The Enframing of Code: Agency, originality and the plagiarist

This paper is about the phenomenon of encoding, more specifically about the encoded extension of agency. The question of code most often emerges from contemporary concerns about the way digital encoding is seen to be transforming our lives in fundamental ways, yet seems to operate ‘under the surface’ as it were. In this essay I suggest that the performative outcomes of digital encoding are best understood within a more general horizon of the phenomenon of encoding – that is to say as norm- or rule-governed material enactments accepted (or taken for granted) as the necessary conditions for becoming. Encoded material enactments translate/extend agency, but never exactly. I argue that such encoded extensions are insecure, come at a cost and are performative. To illustrate this I present a brief discussion of some specific historical transitions in the encoding of human agency: from speech to writing, to mechanical writing, and finally to electronic writing. In each of these translations I aim to show that agency is translated/extended in ways that have many unexpected performative outcomes. Specifically, through a discussion of the digital encoding of writing, as reuse, I want to suggest the proposition that all agency is always borrowed (or ‘plagiarized’) – i.e. it is never originally human. As encoded beings we are never authors, we are rather more or less skilful reusers. To extend agency we have to submit to the demands of encoding and kidnap that encoding simultaneously – enabling constraints in Butler’s language. Our originality, if there is any, is in our skill at kidnapping the code and turning it into an extension of our agency, that is to say, our skill at resignification – to be original we need to be skilful ‘parasites’, as suggested by Serres

Effectiveness and causes for failure of surveillance of CDKN2A-mutated melanoma families

Background. For more than 25 years families with an increased susceptibility to melanoma have been under surveillance at our institution. Objective: We sought to investigate the effectiveness of surveillance for CDKN2A-mutated families and causes for failure of the program in patients with more advanced tumors. Methods: In a retrospective case-control study, Breslow thickness of melanomas diagnosed in relatives enrolled in the surveillance program were compared with melanomas of unscreened index patients. We investigated the influence of mode of detection and length of surveillance interval on outcome. Results: Surveillance melanomas (n = 226, median thickness: 0.50 mm) had a significantly lower Breslow thickness (multiplication factor: 0.61 [95% confidence interval 0.47-0.80], P < .001) than index melanomas (n = 40, median thickness: 0.98 mm). Index melanomas were more likely diagnosed with a Breslow thickness greater than 1.0 mm (odds ratio: 3.1 [95% confidence interval 1.2-8.1], P = .022). In all, 53% of. surveillance melanomas were diagnosed during regular screens, 7% during patients' first screen, 20% between regular screens, and 20% in patients who were noncompliant with the surveillance schedule. The majority of surveillance melanomas (58%) were detected within 6 months after the last screen. There was no correlation between tumor thickness and the length of the screening interval for tumors diagnosed within 24 months since the last screen. Limitations: The study is retrospective. Conclusions: Surveillance was associated with earlier detection of melanomas. Noncompliance was an important cause for failing surveillance. Shortening surveillance intervals may advance detection of tumors, but may paradoxically have little impact on prognosis. (J Am Acad Dermatol 2011;65:289-96.)Dermatology-oncolog

Reassembling social science methods: the challenge of digital devices

The aim of the article is to intervene in debates about the digital and, in particular, framings that imagine the digital in terms of epochal shifts or as redefining life. Instead, drawing on recent developments in digital methods, we explore the lively, productive and performative qualities of the digital by attending to the specificities of digital devices and how they interact, and sometimes compete, with older devices and their capacity to mobilize and materialize social and other relations. In doing so, our aim is to explore the implications of digital devices and data for reassembling social science methods or what we call the social science apparatuses that assemble digital devices and data to 'know' the social and other relations. Building on recent work at CRESC on the social life of methods, we recommend a genealogical approach that is alive to the ways in which digital devices are simultaneously shaped by social worlds, and can in turn become agents that shape those worlds. This calls for attending to the specificities of digital devices themselves, how they are varied and composed of diverse socio-technical arrangements, and are enrolled in the creation of new knowledge spaces, institutions and actors. Rather than exploring what large-scale changes can be revealed and understood through the digital, we argue for explorations of how digital devices themselves are materially implicated in the production and performance of contemporary sociality. To that end we offer the following nine propositions about the implications of digital data and devices and argue that these demand rethinking the theoretical assumptions of social science methods: transactional actors; heterogeneity; visualization; continuous time; whole populations; granularity; expertise; mobile and mobilizing; and non-coherence