Lung adenocarcinoma with micropapillary component presenting with metastatic scrotum tumor and cancer-to-cancer metastasis: A case report

A 54-year-old man was admitted to the hospital presenting with a 3-month history of sclerosing dermal lesion in the external genitalia. A scrotal skin biopsy revealed a poorly-differentiated adenocarcinoma, immunohistochemically positive for cytokeratin 7 (CK7) and for thyroid transcription factor 1 (TTF-1), and negative for CK20. One month after admission, he died of respiratory failure. At autopsy, a consolidating lesion with vague margin was noted in the left lung as well as a well-circumscribed nodule in the right lobe of the thyroid. Histopathologically, pulmonary lesion was adenocarcinoma with a micropapillary component. On the other hand, thyroid tumor was diagnosed as a follicular variant of papillary carcinoma with foci of micropapillary adenocarcinoma. Positive immunohistochemistry for surfactant protein on micoropapillary component was useful to confirm that micropapillary component was of lung adenocarcinoma origin

Fetal nuchal cystic hygroma associated with aortic coarctation and trisomy 21: a case report

We report a case of fetal nuchal cystic hygroma associated with aortic coarctation and trisomy 21. A stillborn baby, delivered at 15 weeks and 5 days of gestation, had a huge nuchal cystic hygroma. Autopsy revealed aortic coarctation of the periductal type with patent ductus arteriosus, endocardial cushion defect and left ventricular hypoplasia. Trisomy 21 was evident by karyotyping. Macroscopically, while an apparent association of nuchal cystic hygroma and aortic coarctation resembled Turner syndrome, histopathological findings were those typically seen in trisomy 21: numerous dilated lymphatics in the subcutaneous tissue with severe mesenchymal edema, and an enlarged jugular lymphatic sac

Mössbauer Spectroscopic Study on Hofmann-like Coordination Polymer Fe(4-Clpy)2[Ni(CN)4]

57Fe Mössbauer spectroscopic results on the 2D Hofmann-like coordination polymer Fe(4-Clpy)2Ni(CN)4 (sample 1) indicate that iron(II) ions are in a high spin state both at R.T. and T = 80 K, showing that the compound exhibits no spin crossover (SCO) behavior. Mössbauer spectra at R.T. and T = 80 K show one major doublet which corresponds to the HS1 is due to high spin iron(II) sites coordinated by four N atoms of cyano groups and two N atoms of 4-Clpy ligand in the sample 1. Two minor doublets coexisted in sample 1. One minor doublet with a large quadrupole splitting can be explained by the presence of defects in the coordination polymer frameworks. Another minor doublet is with a small quadrupole splitting, indicating the presence of iron(III) high spin species or iron(II) low spin species. This work is licensed under a Creative Commons Attribution 4.0 International License

Swine Intestinal Immunity via Toll-like Receptors and Its Advanced Application to Food Immunology

Recent interest has focused on the importance of intestinal immunity for the host defense, but to date, not much has been known about the underlying mechanisms. Toll-like receptor (TLR) family plays an important role in the defense through recognizing bacterial pathogen associated molecular patterns (PAMPs). Our research on the bioregulatory function of food products has investigated the immunoregulatory effects of lactic acid bacteria (LAB) via TLRs. Studies in swine, which is expected as a human model, have been examined intestinal immunoregulation by the LAB. Our research has now demonstrated modulation of intestinal immunity mediated by TLRs in Peyer\u27s patches and the mesenteric lymph nodes. On the basis of our study, efforts have also been made to develop an immunoassay system for immunobiotic LAB DNA and cell wall components to evaluate immunoregulation by the LAB via TLRs. The findings in our research activities may provide important clues at the molecular level on TLR signal transduction pathways and recognition mechanisms. They also provide impetus to further delineate the activation mechanism of the innate immune response. In addition, identification of biofactors from LAB with immunoactivity, and better understanding of cytokine induction and intestinal immune regulation hold promise in basic research and development of "immunobiotic foods" to prevent specific diseases

Dioxidobis(pentane-2,4-dionato-κ2 O,O′)(pyridine-4-carbaldehyde oxime-κN 1)uranium(VI)

The title compound, [U(C5H7O2)2O2(C6H6N2O)], exhibits a penta­gonal–bipyramidal coordination geometry around the UVI atom, involving two bidentate acetyl­acetonate ions and the pyridine ring of the pyridine-4-carbaldehyde oxime ligand. Hydrogen bonds exist between the OH group of the pyridine-4-carbaldehyde oxime ligand and the two O atoms of the acetyl­acetonate ions

Aqua­dioxidobis(pentane-2,4-dionato)uranium(VI) pyrazine solvate

The asymmetric unit of the title compound, [U(C5H7O2)2O2(H2O)]·C4H4N2, contains one [UO2(acac)2(H2O)] (where acac is acetyl­acetonate) and two half-mol­ecules of pyrazine. It exhibits a UO7 penta­gonal-bipyramidal coordination geometry about the UVI atom, involving two bidentate acetyl­acetonate ions and one water mol­ecule. The N atoms of the pyrazine mol­ecules are not coordinated to the UVI atom, and are connected with the aqua O atom by hydrogen bonds. This results in a zigzag chain arrangement along the [10] direction

Editorial: Nutrition, Immunity and Viral Infections

Viral infectious diseases have a great impact on humankind. Pandemic, epidemic, and endemic viral diseases produce considerable morbidity and mortality, negatively affecting not only health and well-being but also local and global economies by increasing school and work absenteeism as well as the healthcare system expenses. Probably the best example of this global threat is the infectious disease caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which has infected millions of people globally during the 2019-2020 pandemic [WHO, coronavirus pandemic; (1)]. Viral infections not only affect the economy in terms of human life, they also induce losses in livestock and crops (2), and can break down the barriers between animals and people, creating new potential dangers to human health (3). The SARS-CoV-2 pandemic pushed healthcare systems around the world to the limit and put pressure on the scientific community to provide solutions that help to prevent or alleviate its harmful effects. In consequence, in the past few months, there has been a reevaluation of the work of scientists actively investigating the biological features of viral infections, as well as potential preventive and therapeutic tools to combat them.Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Shimosato, Takeshi. Shinshu University; JapónFil: Vizoso Pinto, María Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Kitazawa, Haruki. Tohoku University; Japó

Fatal cardiac tamponade due to coronary sinus thrombosis in acute lymphoblastic leukaemia: a case report

We report a rare case of fatal cardiac tamponade attributed to coronary sinus thrombosis. An 83-year-old man was admitted to the hospital complaining of general fatigue. Laboratory examination revealed marked increase of atypical lymphoblastic cells in peripheral blood. CHOP therapy was started under the diagnosis of acute lymphoblastic leukemia. The patient died, however, of sudden cardiac arrest in the initial course of the chemotherapy. Autopsy revealed cardiac tamponade with markedly dilated and congested coronary vein induced by coronary sinus thrombosis. A condition similar to leukemia-related venous thromboembolic disease, combined with endothelial damage induced by leukemic infiltration, may cause this rare complication