Bounding Box Annotation with Visible Status

Training deep-learning-based vision systems requires the manual annotation of a significant amount of data to optimize several parameters of the deep convolutional neural networks. Such manual annotation is highly time-consuming and labor-intensive. To reduce this burden, a previous study presented a fully automated annotation approach that does not require any manual intervention. The proposed method associates a visual marker with an object and captures it in the same image. However, because the previous method relied on moving the object within the capturing range using a fixed-point camera, the collected image dataset was limited in terms of capturing viewpoints. To overcome this limitation, this study presents a mobile application-based free-viewpoint image-capturing method. With the proposed application, users can collect multi-view image datasets automatically that are annotated with bounding boxes by moving the camera. However, capturing images through human involvement is laborious and monotonous. Therefore, we propose gamified application features to track the progress of the collection status. Our experiments demonstrated that using the gamified mobile application for bounding box annotation, with visible collection progress status, can motivate users to collect multi-view object image datasets with less mental workload and time pressure in an enjoyable manner, leading to increased engagement.Comment: 10 pages, 16 figure

Catalytic Activation of 1‑Cyano-3,3-dimethyl-3-(1<i>H</i>)‑1,2-benziodoxole with B(C₆F₅)₃ Enabling the Electrophilic Cyanation of Silyl Enol Ethers

The Lewis acidic activation of a hypervalent iodine reagent containing a transferable cyano group, 1-cyano-3,3-dimethyl-3-(1<i>H</i>)-1,2-benziodoxole (CDBX), with B­(C₆F₅)₃, to achieve the catalytic electrophilic cyanation of silyl enol ethers is presented. Mechanistic studies indicate that CDBX is activated through coordination of its cyano group to B­(C₆F₅)₃, thus enabling the electrophilic cyanation reaction to occur

Recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia

急性骨髄性白血病の新規遺伝子変異を発見 --乳がんの既存薬が治療に有効である可能性--. 京都大学プレスリリース. 2018-11-01.In acute myeloid leukemia (AML), MLL (KMT2A) rearrangements are among the most frequent chromosomal abnormalities; however, knowledge of the genetic landscape of MLL-rearranged AML is limited. In this study, we performed whole-exome sequencing (n = 9) and targeted sequencing (n = 56) of samples from pediatric MLL-rearranged AML patients enrolled in the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 study. Additionally, we analyzed 105 pediatric t(8;21) AML samples and 30 adult MLL-rearranged AML samples. RNA-sequencing data from 31 patients published in a previous study were also reanalyzed. As a result, we identified 115 mutations in pediatric MLL-rearranged AML patients (2.1 mutations/patient), with mutations in signaling pathway genes being the most frequently detected (60.7%). Mutations in genes associated with epigenetic regulation (21.4%), transcription factors (16.1%), and the cohesin complex (8.9%) were also commonly detected. Novel CCND3 mutations were identified in 5 pediatric MLL-rearranged AML patients (8.9%) and 2 adult MLL-rearranged AML patients (3.3%). Recurrent mutations of CCND1 (n = 3, 2.9%) and CCND2 (n = 8, 7.6%) were found in pediatric t(8;21) AML patients, whereas no CCND3 mutations were found, suggesting that D-type cyclins exhibit a subtype-specific mutation pattern in AML. Treatment of MLL-rearranged AML cell lines with CDK4/6 inhibitors (abemaciclib and palbociclib) blocked G1 to S phase cell-cycle progression and impaired proliferation. Pediatric MLL-MLLT3–rearranged AML patients with coexisting mutations (n = 16) had significantly reduced relapse-free survival and overall survival compared with those without coexisting mutations (n = 9) (P = .048 and .046, respectively). These data provide insights into the genetics of MLL-rearranged AML and suggest therapeutic strategies

Precision spectroscopy of pionic atoms and chiral symmetry in nuclei

We conduct an experimental project to make spectroscopy of deeply bound pionic atoms systematically over wide range of nuclei. We aim at studying the strong interaction in the low energy region, which has close connection to spontaneous chiral symmetry breaking and its partial restoration in nuclear matter. First experimental results show improved spectral resolution and much better statistical sensitivity than previous experiments. Present status of the experiment is reported