kinases. Recent evidence suggests that NUAK1 is an important regulator of cell adhesion and migration, cellular and organismal metabolism, and regulation of TAU stability. As such, NUAK1 may play key roles in multiple diseases ranging from neurodegeneration to diabetes and metastatic cancer. Previous work revealed a crucial role for NUAK1 in supporting viability of tumour cells specifically when MYC is overexpressed. This role is surprising, given that NUAK1 is activated by the tumour suppressor LKB1. Here we show that, in tumour cells lacking LKB1, NUAK1 activity is maintained by an alternative pathway involving calcium-dependent activation of PKCα. Calcium/PKCα-dependent activation of NUAK1 supports engagement of the AMPK-TORC1 metabolic checkpoint, thereby protecting tumour cells from MYC-driven cell death, and indeed, MYC selects for this pathway in part via transcriptional regulation of PKCα and ITPR. Our data point to a novel role for calcium in supporting tumour cell viability and clarify the synthetic lethal interaction between NUAK1 and MYC

Hush-a-bye, Ma Baby Missouri Waltz

Hush-a-bye, ma baby, slumbertime is comin’ soon;Rest yo’head upon ma breast while Mammy hums a tune;The sandman is callin’ where shadows are fallin’,While the soft breezes sigh as in days long gone by.‘Way down in Missouri where I heard this melody,When I was a Pickaninny on ma Mammy’s knee;The darkies were hummin,’ their banjos were strummin’ so sweet and low.Strum, strum, strum, strum, strum,Seems I hear those banjos playin’ once again,Hum, hum, hum, hum, hum,That same old plaintive strain. [Instrumental interlude] Hear that mournful melody, it just haunts you the whole day long,And you wander in dreams back to Dixie it seems,When you hear that old time song.Hush-a-bye, ma baby, go to sleep on Mammy’s knee,Journey back to Dixieland in dreams again with me;It seems yo Mammy was there once again,And the darkies were strummin’ that same old refrain.Way down in Missouri where I learned this lullaby,When the stars were blinkin’ and the moon was climbin’ high,And I hear Mammy Cloe, as in days long agoSinging hush-a-bye

Hush-a-bye, ma baby

https://digitalcommons.ithaca.edu/sheetmusic/1049/thumbnail.jp

2W/nm Peak-power All-Fiber Supercontinuum Source and its Application to the Characterization of Periodically Poled Nonlinear Crystals

We demonstrate a uniform high spectral brightness and peak power density all-fiber supercontinuum source. The source consists of a nanosecond Ytterbium fiber laser and an optimal length PCF producing a continuum with a peak power density of 2 W/nm and less than 5 dB of spectral variation between 590 to 1500 nm. The Watt level per nm peak power density enables the use of such sources for the characterization of nonlinear materials. Application of the source is demonstrated with the characterization of several periodically poled crystals.Comment: 8 pages 4 figures v2 includes revisions to the description of the continuum formatio

Single-mode photonic crystal fiber with an effective area of 600 square-micron and low bending loss

A single-mode all-silica photonic crystal fiber with an effective area of 600 square-micron and low bending loss is demonstrated. The fiber is characterized in terms of attenuation, chromatic dispersion and modal properties.Comment: 10 pages including 3 figures. Accepted for Electronics Letter

The Mystery of Two Straight Lines in Bacterial Genome Statistics. Release 2007

In special coordinates (codon position--specific nucleotide frequencies) bacterial genomes form two straight lines in 9-dimensional space: one line for eubacterial genomes, another for archaeal genomes. All the 348 distinct bacterial genomes available in Genbank in April 2007, belong to these lines with high accuracy. The main challenge now is to explain the observed high accuracy. The new phenomenon of complementary symmetry for codon position--specific nucleotide frequencies is observed. The results of analysis of several codon usage models are presented. We demonstrate that the mean--field approximation, which is also known as context--free, or complete independence model, or Segre variety, can serve as a reasonable approximation to the real codon usage. The first two principal components of codon usage correlate strongly with genomic G+C content and the optimal growth temperature respectively. The variation of codon usage along the third component is related to the curvature of the mean-field approximation. First three eigenvalues in codon usage PCA explain 59.1%, 7.8% and 4.7% of variation. The eubacterial and archaeal genomes codon usage is clearly distributed along two third order curves with genomic G+C content as a parameter.Comment: Significantly extended version with new data for all the 348 distinct bacterial genomes available in Genbank in April 200

Human well-being impacts of terrestrial protected areas

© 2013 Pullin et al.; licensee BioMed Central Ltd. Background: Establishing Protected Areas (PAs) is among the most common conservation interventions. Protecting areas from the threats posed by human activity will by definition inhibit some human actions. However, adverse impacts could be balanced by maintaining ecosystem services or introducing new livelihood options. Consequently there is an ongoing debate on whether the net impact of PAs on human well-being at local or regional scales is positive or negative. We report here on a systematic review of evidence for impacts on human well-being arising from the establishment and maintenance of terrestrial PAs. Methods: Following an a priori protocol, systematic searches were conducted for evidence of impacts of PAs post 1992. After article title screening, the review was divided into two separate processes; a qualitative synthesis of explanations and meaning of impact and a review of quantitative evidence of impact. Abstracts and full texts were assessed using inclusion criteria and conceptual models of potential impacts. Relevant studies were critically appraised and data extracted and sorted according to type of impact reported. No quantitative synthesis was possible with the evidence available. Two narrative syntheses were produced and their outputs compared in a metasynthesis. Results: The qualitative evidence review mapped 306 articles and synthesised 34 that were scored as high quality. The quantitative evidence review critically appraised 79 studies and included 14 of low/medium susceptibility to bias. The meta-synthesis reveals that a range of factors can lead to reports of positive and negative impacts of PA establishment, and therefore might enable hypothesis generation regarding cause and effect relationships, but resulting hypotheses cannot be tested with the current available evidence. Conclusions: The evidence base provides a range of possible pathways of impact, both positive and negative, of PAs on human well-being but provides very little support for decision making on how to maximise positive impacts. The nature of the research reported to date forms a diverse and fragmented body of evidence unsuitable for the purpose of informing policy formation on how to achieve win-win outcomes for biodiversity and human well-being. To better assess the impacts of PAs on human well-being we make recommendations for improving research study design and reporting

Entanglement in bipartite generalized coherent states

Entanglement in a class of bipartite generalized coherent states is discussed. It is shown that a positive parameter can be associated with the bipartite generalized coherent states so that the states with equal value for the parameter are of equal entanglement. It is shown that the maximum possible entanglement of 1 bit is attained if the positive parameter equals $\sqrt{2}$. The result that the entanglement is one bit when the relative phase between the composing states is $\pi$ in bipartite coherent states is shown to be true for the class of bipartite generalized coherent states considered.Comment: 10 pages, 4 figures; typos corrected and figures redrawn for better clarit