The Upper Guinea Coast in Global Perspective

For centuries, Africa’s Upper Guinea Coast region has been the site of regional and global interactions, with societies from different parts of the African continent and beyond engaging in economic trade, cultural exchange, and various forms of conflict. This book provides a wide-ranging look at how such encounters have continued into the present day, identifying the disruptions and continuities in religion, language, economics, and various other social phenomena that have resulted. These accounts show a region that, while still grappling with the legacies of colonialism and the slave trade, is both shaped by and an important actor within ever-denser global networks, exhibiting consistent transformation and creative adaptation

Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.

Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis of some ALCL subgroups is still unsatisfactory, and already in second line effective treatment options are lacking. To identify genes defining ALCL cell state and dependencies, we here characterize super-enhancer regions by genome-wide H3K27ac ChIP-seq. In addition to known ALCL key regulators, the AP-1-member BATF3 and IL-2 receptor (IL2R)-components are among the top hits. Specific and high-level IL2R expression in ALCL correlates with BATF3 expression. Confirming a regulatory link, IL-2R-expression decreases following BATF3 knockout, and BATF3 is recruited to IL2R regulatory regions. Functionally, IL-2, IL-15 and Neo-2/15, a hyper-stable IL-2/IL-15 mimic, accelerate ALCL growth and activate STAT1, STAT5 and ERK1/2. In line, strong IL-2Rα-expression in ALCL patients is linked to more aggressive clinical presentation. Finally, an IL-2Rα-targeting antibody-drug conjugate efficiently kills ALCL cells in vitro and in vivo. Our results highlight the importance of the BATF3/IL-2R-module for ALCL biology and identify IL-2Rα-targeting as a promising treatment strategy for ALCL

The Upper Guinea Coast in Global Perspective

For centuries, Africa’s Upper Guinea Coast region has been the site of regional and global interactions, with societies from different parts of the African continent and beyond engaging in economic trade, cultural exchange, and various forms of conflict. This book provides a wide-ranging look at how such encounters have continued into the present day, identifying the disruptions and continuities in religion, language, economics, and various other social phenomena that have resulted. These accounts show a region that, while still grappling with the legacies of colonialism and the slave trade, is both shaped by and an important actor within ever-denser global networks, exhibiting consistent transformation and creative adaptation

The creolization reader: studies in mixed identities and cultures

This book is not available via ORA