Anti-inflammatory activity of Anthemis tricolor Boiss

WOS: 000506827300006PubMed: 31997994Introduction: Traditionally, Anthemis genus has been used for the treatment of gastrointestinal disorders, haemorrhoid and stomach ache in Europe. There are several in-vitro and in-vivo studies that showed the pharmacological properties of Anthemis species such as antibacterial, anti-inflammatory, antiedemic and hepatoprotective properties. Aim: Our study referred to the model of inflammation formed in rats; we aimed to evaluate anti-inflammatory properties of A. tricolor extracts. Material and methods: Five different extracts of A. tricolor were tested against the negative control and 2 different topical corticosteroids (betamethasone and hydrocortisone); n-hexane and sesquiterpene extracts of A. tricolor Bois showed significantly reduced erythema compared to the negative control. Results: Only n-hexane and sesquiterpene extracts of A. tricolor have the anti-inflammatory effect. Conclusions: This is the first report on anti-inflammatory activity of A. tricolor and we showed an anti-inflammatory effect of n-hexane and sesquiterpene extract of A. tricolor with UV erythema test as a_result, hence A. tricolor extracts can be used for the treatment of inflammatory skin diseases due to anti-inflammatory activity

Eco-friendly Sensors Developed by Herbal Based Silver Nanoparticles for Electrochemical Detection of Mercury (II) Ion

WOS: 000474252600011In our study, the single-use & eco-friendly electrochemical sensor platform based on herbal silver nanoparticles (AgNPs) was developed for detection of mercury (II) ion (Hg2+). For this purpose, the surface of pencil graphite electrode (PGE) was modified with AgNPs and folic acid (FA), respectively. The concentrations of AgNPs and FA were firstly optimized by differential pulse voltammetry (DPV) to obtain an effective surface modification of PGE. Each step at the surface modification process was characterized by using cyclic voltammetry (CV) and electrochemical impedence spectroscopy (EIS). The limit of detection (LOD) for Hg2+ was estimated and found to be 8.43 mu M by CV technique. The sensor presented an excellent selectivity for Hg2+ against to other heavy metal ions such as Ca2+, Cd2+, Cr3+, Cu2+, Mg2+, Ni2+, Pb2+, Zn2+, Co2+ and Mn2+. Moreover, a rapid, selective and sensitive detection of Hg2+ was successfully performed in the samples of tap water within 1 min.Turkish Academy of Sciences (TUBA)Turkish Academy of SciencesA.E. would like to express her gratitude to the Turkish Academy of Sciences (TUBA) as a Principal member for its partial support

Fatty acids and antioxidant capacities of three Centaurea L. species

The aim of this study is to determine the fatty acid compositions and antioxidant activities of three Centaurea species as Centaurea iberica, C. urvillei ssp. hayekiana, and C. urvillei ssp. nimrodis and compare them with each other. As a result of fatty acid determination by GC MS method, oleic acid and linoleic acid were found as the main fatty acids in these Centaurea species. Polyunsaturated fatty acids (PUFAs) were determined at 58.66%, 46.98%, 62.22% in C. iberica, C. urvillei ssp. hayekiana and C. urvillei ssp. nimrodis, respectively. Antioxidant activities of methanolic extracts of three Centaurea species were evaluated by DPPH, ABTS and CUPRAC assays. The methanol extract of C. urvillei ssp hayekiana showed the highest antioxidant activity in direct proportion to the total amount of phenolic and flavonoid substances. The fact that the antioxidant activities of these three species and fatty acid analyzes have not been compared in previous studies is important in that this study is the first

Fatty Acid Composition of the Aerial Parts of Some Centaurea Species in Elazig, Turkey

WOS: 000339624700019Purpose: To evaluate the fatty acid composition of six Centaurea species, viz, Centaurea behen, C. saligna, C. depressa, C. urvillei subsp. urvillei, C. urvillei subsp. hayekiana and C. aggregata subsp. aggregata, from Elazig, Turkey. Methods: Fatty acid methyl esters (FAMEs) of the oil extracts of four Centaurea species were prepared. The fatty acid compositions of Centaurea species were analyzed by gas chromatography (GC). Results: Saturated fatty acids (SFAs) in Centaurea species and subspecies ranged from 24.61 - 50.92% of their total fatty acid content, while monounsaturated fatty acids (MUFAs) were in the range of 3.40 - 37.96% and polyunsaturated fatty acids (PUFAs) 12.21 - 20.57%. Palmitic acid C 16: 0, oleic acid C 18:1 omega 9 and linoleic acid C 18:1 omega 3 were the major fatty acids in all the species. Oleic acid was the main constituent of C. urvillei subps. urvillei and C. agrregata subsp. aggregata with a content of 26.92 and 50.92%, respectively. Conclusion: The oil extracted from Centaurea species is a good source of essential fatty acids.Ege University Faculty of Pharmacy Pharmaceutical Sciences Research Centre (FABAL, Izmir, Turkey)Ege University; Ege University Research Fund, Izmir, TurkeyEge University [13/ECZ/031]The authors would like to thank the authorities of Ege University Faculty of Pharmacy Pharmaceutical Sciences Research Centre (FABAL, Izmir, Turkey) and Ege University Research Fund, Izmir, Turkey (grant no. 13/ECZ/031) for support for this work

Anti-inflammatory activity of Anthemis aciphylla var. aciphylla Boiss.

WOS: 000298197800014Ethanolic (EEAA) and sesquiterpene lactone (SEAA) extracts of the aerial parts of Anthemis aciphylla var. aciphylla Boiss. (Asteraceae) were evaluated for anti-inflammatory activity on carrageenin-induced paw edema (acute model) and cotton pellet-induced granuloma (chronic model) in rats. In carrageenin-induced paw edema, EEAA and SEAA at intraperitoneal doses of 50, 100, and 200 mg/kg dose-dependently inhibited the paw edema. In cotton pellet-induced granuloma, the oral administration of EEAA and SEAA at 50, 100, and 200 mg/kg dosages was also found to significantly inhibit granuloma tissue formation.Ege University, Izmir, TurkeyEge University [2008/ECZ/001]This research was supported by Ege University's Research Fund (No. 2008/ECZ/001), Izmir, Turkey

Green synthesis of silver nanoparticles using Arbutus andrachne leaf extract and its antimicrobial activity

WOS: 000381930900003Purpose: To synthesize silver nanoparticles (AgNPs) of Arbutus andrachne leaf water extract (LE) and to evaluate the antimicrobial activity of both LE and AgNPs. Methods: The synthesized AgNPs were characterized using the following techniques: ultraviolet-visible spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), X-ray diffraction (XRD) analysis, and analysis of particle size (PS) and zeta potential (ZP). The antimicrobial activities of LE and NPs were assessed by Kirby-Bauer disc diffusion (DD) and broth microdilution (MD) methods according to the recommendations of the Clinical and Laboratory Standards Institute (CLSI). LE and AgNPs were examined against fresh cultures of four Gram-positive and five Gram-negative bacteria, and three yeast strains. Results: AgNPs were successfully synthesized and characterized using Arbutus andrachne LE. The AgNPs showed moderate antibacterial activity against Staphylococcus aureus ATCC 6538p, S. epidermidis ATCC 12228, Escherichia coli ATCC 29998, Klebsiella pnemoniae ATCC 13883 and Pseudomonas aeruginosa ATCC 27853, and also antifungal activity against Candida albicans ATCC 10239 and C. krusei ATCC 6258. Conclusions: Due to the potent activity of AgNPs against Gram-positive and Gram-negative bacteria, and yeast strains, it is suggested that AgNPs are potential broad spectrum antimicrobial agents