265 research outputs found
Automated Document Conversion: A Manager\u27s Perspective
Technological advances in our workplaces have made electronic documents pervasive throughout the USAF, DoD, and civilian world. Managers are recognizing the need to establish electronic document management systems to handle these diverse forms of documents. Unfortunately, they have been faced with essentially reinventing the wheel, when it comes to determining which types of paper-based documents are best suited to conversion to an electronic format. There is also a lack of clearly identifiable cost factors associated with automated document conversion (ADC) for managers to use when conducting an economic analysis of a potential imaging application. This thesis addresses the problem of developing a practical solution to identify cost and mission effective ADC applications, and the primary cost factors associated with ADC, both tangible and intangible. While the researcher offers no statistically significant findings, valuable information is presented which helps managers identify ADC applications which will provide the most mission impact for their precious resources. It also provides an understanding of the tangible and intangible benefits of an ADC project, as identified by experts in the document imaging field. Additional lessons learned are related by the experts which provides information valuable to managers considering this technology for solving their own business problems
PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos.
Animal studies have shown that paraoxonase 1 (PON1) genotype can influence susceptibility to the organophosphorus pesticide chlorpyrifos (CPF). However, Monte Carlo analysis suggests that PON1 genotype may not affect CPF-related toxicity at low exposure conditions in humans. The current study sought to determine the influence of PON1 genotype on the activity of blood cholinesterase as well as the effect of CPF exposure on serum PON1 in workers occupationally exposed to CPF. Saliva, blood and urine were collected from agricultural workers (n=120) from Egypt's Menoufia Governorate to determine PON1 genotype, blood cholinesterase activity, serum PON1 activity towards chlorpyrifos-oxon (CPOase) and paraoxon (POase), and urinary levels of the CPF metabolite 3,5,6-trichloro-2-pyridinol (TCPy). The PON1 55 (P≤0.05) but not the PON1 192 genotype had a significant effect on CPOase activity. However, both the PON1 55 (P≤0.05) and PON1 192 (P≤0.001) genotypes had a significant effect on POase activity. Workers had significantly inhibited AChE and BuChE after CPF application; however, neither CPOase activity nor POase activity was associated with ChE depression when adjusted for CPF exposure (as determined by urinary TCPy levels) and stratified by PON1 genotype. CPOase and POase activity were also generally unaffected by CPF exposure although there were alterations in activity within specific genotype groups. Together, these results suggest that workers retained the capacity to detoxify chlorpyrifos-oxon under the exposure conditions experienced by this study population regardless of PON1 genotype and activity and that effects of CPF exposure on PON1 activity are minimal
Structure and structure relaxation
A discrete--dynamics model, which is specified solely in terms of the
system's equilibrium structure, is defined for the density correlators of a
simple fluid. This model yields results for the evolution of glassy dynamics
which are identical with the ones obtained from the mode-coupling theory for
ideal liquid--glass transitions. The decay of density fluctuations outside the
transient regime is shown to be given by a superposition of Debye processes.
The concept of structural relaxation is given a precise meaning. It is proven
that the long-time part of the mode-coupling-theory solutions is structural
relaxation, while the transient motion merely determines an overall time scale
for the glassy dynamics
Valley degeneracy in biaxially strained aluminum arsenide quantum wells
This paper details a complete formalism for calculating electron subband
energy and degeneracy in strained multi-valley quantum wells grown along any
orientation with explicit results for the AlAs quantum well case. A
standardized rotation matrix is defined to transform from the conventional-
cubic-cell basis to the quantum-well-transport basis whereby effective mass
tensors, valley vectors, strain matrices, anisotropic strain ratios, and
scattering vectors are all defined in their respective bases. The specific
cases of (001)-, (110)-, and (111)-oriented aluminum arsenide (AlAs) quantum
wells are examined, as is the unconventional (411) facet, which is of
particular importance in AlAs literature. Calculations of electron confinement
and strain in the (001), (110), and (411) facets determine the critical well
width for crossover from double- to single-valley degeneracy in each system.
The notation is generalized to include miscut angles, and can be adapted to
other multi-valley systems. To help classify anisotropic inter-valley
scattering events, a new primitive unit cell is defined in momentum space which
allows one to distinguish purely in-plane inter-valley scattering events from
those that requires an out-of-plane momentum scattering component.Comment: 17 pages, 4 figures, 2 table
Sterile Neutrinos, Coherent Scattering and Oscillometry Measurements with Low-temperature Bolometers
Coherent neutrino-nucleon scattering offers a unique approach in the search
for physics beyond the Standard Model. When used in conjunction with
mono-energetic neutrino sources, the technique can be sensitive to the
existence of light sterile neutrinos. The ability to utilize such reactions has
been limited in the past due to the extremely low energy threshold (10-50 eV)
needed for detection. In this paper, we discuss an optimization of cryogenic
solid state bolometers that enables reaching extremely low kinetic energy
thresholds. We investigate the sensitivity of an array of such detectors to
neutrino oscillations to sterile states. A recent analysis of available reactor
data appears to favor the existence of such such a sterile neutrino with a mass
splitting of eV and mixing strength of
at 95% C.L. An array of such
low-threshold detectors would be able to make a definitive statement as to the
validity of the interpretation.Comment: 14 pages, 10 figures. Version 2: Temperature dependence on alpha
fixed from earlier versio
Multiple-scattering effects on incoherent neutron scattering in glasses and viscous liquids
Incoherent neutron scattering experiments are simulated for simple dynamic
models: a glass (with a smooth distribution of harmonic vibrations) and a
viscous liquid (described by schematic mode-coupling equations). In most
situations multiple scattering has little influence upon spectral
distributions, but it completely distorts the wavenumber-dependent amplitudes.
This explains an anomaly observed in recent experiments
Molecular mode-coupling theory applied to a liquid of diatomic molecules
We study the molecular mode coupling theory for a liquid of diatomic
molecules. The equations for the critical tensorial nonergodicity parameters
and the critical amplitudes of the - relaxation
are solved up to a cut off = 2 without any
further approximations.
Here are indices of spherical harmonics. Contrary to previous studies,
where additional approximations were applied, we find in agreement with
simulations, that all molecular degrees of freedom vitrify at a single
temperature . The theoretical results for the non ergodicity parameters
and the critical amplitudes are compared with those from simulations. The
qualitative agreement is good for all molecular degrees of freedom. To study
the influence of the cut off on the non ergodicity parameter, we also calculate
the non ergodicity parameters for an upper cut off . In addition we
also propose a new method for the calculation of the critical nonergodicity
parameterComment: 27 pages, 17 figure
Energy landscape - a key concept for the dynamics of glasses and liquids
There is a growing belief that the mode coupling theory is the proper
microscopic theory for the dynamics of the undercooled liquid above a critical
temperature T_c. In addition, there is some evidence that the system leaves the
saddlepoints of the energy landscape to settle in the valleys at this critical
temperature. Finally, there is a microscopic theory for the entropy at the
calorimetric glass transition T_g by Mezard and Parisi, which allows to
calculate the Kauzmann temperature from the atomic pair potentials.
The dynamics of the frozen glass phase is at present limited to
phenomenological models. In the spirit of the energy landscape concept, one
considers an ensemble of independent asymmetric double-well potentials with a
wide distribution of barrier heights and asymmetries (ADWP or Gilroy-Phillips
model). The model gives an excellent description of the relaxation of glasses
up to about T_g/4. Above this temperature, the interaction between different
relaxation centers begins to play a role. One can show that the interaction
reduces the number of relaxation centers needed to bring the shear modulus down
to zero by a factor of three.Comment: Contribution to the III Workshop on Nonequilibrium Phenomena in
Supercooled Fluids, Glasses and Amorphous Materials, 22-27 September 2002,
Pisa; 14 pages, 3 figures; Version 3 takes criticque at Pisa into account;
final version 4 will be published in J.Phys.: Condens.Matte
Mapping Dynamic Histone Acetylation Patterns to Gene Expression in Nanog-depleted Murine Embryonic Stem Cells
Embryonic stem cells (ESC) have the potential to self-renew indefinitely and
to differentiate into any of the three germ layers. The molecular mechanisms
for self-renewal, maintenance of pluripotency and lineage specification are
poorly understood, but recent results point to a key role for epigenetic
mechanisms. In this study, we focus on quantifying the impact of histone 3
acetylation (H3K9,14ac) on gene expression in murine embryonic stem cells. We
analyze genome-wide histone acetylation patterns and gene expression profiles
measured over the first five days of cell differentiation triggered by
silencing Nanog, a key transcription factor in ESC regulation. We explore the
temporal and spatial dynamics of histone acetylation data and its correlation
with gene expression using supervised and unsupervised statistical models. On a
genome-wide scale, changes in acetylation are significantly correlated to
changes in mRNA expression and, surprisingly, this coherence increases over
time. We quantify the predictive power of histone acetylation for gene
expression changes in a balanced cross-validation procedure. In an in-depth
study we focus on genes central to the regulatory network of Mouse ESC,
including those identified in a recent genome-wide RNAi screen and in the
PluriNet, a computationally derived stem cell signature. We find that compared
to the rest of the genome, ESC-specific genes show significantly more
acetylation signal and a much stronger decrease in acetylation over time, which
is often not reflected in an concordant expression change. These results shed
light on the complexity of the relationship between histone acetylation and
gene expression and are a step forward to dissect the multilayer regulatory
mechanisms that determine stem cell fate.Comment: accepted at PLoS Computational Biolog
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