Identifying the Stream Depletion Paradox by Monitoring a Stream’s Response to Aquifer Pumping from Neighboring Wells

Current groundwater models utilize a constant head (Dirichlet) boundary condition which assumes stream stage is fixed and does not experience any drawdown in the event of pumping from an interconnected aquifer despite the presence of stream depletion. Therefore, constant head boundary implies that streams and lakes in a groundwater model behave as an infinite supply of water when aquifer pumping occurs. This study aimed to determine if a stream located in the California Central Coast experiences drawdown and depletion when pumping occurs within an aquifer-stream system. This was achieved by measuring stream stage, aquifer water levels, stream discharge, and the hydraulic conductivity of the subject streambed. Passively collected stream stage and aquifer water level data, actively collected stream discharge data, and in-situ streambed hydraulic conductivity measurements were taken from August 2022 to August 2023 and analyzed using time series analyses and hydraulic conductivity calculation methods. This study confirmed that stream depletion occurred during aquifer pumping and, at low discharge rates, stream stage exhibits observable drawdown in response to aquifer pumping which contradicts the constant head boundary assumption and confirms the existence of the stream depletion paradox in the subject aquifer-stream system. The streambed hydraulic conductivity was found to be relatively high and contained highly conductive gravels and coarse sands implying that the streambed has relatively high storage capacity in the subject stream. This research, subsequent data collection, and improvements to groundwater modeling will allow water managers and planners to sustainably manage local water resources which will be relied upon for generations to come

Business Model Design and Implementation for eServices

Electronic Commerce (eCommerce) is becoming widely understood in the business-to-consumer market due to earlier market awareness and success stories like amazon.com. New challenges lie ahead to extend eCommerce business models. One area is the extension of simple eCommerce shop solutions to offer more integrated eBusiness solutions and include eServices (Plummer and Smith, 2000). While lacking required capabilities within one company, networks and alliances are becoming an attractive means to achieve that (Chisholm, 1998). A prerequisite to reap the potential benefits is to define an adequate business model that enables decision makers to decide upon these new opportunities. This paper proposes an initial framework for business models. It applies it to the area of eServices in eBusiness. It aims to provide both business executives and researchers with a means to facilitate the definition of new business models and to reduce uncertainty in eBusiness. Further research should focus on refining the framework and on providing design recommendations for business models. This will be achieved by focusing on in-depth case studies on the design and implementation of eServices

Enhancing ERP-Architectures for Business Networking - Case of Deutsche Telekom AG

Many organizations have ERP systems in place and are confronted with initiatives from their functional de- partments, consultants or software vendors that aim at im- plementing solutions for Business Networking. This con- cept includes the design and management of IT-enabled relationships between internal and external business part- ners. It provides a holistic perspective on strategies, such as electronic commerce, supply chain management, and customer relationship management. Since a new array of applications to address these inter-business relationships is swiftly implemented, architectural considerations are often left out. Reasons for this include time pressure, a lack of experience, methods, and concepts. Consequently, existing ERP-centric architectures are not modified or have to be modified after the fact. Using a case example from Deutsche Telekom, this article presents a possible proactive solution for a definition of a future application architecture as well as procedures to achieve a Business Networking architecture that meets business requirements

Frameworks and models to identify and increase the success potential of e-services

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Fish allergy management: from component-resolved diagnosis to unmet diagnostic needs

Purpose of review Fish is a common elicitor of IgE-mediated food allergy. Fish includes a large variety of foods, in terms of species and food processing, with marked distinction in local diets around the globe. Fish-allergic patients present with phenotypic diversity and major differences in levels of clinical cross-reactivity, features that pose an important challenge for the clinical diagnosis and management. Recent findings Parvalbumin is the major fish allergen. However, a single molecule is not sufficient but several homologs, allergens different from parvalbumin and allergen extracts, are needed for IgE-based diagnosis. Summary Parvalbumin-specific IgE are markers for clinical cross-reactions. Added value is provided by IgE typing to parvalbumin homologs from distantly related fish. IgE cosensitization profiles (parvalbumin, enolase, aldolase) are referred as severity markers. The allergen panel seems to be not yet complete why fish extracts still play a crucial role inserum IgE analysis. Further clinical validation of a multiplex approach in molecular fish allergy diagnosis is needed for striving to avoid unnecessary food restrictions and in a further sense, improved patient care.Ministry of Research, Luxembourg (JK, AK), the PRIDE program grant (PRIDE/11012546/NEXTIMMUNE) ;Fonds National de la Recherche (FNR), Luxembourg (JK, AK) and the Personalized Medicine Consortium Luxembourg (JK, AK). This work received national funds through FCT - Foundation for Science and Technology through project UID/Multi/04326/2019. FCT PhD grant SFRH/BD/136319/2018.info:eu-repo/semantics/publishedVersio

Impaired Growth and Force Production in Skeletal Muscles of Young Partially Pancreatectomized Rats: A Model of Adolescent Type 1 Diabetic Myopathy?

This present study investigated the temporal effects of type 1 diabetes mellitus (T1DM) on adolescent skeletal muscle growth, morphology and contractile properties using a 90% partial pancreatecomy (Px) model of the disease. Four week-old male Sprague-Dawley rats were randomly assigned to Px (n = 25) or Sham (n = 24) surgery groups and euthanized at 4 or 8 weeks following an in situ assessment of muscle force production. Compared to Shams, Px were hyperglycemic (>15 mM) and displayed attenuated body mass gains by days 2 and 4, respectively (both P<0.05). Absolute maximal force production of the gastrocnemius plantaris soleus complex (GPS) was 30% and 50% lower in Px vs. Shams at 4 and 8 weeks, respectively (P<0.01). GP mass was 35% lower in Px vs Shams at 4 weeks (1.24±0.06 g vs. 1.93±0.03 g, P<0.05) and 45% lower at 8 weeks (1.57±0.12 vs. 2.80±0.06, P<0.05). GP fiber area was 15–20% lower in Px vs. Shams at 4 weeks in all fiber types. At 8 weeks, GP type I and II fiber areas were ∼25% and 40% less, respectively, in Px vs. Shams (group by fiber type interactions, P<0.05). Phosphorylation states of 4E-BP1 and S6K1 following leucine gavage increased 2.0- and 3.5-fold, respectively, in Shams but not in Px. Px rats also had impaired rates of muscle protein synthesis in the basal state and in response to gavage. Taken together, these data indicate that exposure of growing skeletal muscle to uncontrolled T1DM significantly impairs muscle growth and function largely as a result of impaired protein synthesis in type II fibers

Manufacturing and Supply Chain Flexibility: Building an Integrative Conceptual Model Through Systematic Literature Review and Bibliometric Analysis

The purpose of this study is twofold: first, to establish the current themes on the topic of manufacturing and supply chain flexibility (MSCF), assess their level of maturity in relation to each other, identify the emerging ones and reflect on how they can inform each other, and second, to develop a conceptual model of MSCF that links different themes connect and highlight future research opportunities. The study builds on a sample of 222 articles published from 1996 to 2018 in international, peer-reviewed journals. The analysis of the sample involves two complementary approaches: the co-word technique to identify the thematic clusters as well as their relative standing and a critical reflection on the papers to explain the intellectual content of these thematic clusters. The results of the co-word analysis show that MSCF is a dynamic topic with a rich and complex structure that comprises five thematic clusters. The value chain, capability and volatility clusters showed research topics that were taking a central role in the discussion on MSCF but were not mature yet. The SC purchasing practices and SC planning clusters involved work that was more focused and could be considered more mature. These clusters were then integrated in a framework that built on the competence–capability perspective and identified the major structural and infrastructural elements of MSCF as well as its antecedents and consequences. This paper proposes an integrative framework helping managers keep track the various decisions they need to make to increase flexibility from the viewpoint of the entire value chain

Der Wirtschaftsverkehr zwischen der Bundesrepublik Deutschland und der DDR unter besonderer Beruecksichtigung der steuerlichen Behandlung

Available from Bibliothek des Instituts fuer Weltwirtschaft, ZBW, Duesternbrook Weg 120, D-24105 Kiel Mb 492 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman