1,531 research outputs found
Π ΠΎΠ·ΡΠΎΠ±ΠΊΠ° ΠΌΠΎΠ±ΡΠ»ΡΠ½ΠΎΡ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΡΡ ΡΠ΅ΠΌΠΎΠ½ΡΡ Π½ΠΈΠ·ΡΠΊΠΎΠ²ΡΠ³Π»Π΅ΡΠ΅Π²ΠΈΡ ΡΡΠ°Π»ΡΠ½ΠΈΡ ΡΡΡΠ± Π½ΠΈΠ·ΡΠΊΠΎΠ³ΠΎ ΡΠ° Π²ΠΈΡΠΎΠΊΠΎΠ³ΠΎ ΡΠΈΡΠΊΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΠ°ΠΉΠΊΠΈ Π½ΠΈΠ·ΡΠΊΠΎΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ½ΠΈΠΌΠΈ ΠΏΡΠΈΠΏΠΎΡΠΌΠΈ
Π ΠΎΠ·ΡΠΎΠ±Π»Π΅Π½ΠΎ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΡΡ Π±Π΅Π·Π²ΠΎΠ³Π½Π΅Π²ΠΎΠ³ΠΎ ΡΠ΅ΠΌΠΎΠ½ΡΡ Π΄Π΅ΡΠ΅ΠΊΡΡΠ² ΠΊΠΎΠ½ΡΡΡΡΠΊΡΡΠΉ Π· Π½ΠΈΠ·ΡΠΊΠΎΠ²ΡΠ³Π»Π΅ΡΠ΅Π²ΠΈΡ
ΡΡΠ°Π»Π΅ΠΉ ΡΠ»ΡΡ
ΠΎΠΌ ΠΏΠ°ΠΉΠΊΠΈ Π½ΠΈΠ·ΡΠΊΠΎΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ½ΠΈΠΌΠΈ ΠΏΡΠΈΠΏΠΎΡΠΌΠΈ. Π ΠΎΠ·ΡΠΎΠ±Π»Π΅Π½ΠΎ ΡΠ° Π·Π°ΡΠ²Π»Π΅Π½ΠΎ Π½ΠΎΠ²ΠΈΠΉ ΡΠΊΠ»Π°Π΄ Π»Π΅Π³ΠΊΠΎΠΏΠ»Π°Π²ΠΊΠΎΠ³ΠΎ ΠΏΡΠΈΠΏΠΎΡ Π½Π° Π±Π°Π·Ρ ΠΎΠ»ΠΎΠ²Π° Π· Π΄ΠΎΠΌΡΡΠΊΠ°ΠΌΠΈ ΠΌΡΠ΄Ρ ΡΠ° Π²ΡΡΠΌΡΡΡ. ΠΡΠΈΠΏΡΠΉ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎ ΠΏΠΎΡΠ΄Π½ΡΡ Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΡ ΡΡΠ΄ΠΊΠΎΠΏΠ»ΠΈΠ½Π½ΠΎΡΡΡ, ΠΊΠΎΡΠΎΠ·ΡΠΉΠ½ΠΎΡ ΡΡΡΠΉΠΊΠΎΡΡΡ, ΠΌΡΡΠ½ΠΎΡΡΡ ΡΠ° Π°Π΄Π³Π΅Π·ΡΠΉΠ½ΠΎΡ ΠΌΡΡΠ½ΠΎΡΡΡ. Π’Π΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΡΡ ΠΏΠ°ΠΉΠΊΠΈ ΡΡΠ°Π»Π΅ΠΉ Π½ΠΈΠ·ΡΠΊΠΎΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ½ΠΈΠΌΠΈ ΠΏΡΠΈΠΏΠΎΡΠΌΠΈ ΡΠ· Π·Π°ΡΡΠΎΡΡΠ²Π°Π½Π½ΡΠΌ Π²ΠΈΡΠΎΠΊΠΎΡΠ°ΡΡΠΎΡΠ½ΠΎΠ³ΠΎ Π³Π΅Π½Π΅ΡΠ°ΡΠΎΡΠ° Π΅Π»Π΅ΠΊΡΡΠΈΡΠ½ΠΎΠ³ΠΎ ΡΡΡΡΠΌΡ Π΄ΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Π΄ΠΎ ΡΡΠ°Π½Ρ ΠΏΡΠ°ΠΊΡΠΈΡΠ½ΠΎΠ³ΠΎ Π·Π°ΡΡΠΎΡΡΠ²Π°Π½Π½Ρ.Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π° ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡ Π±Π΅Π·ΠΎΠ³Π½Π΅Π²ΠΎΠ³ΠΎ ΡΠ΅ΠΌΠΎΠ½ΡΠ° Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ² ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ ΠΈΠ· Π½ΠΈΠ·ΠΊΠΎΡΠ³Π»Π΅ΡΠΎΠ΄ΠΈΡΡΡΡ
ΡΡΠ°Π»Π΅ΠΉ ΠΏΡΡΠ΅ΠΌ ΠΏΠ°ΠΉΠΊΠΈ Π½ΠΈΠ·ΠΊΠΎΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ½ΡΠΌΠΈ ΠΏΡΠΈΠΏΠΎΡΠΌΠΈ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΠΈ Π·Π°ΡΠ²Π»Π΅Π½ Π½ΠΎΠ²ΡΠΉ ΡΠΎΡΡΠ°Π² Π»Π΅Π³ΠΊΠΎΠΏΠ»Π°Π²ΠΊΠΎΠ³ΠΎ ΠΏΡΠΈΠΏΠΎΡ Π½Π° Π±Π°Π·Π΅ ΠΎΠ»ΠΎΠ²Π°, Ρ Π΄ΠΎΠ±Π°Π²ΠΊΠ°ΠΌΠΈ ΠΌΠ΅Π΄ΠΈ ΠΈ Π²ΠΈΡΠΌΡΡΠ°. ΠΡΠΈΠΏΠΎΠΉ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎ ΠΎΠ±ΡΠ΅Π΄ΠΈΠ½ΡΠ΅Ρ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΆΠΈΠ΄ΠΊΠΎΡΠ΅ΠΊΡΡΠ΅ΡΡΠΈ, ΠΊΠΎΡΡΠΎΠ·ΠΈΠΎΠ½Π½ΠΎΠΉ ΡΡΠΎΠΉ ΠΊΠΎΡΡΠΈ, ΠΏΡΠΎΡΠ½ΠΎΡΡΠΈ ΠΈ Π°Π΄Π³Π΅Π·ΠΈΠΎΠ½Π½ΠΎΠΉ ΠΏΡΠΎΡΠ½ΠΎΡΡΠΈ. Π’Π΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΏΠ°ΠΉΠΊΠΈ ΡΡΠ°Π»Π΅ΠΉ Π½ΠΈΠ·ΠΊΠΎΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ½ΡΠΌΠΈ ΠΏΡΠΈΠΏΠΎΡΠΌΠΈ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ Π²ΡΡΠΎΠΊΠΎΡΠ°ΡΡΠΎΡΠ½ΠΎΠ³ΠΎ Π³Π΅Π½Π΅ΡΠ°ΡΠΎΡΠ° ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΠΊΠ° Π΄ΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Π΄ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ.The technology of out fire defects repair in low carbon steel constructions by soldering with low- temperature solders is developed. The new fusible tin rich solder composition containing copper and bismuth additives is developed and declared. The solder has optimum properties of liquid stream, corrosion resistance, durability and adhesion strength. The low carbon steel soldering technology with application of high-frequency electric current generator is carried to practical application
Entanglement in the quantum Ising model
We study the asymptotic scaling of the entanglement of a block of spins for
the ground state of the one-dimensional quantum Ising model with transverse
field. When the field is sufficiently strong, the entanglement grows at most
logarithmically in the number of spins. The proof utilises a transformation to
a model of classical probability called the continuum random-cluster model, and
is based on a property of the latter model termed ratio weak-mixing. Our proof
applies equally to a large class of disordered interactions
Field dependence of the vortex structure in chiral p-wave superconductors
To investigate the different vortex structure between two chiral pairing p_x
+(-) i p_y, we calculate the pair potential, the internal field, the local
density of states, and free energy in the vortex lattice state based on the
quasiclassical Eilenberger theory, and analyze the magnetic field dependence.
The induced opposite chiral component of the pair potential plays an important
role in the vortex structure. It also produces H^{1/2}-behavior of the
zero-energy density of states at higher field. These results are helpful when
we understand the vortex states in Sr2RuO4.Comment: 11 pages, 10 figures, to be published in Phys. Rev.
Mast cells, eosinophils and IgE-positive cells in the nasal mucose of patients with vasomotor rhinitis - An immunohistochemical study
Vasomotor rhinitis (VMR) is a disorder of unknown pathogenesis. Forty patients with VMR were carefully selected on the basis of inclusion and exclusion criteria proposed by Mygind and Weeke. Nasal biopsy specimens were taken in the patient group as well as in a group of ten controls. Brush cytology was also taken in the VMR group. Inflammatory cells were identified and counted in the nasal mucosa, with the use of immunohistochemical techniques and a panel of monoclonal antibodies. Eosinophils were studied with the use of BMK13, EG2, and Giemsa. Mast cells were studied with anti-chymase (B7), anti-tryptase (G3) and toluidine blue. Sections were stained with IgE as well. There was no significant difference in the number of eosinophils, mast cells and IgE-positive cells between the two groups. Additionally, in contrast with other reports, in sections that were double-stained with anti-chymase and anti-tryptase, single chymase-positive cells were found
Orientifolds, Unoriented Instantons and Localization
We consider world-sheet instanton effects in N=1 string orientifolds of
noncompact toric Calabi-Yau threefolds. We show that unoriented closed string
topological amplitudes can be exactly computed using localization techniques
for holomorphic maps with involution. Our results are in precise agreement with
mirror symmetry and large N duality predictions.Comment: 25 pages, 10 figures, published version; v4: typos correcte
Early stage scaling in phase ordering kinetics
A global analysis of the scaling behaviour of a system with a scalar order
parameter quenched to zero temperature is obtained by numerical simulation of
the Ginzburg-Landau equation with conserved and non conserved order parameter.
A rich structure emerges, characterized by early and asymptotic scaling
regimes, separated by a crossover. The interplay among different dynamical
behaviours is investigated by varying the parameters of the quench and can be
interpreted as due to the competition of different dynamical fixed points.Comment: 21 pages, latex, 7 figures available upon request from
[email protected]
Bregman Voronoi Diagrams: Properties, Algorithms and Applications
The Voronoi diagram of a finite set of objects is a fundamental geometric
structure that subdivides the embedding space into regions, each region
consisting of the points that are closer to a given object than to the others.
We may define many variants of Voronoi diagrams depending on the class of
objects, the distance functions and the embedding space. In this paper, we
investigate a framework for defining and building Voronoi diagrams for a broad
class of distance functions called Bregman divergences. Bregman divergences
include not only the traditional (squared) Euclidean distance but also various
divergence measures based on entropic functions. Accordingly, Bregman Voronoi
diagrams allow to define information-theoretic Voronoi diagrams in statistical
parametric spaces based on the relative entropy of distributions. We define
several types of Bregman diagrams, establish correspondences between those
diagrams (using the Legendre transformation), and show how to compute them
efficiently. We also introduce extensions of these diagrams, e.g. k-order and
k-bag Bregman Voronoi diagrams, and introduce Bregman triangulations of a set
of points and their connexion with Bregman Voronoi diagrams. We show that these
triangulations capture many of the properties of the celebrated Delaunay
triangulation. Finally, we give some applications of Bregman Voronoi diagrams
which are of interest in the context of computational geometry and machine
learning.Comment: Extend the proceedings abstract of SODA 2007 (46 pages, 15 figures
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How useful is snow accumulation in reconstructing surface air temperature in Antarctica? A study combining ice core records and climate models
Improving our knowledge of the temporal and spatial variability of the Antarctic Ice Sheet (AIS) surface mass balance (SMB) is crucial to reduce the uncertainties of past, present, and future Antarctic contributions to sea level rise. An examination of the surface air temperatureβSMB relationship in model simulations demonstrates a strong link between the two. Reconstructions based on ice cores display a weaker relationship, indicating a modelβdata discrepancy that may be due to model biases or to the non-climatic noise present in the records. We find that, on the regional scale, the modeled relationship between surface air temperature and SMB is often stronger than between temperature and Ξ΄18O. This suggests that SMB data can be used to reconstruct past surface air temperature. Using this finding, we assimilate isotope-enabled SMB and Ξ΄18O model output with ice core observations to generate a new surface air temperature reconstruction. Although an independent evaluation of the skill is difficult because of the short observational time series, this new reconstruction outperforms the previous reconstructions for the continental-mean temperature that were based on Ξ΄18O alone. The improvement is most significant for the East Antarctic region, where the uncertainties are particularly large. Finally, using the same data assimilation method as for the surface air temperature reconstruction, we provide a spatial SMB reconstruction for the AIS over the last 2 centuries, showing large variability in SMB trends at a regional scale, with an increase (0.82βGtβyrβ2) in West Antarctica over 1957β2000 and a decrease in East Antarctica during the same period (β0.13βGtβyrβ2). As expected, this is consistent with the recent reconstruction used as a constraint in the data assimilation
Identifying human interactors of SARS-CoV-2 proteins and drug targets for COVID-19 using network-based label propagation
Motivated by the critical need to identify new treatments for COVID-19,
we present a genome-scale, systems-level computational approach
to prioritize drug targets based on their potential to regulate host-
virus interactions or their downstream signaling targets. We adapt
and specialize network label propagation methods to this end. We
demonstrate that these techniques can predict human-SARS-CoV-2
protein interactors with high accuracy. The top-ranked proteins
that we identify are enriched in host biological processes that are
potentially coopted by the virus. We present cases where our
methodology generates promising insights such as the potential role of
HSPA5 in viral entry. We highlight the connection between
endoplasmic reticulum stress, HSPA5, and anti-clotting agents. We
identify tubulin proteins involved in ciliary assembly that are
targeted by anti-mitotic drugs. Drugs that we discuss are already
undergoing clinical trials to test their efficacy against COVID-19. Our
prioritized list of human proteins and drug targets is available as
a general resource for biological and clinical researchers who are
repositioning existing and approved drugs or developing novel
therapeutics as anti-COVID-19 agents.First author draf
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