Internal Friction and Vulnerability of Mixed Alkali Glasses

Based on a hopping model we show how the mixed alkali effect in glasses can be understood if only a small fraction c_V ofthe available sites for the mobile ions is vacant. In particular, we reproduce the peculiar behavior of the internal friction and the steep fall (''vulnerability'') of the mobility of the majority ion upon small replacements by the minority ion. The single and mixed alkali internal friction peaks are caused by ion-vacancy and ion-ion exchange processes. If c_V is small, they can become comparable in height even at small mixing ratios. The large vulnerability is explained by a trapping of vacancies induced by the minority ions. Reasonable choices of model parameters yield typical behaviors found in experiments.Comment: 4 pages, 4 figure

VESTIGE: Adjuvant Immunotherapy in Patients With Resected Esophageal, Gastroesophageal Junction and Gastric Cancer Following Preoperative Chemotherapy With High Risk for Recurrence (N+ and/or R1): An Open Label Randomized Controlled Phase-2-Study.

Background: Perioperative chemotherapy plus surgery is one recommended standard treatment for patients with resectable gastric and esophageal cancer. Even with a multimodality treatment more than half of patients will relapse following surgical resection. Patients who have a poor response to neoadjuvant chemotherapy and have an incomplete (R1) resection or have metastatic lymph nodes in the resection specimen (N+) are especially at risk of recurrence. Current clinical practice is to continue with the same chemotherapy in the adjuvant setting as before surgery. In the phase II randomized EORTC VESTIGE trial (NCT03443856), patients with high risk resected gastric or esophageal adenocarcinoma will be randomized to either adjuvant chemotherapy (as before surgery) or to immunotherapy with nivolumab and low dose ipilimumab (nivolumab 3 mg/kg IV Q2W plus Ipilimumab 1 mg/kg IV Q6W for 1 year). The primary endpoint of the study is disease free survival, with secondary endpoints of overall survival, safety and toxicity, and quality of life. This is an open label randomized controlled multi-center phase-2 superiority trial. Patients will be randomized in a 1:1 ratio to study arms. The trial will recruit 240 patients; recruitment commenced July 2019 and is anticipated to take 30 months. Detailed inclusion/exclusion criteria, toxicity management guidelines, and statistical plans for EORTC VESTIGE are described in the manuscript. Clinical Trial Registration: The trial is registered with www.ClinicalTrials.gov, identifier: NCT03443856

Was wissen Gedächtnistrainer über ihre „Schüler“?: ein empirischer Beitrag zur Gerontagogik

In the context of research on life-long learning, the present study focuses on the question if active memory trainers have a realistic estimation of the cognitive capacities of their trainees. A second question targets the influence of pre-post-tests as an integral element of memory trainings. The study is based upon a survey among the members of a German-wide operating memory trainer organisation, the "Bundesverband Gedächtnistraining e.V." 183 persons participated in the survey. Results show that the trainers have a relatively accurate and differentiated view about the general cognitive capacity of their trainees. Although pre-post-tests are rarely used, data reveal that they enhance the correlation between the estimated possible gain and the estimated improvement after the training. In general, the results of the present study support that pre-post-tests should be applied as an integral element of cognitive trainings as they make them more effective by providing the trainers with more accurate information regarding their trainees

Electromagnetic proton-neutron knockout off 16O: new achievements in theory

Results for the cross sections of the exclusive 16O(e,e'pn)14N and 16O(gamma,pn)14N knockout reactions are presented and discussed in different kinematics. In comparison with earlier work, a complete treatment of the center-of-mass (CM) effects in the nuclear one-body current is considered in connection with the problem of the lack of orthogonality between initial bound and final scattering states. The effects due to CM and orthogonalization are investigated in combination with different treatments of correlations in the two-nucleon overlap function and for different parametrizations of the two-body currents. The CM effects lead in super-parallel kinematics to a dramatic increase of the 16O(e,e'pn) cross section to the 1_2^+ excited state (3.95 MeV) of 14N. In all the situations considered the results are very sensitive to the treatment of correlations. A crucial role is played by tensor correlations, but also the contribution of long-range correlations is important.Comment: 13 pages, 10 figure

NN final-state interaction in two-nucleon knockout from 16O^{16}O

The influence of the mutual interaction between the two outgoing nucleons (NN-FSI) in electro- and photoinduced two-nucleon knockout from $^{16}O$ has been investigated perturbatively. It turns out that the effect of NN-FSI depends on the kinematics and on the type of reaction considered. The effect is generally larger in pp- than in pn-knockout and in electron induced than in photoinduced reactions. In superparallel kinematics NN-FSI leads in the $(e,e'pp)$ channel to a strong increase of the cross section, that is mainly due to a strong enhancement of the $\Delta$-current contribution. In pn-emission, however, this effect is partially cancelled by a destructive interference with the seagull current. For photoreactions NN-FSI is considerably reduced in superparallel kinematics and can be practically negligible in specific kinematics.Comment: 16 pages, 9 figure

Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1

When a growing cell expands, lipids and proteins must be delivered to its periphery. Although this phenomenon has been observed for decades, it remains unknown how the secretory pathway responds to growth signaling. We demonstrate that control of Golgi phosphatidylinositol-4-phosphate (PI(4)P) is required for growth-dependent secretion. The phosphoinositide phosphatase SAC1 accumulates at the Golgi in quiescent cells and down-regulates anterograde trafficking by depleting Golgi PI(4)P. Golgi localization requires oligomerization of SAC1 and recruitment of the coat protein (COP) II complex. When quiescent cells are stimulated by mitogens, SAC1 rapidly shuttles back to the endoplasmic reticulum (ER), thus releasing the brake on Golgi secretion. The p38 mitogen-activated kinase (MAPK) pathway induces dissociation of SAC1 oligomers after mitogen stimulation, which triggers COP-I–mediated retrieval of SAC1 to the ER. Inhibition of p38 MAPK abolishes growth factor–induced Golgi-to-ER shuttling of SAC1 and slows secretion. These results suggest direct roles for p38 MAPK and SAC1 in transmitting growth signals to the secretory machinery

Nucleon-Nucleon Correlations and Two-Nucleon Currents in Exclusive (e,e′NNe,e'NN) Reactions

The contributions of short-range nucleon-nucleon (NN) correlations, various meson exchange current (MEC) terms and the influence of $\Delta$ isobar excitations (isobaric currents, IC) on exclusive two-nucleon knockout reactions induced by electron scattering are investigated. The nuclear structure functions are evaluated for nuclear matter. Realistic NN interactions derived in the framework of One-Boson-Exchange model are employed to evaluate the effects of correlations and MEC in a consistent way. The correlations correlations are determined by solving the Bethe-Goldstone equation. This yields significant contributions to the structure functions W_L and W_T of the (e,e'pn) and (e,e'pp) reactions. These contributions compete with MEC corrections originating from the $\pi$ and $\rho$ exchange terms of the same interaction. Special attention is paid to the so-called 'super parallel' kinematics at momentum transfers which can be measured e.g. at MAMI in Mainz.Comment: 14 pages, 8 figures include

A model for two-proton emission induced by electron scattering

A model to study two-proton emission processes induced by electron scattering is developed. The process is induced by one-body electromagnetic operators acting together with short-range correlations, and by two-body $\Delta$ currents. The model includes all the diagrams containing a single correlation function. A test of the sensitivity of the model to the various theoretical inputs is done. An investigation of the relevance of the $\Delta$ currents is done by changing the final state angular momentum, excitation energy and momentum transfer. The sensitivity of the cross section to the details of the correlation function is studied by using realistic and schematic correlations. Results for $^{12}$C, $^{16}$O and $^{40}$Ca nuclei are presented.Comment: 30 pages, 18 figures, 3 table

Detection of adulterations with different grains in wheat products based on the hyperspectral image technique: The specific cases of flour and bread

[EN] The objective of this study was to test the capability of a SW-NIR hyperspectral image technique to detect adulterations in wheat flour and bread with cheap grains, such us sorghum, oats and corn, and to compare the hyperspectral information with the physicochemical alterations in the properties of products. Wheat flour was adulterated at four different degrees (2.5, 5, 7.5 and 10%) with sorghum, oat and corn flours. Flours were prepared and used to make bread. Flours and breads were characterized according to several physicochemical parameters (pasting properties, water activity, mass loss during the baking process and texture profile analysis). Crumbs were extracted from breads and conditioned. Hyperspectral image captures were taken of both flours and conditioned crumbs. The data analysis was based on multivariate statistical process control method (MSPC), where the differentiation of adulterated samples was observed in all cases for both flours and crumbs. Finally, in order to relate the image analysis results and the adulterated sample properties, a correlation significance map was created between the physicochemical properties of samples and the multivariate statistical parameters. The SW-NIR image technique was capable of detecting adulterations in each case and high correlation significances were observed (alpha = 0.01) between wavelengths from specific spectra zones and the physicochemical properties of samples.Verdú Amat, S.; Vásquez, F.; Grau Meló, R.; Ivorra Martínez, E.; Sánchez Salmerón, AJ.; Barat Baviera, JM. (2016). Detection of adulterations with different grains in wheat products based on the hyperspectral image technique: The specific cases of flour and bread. Food Control. 62:373-380. doi:10.1016/j.foodcont.2015.11.002S3733806

Leveraging large language models for decision support in personalized oncology

IMPORTANCE: Clinical interpretation of complex biomarkers for precision oncology currently requires manual investigations of previous studies and databases. Conversational large language models (LLMs) might be beneficial as automated tools for assisting clinical decision-making. OBJECTIVE: To assess performance and define their role using 4 recent LLMs as support tools for precision oncology. DESIGN, SETTING, AND PARTICIPANTS: This diagnostic study examined 10 fictional cases of patients with advanced cancer with genetic alterations. Each case was submitted to 4 different LLMs (ChatGPT, Galactica, Perplexity, and BioMedLM) and 1 expert physician to identify personalized treatment options in 2023. Treatment options were masked and presented to a molecular tumor board (MTB), whose members rated the likelihood of a treatment option coming from an LLM on a scale from 0 to 10 (0, extremely unlikely; 10, extremely likely) and decided whether the treatment option was clinically useful. MAIN OUTCOMES AND MEASURES: Number of treatment options, precision, recall, F1 score of LLMs compared with human experts, recognizability, and usefulness of recommendations. RESULTS: For 10 fictional cancer patients (4 with lung cancer, 6 with other; median [IQR] 3.5 [3.0-4.8] molecular alterations per patient), a median (IQR) number of 4.0 (4.0-4.0) compared with 3.0 (3.0-5.0), 7.5 (4.3-9.8), 11.5 (7.8-13.0), and 13.0 (11.3-21.5) treatment options each was identified by the human expert and 4 LLMs, respectively. When considering the expert as a criterion standard, LLM-proposed treatment options reached F1 scores of 0.04, 0.17, 0.14, and 0.19 across all patients combined. Combining treatment options from different LLMs allowed a precision of 0.29 and a recall of 0.29 for an F1 score of 0.29. LLM-generated treatment options were recognized as AI-generated with a median (IQR) 7.5 (5.3-9.0) points in contrast to 2.0 (1.0-3.0) points for manually annotated cases. A crucial reason for identifying AI-generated treatment options was insufficient accompanying evidence. For each patient, at least 1 LLM generated a treatment option that was considered helpful by MTB members. Two unique useful treatment options (including 1 unique treatment strategy) were identified only by LLM. CONCLUSIONS AND RELEVANCE: In this diagnostic study, treatment options of LLMs in precision oncology did not reach the quality and credibility of human experts; however, they generated helpful ideas that might have complemented established procedures. Considering technological progress, LLMs could play an increasingly important role in assisting with screening and selecting relevant biomedical literature to support evidence-based, personalized treatment decisions