4,342 research outputs found
Innovation, endogenous overinvestment, and incentive pay
We analyze how two key managerial tasks interact: that of growing the business through creating new investment opportunities and that of providing accurate information about these opportunities in the corporate budgeting process. We show how this interaction endogenously biases managers toward overinvesting in their own projects. This bias is exacerbated if managers compete for limited resources in an internal capital market, which provides us with a novel theory of the boundaries of the firm. Finally, managers of more risky and less profitable divisions should obtain steeper incentives to facilitate efficient investment decisions
Results of experiments to simulate radiant heating of propellant in a nuclear light bulb engine using a D-C arc radiant energy source
Simulating radiant heating of propellant stream of nuclear light bulb engin
Experimental investigations to simulate the thermal environment, transparent walls, and propellant heating in a nuclear light bulb engine
Simulating thermal environment, transparent walls, and propellant heating in nuclear light bulb engin
Invariant classification of orthogonally separable Hamiltonian systems in Euclidean space
The problem of the invariant classification of the orthogonal coordinate webs
defined in Euclidean space is solved within the framework of Felix Klein's
Erlangen Program. The results are applied to the problem of integrability of
the Calogero-Moser model
M+D: conceptual guidelines for compiling a materials library
This article proposes to present a study conducted by the Raw Materials research group, the results of which comprise the conceptual guidelines for compiling an M+D material library. The study includes the topic, materials and design taking the impact of the changes that came into being in the post industrial era on project methodologies and the search for information regarding materials.
Taking into account the importance and complexity that these relationships have taken on currently, we have studied the issue of materials based on Manzini (1983) and Ashby and Johnson (2002). Afterward different databases and materials libraries located in the Brazil, the United States, France and Italy geared toward design professionals and students were analyzed to understand what information and means of access to them were available. The project methodologies were approached based on Löbach (1991), BĂŒrdeck (1994), Schulmann (1994), Baxter (1998), Dantas (1998 and 2005) and Papanek (1995 and 2000). This study sought to identify the key elements of the role of materials in the project process today, to serve as a parameter for the analysis of the models studied.
A comparative analysis of the models investigated enabled identification of positive and negative aspects to adapt to the needs previously mentioned and identify conceptual guidelines for compiling a collection of materials for use in design projects.
Keywords:
Design, Materials, Project Methodology, Library</p
Sacroiliac Screw Placement with Ease: CT-Guided Pelvic Fracture Osteosynthesis in the Elderly
Background and Objectives: The number of geriatric patients presenting with fragility
fractures of the pelvis is increasing due to ageing Western societies. There are nonoperative and
several operative treatment approaches. Many of which cause prolonged hospitalisation, so patients
become bedridden and lose mobility and independence. This retrospective study evaluates the
postoperative outcome of a computed tomography-guided (CT-guided) minimally invasive approach
of sacroiliac screw osteosynthesis. The particular focus is to demonstrate its ease of use, feasibility
with the equipment of virtually every hospital and beneficial outcomes to the patients. Materials and
Methods: 28 patients (3 men, 25 women, age 80.5 ± 6.54 years) with fragility fractures of the pelvis
types II-IV presenting between August 2015 and September 2021 were retrospectively reviewed. The
operation was performed using the CT of the radiology department for intraoperative visualization
of screw placement. Patients only received screw osteosynthesis of the posterior pelvic ring and
cannulated screws underwent cement augmentation. Outcomes measured included demographic
data, fracture type, postoperative parameters and complications encountered. The quality of life
(QoL) was assessed using the German version of the EQ-5D-3L. Results: The average operation
time was 32.4 ± 9.6 min for the unilateral and 50.7 ± 17.4 for the bilateral procedure. There was no
significant difference between surgeons operating (p = 0.12). The postoperative CT scans were used
to evaluate the outcome and showed only one case of penetration (by 1 mm) of the ventral cortex,
which did not require operative revision. No case of major complication was reported. Following
surgery, patients were discharged after a median of 4 days (Interquartile range 3â7.5). 53.4% of the
patients were discharged home or to rehabilitation. The average score on the visual analogue scale of
the EQ-5D-3L evaluating the overall wellbeing was 55.6 (Interquartile range (IQR) 0â60). Conclusions:
This study shows that the operative method is safe to use in daily practice, is readily available
and causes few complications. It permits immediate postoperative mobilization and adequate pain
control. Independence and good quality of life are preserved
Deep transcranial magnetic stimulation add-on for the treatment of auditory hallucinations: a double-blind study
<p>Abstract</p> <p>Background</p> <p>About 25% of schizophrenia patients with auditory hallucinations are refractory to pharmacotherapy and electroconvulsive therapy. We conducted a deep transcranial magnetic stimulation (TMS) pilot study in order to evaluate the potential clinical benefit of repeated left temporoparietal cortex stimulation in these patients. The results were encouraging, but a sham-controlled study was needed to rule out a placebo effect.</p> <p>Methods</p> <p>A total of 18 schizophrenic patients with refractory auditory hallucinations were recruited, from Beer Yaakov MHC and other hospitals outpatient populations. Patients received 10 daily treatment sessions with low-frequency (1 Hz for 10 min) deep TMS applied over the left temporoparietal cortex, using the H1 coil at the intensity of 110% of the motor threshold. Procedure was either real or sham according to patient randomization. Patients were evaluated via the Auditory Hallucinations Rating Scale, Scale for the Assessment of Positive Symptoms-Negative Symptoms, Clinical Global Impressions, and Quality of Life Questionnaire.</p> <p>Results</p> <p>In all, 10 patients completed the treatment (10 TMS sessions). Auditory hallucination scores of both groups improved; however, there was no statistical difference in any of the scales between the active and the sham treated groups.</p> <p>Conclusions</p> <p>Low-frequency deep TMS to the left temporoparietal cortex using the protocol mentioned above has no statistically significant effect on auditory hallucinations or the other clinical scales measured in schizophrenic patients.</p> <p>Trial Registration</p> <p><b>Clinicaltrials.gov identifier: </b><a href="http://www.clinicaltrials.gov/ct2/show/NCT00564096">NCT00564096</a>.</p
Investigating disturbances of oxygen homeostasis: from cellular mechanisms to the clinical practice
Processing second-order stochastic dominance models using cutting-plane representations
This is the post-print version of the Article. The official published version can be accessed from the links below. Copyright @ 2011 Springer-VerlagSecond-order stochastic dominance (SSD) is widely recognised as an important decision criterion in portfolio selection. Unfortunately, stochastic dominance models are known to be very demanding from a computational point of view. In this paper we consider two classes of models which use SSD as a choice criterion. The first, proposed by Dentcheva and RuszczyĆski (J Bank Finance 30:433â451, 2006), uses a SSD constraint, which can be expressed as integrated chance constraints (ICCs). The second, proposed by Roman et al. (Math Program, Ser B 108:541â569, 2006) uses SSD through a multi-objective formulation with CVaR objectives. Cutting plane representations and algorithms were proposed by Klein Haneveld and Van der Vlerk (Comput Manage Sci 3:245â269, 2006) for ICCs, and by KĂŒnzi-Bay and Mayer (Comput Manage Sci 3:3â27, 2006) for CVaR minimization. These concepts are taken into consideration to propose representations and solution methods for the above class of SSD based models. We describe a cutting plane based solution algorithm and outline implementation details. A computational study is presented, which demonstrates the effectiveness and the scale-up properties of the solution algorithm, as applied to the SSD model of Roman et al. (Math Program, Ser B 108:541â569, 2006).This study was funded by OTKA, Hungarian
National Fund for Scientific Research, project 47340; by Mobile Innovation Centre, Budapest University of Technology, project 2.2; Optirisk Systems, Uxbridge, UK and by BRIEF (Brunel University Research Innovation and Enterprise Fund)
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