152 research outputs found

    Térinformatika az erdővédelem szolgálatában

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    Acute escitalopram treatment inhibits REM sleep rebound and activation of MCH-expressing neurons in the lateral hypothalamus after long term selective REM sleep deprivation.

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    RATIONALE: Selective rapid eye movement sleep (REMS) deprivation using the platform-on-water ("flower pot") method causes sleep rebound with increased REMS, decreased REMS latency, and activation of the melanin-concentrating hormone (MCH) expressing neurons in the hypothalamus. MCH is implicated in the pathomechanism of depression regarding its influence on mood, feeding behavior, and REMS. OBJECTIVES: We investigated the effects of the most selective serotonin reuptake inhibitor escitalopram on sleep rebound following REMS deprivation and, in parallel, on the activation of MCH-containing neurons. METHODS: Escitalopram or vehicle (10 mg/kg, intraperitoneally) was administered to REMS-deprived (72 h) or home cage male Wistar rats. During the 3-h-long "rebound sleep", electroencephalography was recorded, followed by an MCH/Fos double immunohistochemistry. RESULTS: During REMS rebound, the time spent in REMS and the number of MCH/Fos double-labeled neurons in the lateral hypothalamus increased markedly, and REMS latency showed a significant decrease. All these effects of REMS deprivation were significantly attenuated by escitalopram treatment. Besides the REMS-suppressing effects, escitalopram caused an increase in amount of and decrease in latency of slow wave sleep during the rebound. CONCLUSIONS: These results show that despite the high REMS pressure caused by REMS deprivation procedure, escitalopram has the ability to suppress REMS rebound, as well as to diminish the activation of MCH-containing neurons, in parallel. Escitalopram caused a shift from REMS to slow wave sleep during the rebound. Furthermore, these data point to the potential connection between the serotonergic system and MCH in sleep regulation, which can be relevant in depression and in other mood disorders

    Application of GIS for a Climate Change Prepared Disaster Management in Csongrád County, Hungary

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    The work of disaster management can only properly be supported by data stored in certified databases, since correct decisions can be made on the base of such data. Nowadays these data can be found in databases managed by several organisations, or only a part of the necessary data is available through GIS services. The tasks of disaster management include prevention, i.e. the preparation for potential incidents and the elaboration of related scenarios and plans taking into consideration the altering risk landscape caused by climate change. The development of modelling processes and applications based on GIS databases and the integration of the results in work processes gain ground more and more in this work phase. Geoinformatics is able to provide support for decision-making in two ways: in strategic planning and in the operative task solution. The present study demonstrates a multi-hazard multi-scale GIS tool development in Csongrád County (Hungary) in accordance with the aims of the Sendai Framework. This geoinformatic tool is applicable to support the decision-making not only of the management board but the deployed rescue units in case of an evacuation through the optimized locations of the gathering places
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