Battery system development - Assembly planning between lightweight design and high volume production

Battery systems of electric vehicles suffer from low energy densities as well as high masses and geometrical complexity. The absence of standards for battery cells and peripheral components in combination with large and distributed design spaces within passenger vehicles open up innumerable possibilities to design battery systems. The results are product specific and uneconomical assembly systems. This paper describes the work of the TU Braunschweig to create a methodology that generates and evaluates modular and easy to assemble battery systems based upon user requirements. This methodology gathers and links requirements between the priorities "lightweight design" and "high volume production" including a partly automated generation of CAD data. The generated concepts are directly used for assembly planning. The presented methodology therefore represents a simultaneous engineering approach that shortens development time and supports design engineers as well as process planners

A Novel Predictor Tool of Biochemical Recurrence after Radical Prostatectomy Based on a Five-MicroRNA Tissue Signature

Within five to ten years after radical prostatectomy (RP), approximately 15-34% of prostate cancer (PCa) patients experience biochemical recurrence (BCR), which is defined as recurrence of serum levels of prostate-specific antigen >0.2 µg/L, indicating probable cancer recurrence. Models using clinicopathological variables for predicting this risk for patients lack accuracy. There is hope that new molecular biomarkers, like microRNAs (miRNAs), could be potential candidates to improve risk prediction. Therefore, we evaluated the BCR prognostic capability of 20 miRNAs, which were selected by a systematic literature review. MiRNA expressions were measured in formalin-fixed, paraffin-embedded (FFPE) tissue RP samples of 206 PCa patients by RT-qPCR. Univariate and multivariate Cox regression analyses were performed, to assess the independent prognostic potential of miRNAs. Internal validation was performed, using bootstrapping and the split-sample method. Five miRNAs (miR-30c-5p/31-5p/141-3p/148a-3p/miR-221-3p) were finally validated as independent prognostic biomarkers. Their prognostic ability and accuracy were evaluated using C-statistics of the obtained prognostic indices in the Cox regression, time-dependent receiver-operating characteristics, and decision curve analyses. Models of miRNAs, combined with relevant clinicopathological factors, were built. The five-miRNA-panel outperformed clinically established BCR scoring systems, while their combination significantly improved predictive power, based on clinicopathological factors alone. We conclude that this miRNA-based-predictor panel will be worth to be including in future studies

Consumer perception of food products involving genetic modification: Results from a qualitative study in four Nordic countries

1. The present study addresses consumer acceptance of food products involving the use of different applications of genetic modification in four Nordic countries. Three food products were used as examples: hard cheese, hard candy, and salmon. Three types of applications of genetic modification were investigated: modification of the raw material, use of genetic modification in enzyme production, and direct use of genetically modified microorganisms. In addition, three levels of presence of the genetically modified material in the final product were investigated: not present, present, and present and living/able to function. 2. The results from consumer samples in Denmark, Finland, Norway and Sweden are remarkably similar, showing a strong stability in consumer reactions to the use of genetic modification in food production in these four countries. 3. Consumer perception is characterised by a basic dichotomy of GM and non-GM products. Being non-GM is regarded as a major benefit in itself. When a product involves genetic modification, this elicits numerous negative assocations, of which the strongest ones are ‘unhealthy’ and ‘uncertainty.’ 4. The level of presence of the genetically modified material in the final product has a clear impact on consumer acceptance. When the GM material is present and viable/able to function, acceptance is lowest. 5. The type of application of genetic modification has an impact on consumer acceptance as well, but it differs across products. Still, there is a clear tendency that acceptance of salmon products where the salmon itself was genetically modified was lowest among all products tested. 6. The consumer benefits which the application of GM brings about (e.g., improved taste, functional benefits, environmental benefits) are largely perceived, but cannot overcompensate for the negative associations to GM. In some cases, a supposed benefit (e.g., faster growth of salmon, leading to reduced energy costs) was actually perceived as a disadvantage. Benefits combining personal tangible benefits with societal relevance (e.g., a low calorie candy which can be consumed by people suffering from diabetes) may have most positive impact on consumer acceptance.Consumer behaviour; Buying behaviour; Food; Denmark; Norway; Sweden; Finland

Novel form-flexible handling and joining tool for automated preforming

The production rates of carbon fiber reinforced plastic (CFRP) parts are rising constantly which in turn drives research to bring a higher level of automation to the manufacturing processes of CFRP. Resin transfer molding (RTM), which is seen as a production method for high volumes, has been accelerated to a high degree. However, complex net-shape preforms are necessary for this process, which are widely manually manufactured. To face these challenges a new concept for the manufacturing of carbon fiber preforms with a form-flexible gripping, draping and joining end-effector is presented and discussed. Furthermore, this paper investigates the application of this concept, describes the initial build-up of a demonstrator, focusing on material selection and heating technology, and discusses test results with the prototype. This prototype already validates the feasibility of the proposed concept on the basis of a generic preform geometry. After a summary, this paper discusses future in-depth research concerning the concept and its application in more complex geometries. © 2015 by De Gruyter 2015

Disassembly of electric vehicle batteries using the example of the Audi Q5 hybrid system

The rising number of electric vehicles comes along with an increasing demand for Li-Ion batteries. As resources such as lithium are valuable it is economically worthwhile to recycle EV batteries. One of the first steps of every battery recycling process is the disassembly, which can be a quite time and cost consuming process and hence has to be planned properly. Using the battery of the hybrid car Audi Q5 as a case study, a planning approach for the disassembly will be discussed in this paper. Therefore, disassembly sequences will be derived from a priority matrix and a disassembly graph will be drawn up. Finally, recommendations for the design of the disassembly system and work stations will be given.Audi AG and Electrocycling GmbHAutomotive Research Center Niedersachsen (NFF)German Federal Ministry for the Environment, Nature Conservation and Nuclear Safet

Circular RNAs in Clear Cell Renal Cell Carcinoma: Their Microarray-Based Identification, Analytical Validation, and Potential Use in a Clinico-Genomic Model to Improve Prognostic Accuracy

Circular RNAs (circRNAs) may act as novel cancer biomarkers. However, a genome-wide evaluation of circRNAs in clear cell renal cell carcinoma (ccRCC) has yet to be conducted. Therefore, the objective of this study was to identify and validate circRNAs in ccRCC tissue with a focus to evaluate their potential as prognostic biomarkers. A genome-wide identification of circRNAs in total RNA extracted from ccRCC tissue samples was performed using microarray analysis. Three relevant differentially expressed circRNAs were selected (circEGLN3, circNOX4, and circRHOBTB3), their circular nature was experimentally confirmed, and their expression-along with that of their linear counterparts-was measured in 99 malignant and 85 adjacent normal tissue samples using specifically established RT-qPCR assays. The capacity of circRNAs to discriminate between malignant and adjacent normal tissue samples and their prognostic potential (with the endpoints cancer-specific, recurrence-free, and overall survival) after surgery were estimated by C-statistics, Kaplan-Meier method, univariate and multivariate Cox regression analysis, decision curve analysis, and Akaike and Bayesian information criteria. CircEGLN3 discriminated malignant from normal tissue with 97% accuracy. We generated a prognostic for the three endpoints by multivariate Cox regression analysis that included circEGLN3, circRHOBT3 and linRHOBTB3. The predictive outcome accuracy of the clinical models based on clinicopathological factors was improved in combination with this circRNA-based signature. Bootstrapping as well as Akaike and Bayesian information criteria confirmed the statistical significance and robustness of the combined models. Limitations of this study include its retrospective nature and the lack of external validation. The study demonstrated the promising potential of circRNAs as diagnostic and particularly prognostic biomarkers in ccRCC patients

Form-flexible handling and joining technology (formhand) for the forming and assembly of limp materials

The assembly of limp, elastic or differently shaped objects poses a huge challenge which needs to be met by machine tools and the corresponding processes of handling, forming and joining. These processes are often carried out manually. This technological gap triggered the present work at the Technische Universität Braunschweig. A novel form-flexible handling tool (FormHand) is presented which focuses on the automation of these production steps taking into consideration the material behavior. The combination of the flexibility of both industrial robot and the FormHand end-effector allows for new processes appropriate for these materials. This article investigates the used materials of the granular filler and the cushion textile, the working states of FormHand and the use of online sensors for an automated process application