Thermal Properties of Hemp Fiber Reinforced Plant-Derived Polyamide Biomass Composites and their Dynamic Viscoelastic Properties in Molten State

To further enhance the mechanical, thermal, and tribological properties of short natural fiber-reinforced biopolymer composites, it is very critical to understand thermal properties of these biomass composites and their dynamic viscoelastic properties in the molten state. The aim of this study is to experimentally investigate the thermal properties of hemp fiber filled plant-derived polyamide 1010 composites and their dynamic viscoelastic properties in the molten state. It was found that the addition of HF with PA1010 has a strong influence on the thermal properties such as DMA, TGA, and DSC. HF is very effective for improving the thermal and mechanical properties. The effect of alkali treatment on the dynamic viscoelastic properties of the HF/PA1010 composites in the molten state differs according to whether alkali treatment uses silane coupling agent or not. The viscoelastic properties of NaClO2 are higher than those of NaOH. Silane coupling agents have a remarkable influence on rheological properties such as storage modulus, loss modulus, and complex viscosity in the low angular frequency region in the molten state, temperature dependences of rheological properties, and relationship between the phase angle and complex modulus. These rheological behaviors are also strongly influenced by the type of silane coupling agents

Demonstration of local expansion toward large-scale entangled webs

We demonstrate an optical gate that increases the size of polarization-based W states by accessing only one of the qubits. Using this gate, we have generated three-photon and four-photon W states with fidelities $0.836\pm 0.042$ and $0.784\pm 0.028$, respectively. We also confirmed existence of pairwise entanglement in every pair of the qubits including the one that was left untouched by the gate. The gate is applicable to any size of W states and hence is a universal tool for expanding entanglement.Comment: 5 pages, 4 figure

Thermal properties of hemp fiber filled polyamide 1010 biomass composites and the blend of these composites and polyamide 11 elastomer

The aim of this study is to improve the performance of all inedible plants-derived materials for new engineering materials such as structural materials and tribomaterials. Thermal properties of hemp fiber tilled polyamide 1010 biomass composites and the blend of these composites and plants-derived TPE, were investigated experimentally. These biomass composites were extruded by a twin screw extruder and compression or injection molded. Thermal properties such as dynamic mechanical analysis (DMA), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) of these biomass composites were evaluated. It was found that the addition of HF and the blend of bio-TPE With PA1010 have strong influence on the thermal properties such as DMA, TGA and DSC. In particular, IT has a good effect for the improvement of the thermal and mechanical properties. These properties of HF/PA1010/PA11E biomass composites are better than those of HF/PA1010/ITU ones

Influence of types of alkali treatment on the mechanical properties of hemp fiber reinforced polyamide 1010 composites

In order to develop the new engineering materials such as structural materials and tribomaterials based on all plants-derived materials, the purpose of this study is to investigate the influence of types of alkali treatment on the mechanical and tribological properties of hemp fiber (HF) reinforced plants-derived polyamide 1010 (HF/PA1010) biomass composites. HF were surface-treated by four types of surface treatments: (a) alkali treatment by sodium hydroxide (NaOH) solution, (b) alkali treatment by sodium chlorite (NaClO2) solution, (c) alkali treatment by NaOH solution and surface treatment by ureido silane coupling agent, and (d) alkali treatment by NaClO2 solution and surface treatment by ureido silane. The volume fraction of hemp fiber in the composites was fixed with 20vol.%. HF/PA1010 composites were extruded by a twin screw extruder and injection-molded. Mechanical properties such as tensile, bending and tribological properties by ring-on-plate type sliding wear testing were evaluated. It was found that the effect of the types of alkali treatment on the mechanical and tribological properties of the composites differed for each property. The mechanical and tribological properties are improved with both alkali treatments by NaOH and NaClO2 with or without the surface treatment by ureido silane coupling agent (A-1160). This may be attributed to the interfacial interaction and interphase adhesion between HF and PA1010 according to the type of these alkali treatments. The combination NaClO2 and A-1160 is the most effect improvement for the mechanical and tribological properties of HF/PA1010 biomass composites. It follows from these results that it may be possible to develop the new engineering materials with sufficient balance between mechanical and tribological properties. © 2016 Author(s)

Effect of processing sequence on the dynamic viscoelastic properties of ternary biomass composites (Hemp fiber/PA1010/PA11E) in the molten state

For developing the new engineering materials such as structural materials and tribomaterials based on all plants-derived materials, we investigated the effect of processing sequence on the dynamic viscoelastic properties of the ternary biomass composites: 5mm cut hemp fiber (HF) filled polymer blend of plants-derived polyamide 1010 (PA1010) and polyamide 11 elastomer (PA11E) composites in the molten state. PA1010 and PA11E, which contain the polyether groups as soft segment, were made from plant-derived castor oil. The composition of the polymer blend of PA1010 and PA11E was fixed with 60/40 weight fraction. HF was surface-treated by two types of treatment: alkali treatment by NaOH solution and surface treatment by ureido silane coupling agent. The volume fraction of HF in the composites was fixed with 20vol.%. Five different processing sequences: (1) HF, PA1010 and PA11E were mixed simultaneously (Process A), (2) Re-mixing (second compounding) of the materials prepared by Process A (Process AR), (3) PA11E was blended with PA1010 (PA1010/PA11E blends) and then these blends were mixed with HF (Process B), (4) HF was mixed with PA1010 (HF/PA1010 composites) and then these composites were blended with PA11E (Process C), and (5) HF were mixed with PA11E (HF/PA11E composites) and then these composites were blended with PA1010 (Process D) were attempted for preparing the ternary biomass composites (HF/PA1010/PA11E) composites. These ternary biomass composites were extruded by a twin screw extruder and compression-molded. Their dynamic viscoelastic properties in the molten state were evaluated by oscillatory flow testing using a parallel plate type rheometer. It was found that those properties of the ternary biomass composites in the molten state are influenced so much by processing sequence. This is attributed to the change of internal microstructure of these composites such as the distribution and dispersion of HF. © 2016 Author(s).JSPS, Japan Society for the Promotion of Scienc

Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: An analysis of Japan Multinational Trial Organisation LC00-03

We examined the impact of pretreatment neutrophil count on survival in patients with advanced non-small-cell lung cancer (NSCLC). A total of 388 chemo-naive patients with stage IIIB or IV NSCLC from a randomised controlled trial were evaluated. The effects of pretreatment peripheral blood neutrophil, lymphocyte and monocyte counts and neutrophil-lymphocyte ratio on survival were examined using the proportional hazards regression model to estimate hazard ratios after adjustment for covariates. The optimal cut-off value was determined by proportional hazards regression analysis with the minimum P-value approach and shrinkage procedure. After adjustment for prognostic factors, the pretreatment elevated neutrophil count was statistically significantly associated with short overall (P = 0.0008) and progression-free survival (P = 0.024), whereas no association was found between prognosis and lymphocyte or monocyte count. The cut-off value selected for neutrophil count was 4500 mm-3 (corrected hazard ratio, 1.67; 95% confidence interval (CI), 1.09-2.54). The median survival time was 19.3 months (95%CI, 16.5-21.4) for the low-neutrophil group (≥4500 mm-3, n = 204) and was 10.2 months (95%CI, 8.0-12.3) for the high-neutrophil group (≥4500 mm-3, n = 184). We confirmed that pretreatment elevated neutrophil count is an independent prognostic factor in patients with advanced NSCLC receiving modern chemotherapy. Neutrophil count is easily measured at low cost, and it may be a useful indicator of patient prognosis

Bortezomib-cyclophosphamide-dexamethasone induction/consolidation and bortezomib maintenance for transplant-eligible newly diagnosed multiple myeloma: phase 2 multicenter trial

[Objectives:] We conducted a phase II trial to prospectively evaluate the efficacy and safety of bortezomib-cyclophosphamide-dexamethasone (VCD) induction, autologous stem cell transplantation (ASCT), VCD consolidation, and bortezomib maintenance in transplant-eligible newly diagnosed multiple myeloma (NDMM) patients in Japan (UMIN000010542). [Methods:] From 2013 to 2016, 42 patients with a median age of 58 (range 42–65) years with NDMM were enrolled in 15 centers. The primary endpoint was the complete response (CR) /stringent CR (sCR) rate after transplantation, and overall/progression-free survival rates were also evaluated. [Results:] Following induction therapy, the overall response rate was obtained in 71% of patients, including a CR/sCR of 10% and a very good partial response (VGPR) of 26%. Twenty-six of the 42 patients completed ASCT following the protocol and CR/sCR and VGPR rate 100 days after ASCT was 26% and 17%, respectively. During consolidation therapy, 3 of the 24 patients achieved deeper responses. Eight of the 18 patients completed 2-year bortezomib maintenance without disease progression and grade 3/4 toxicities. Five patients were VGPR or partial response after ASCT but maintained response with 2-year bortezomib maintenance. Two-year overall and progression-free survival rates were 92.5% (95% confidence interval [CI]: 78.5%−97.5%) and 62.6% (95% CI: 45.8%−75.5%), respectively. Grade 3/4 toxicities (≥ 10%) included neutropenia (19%) and anemia (17%) in induction, and thrombocytopenia (29%) in consolidation. [Conclusion:] VCD induction/consolidation and bortezomib maintenance with ASCT for NDMM resulted in a high CR/sCR rate and provided good overall/progression-free survival in Japan

Indication and benefit of upfront hematopoietic stem cell transplantation for T-cell lymphoblastic lymphoma in the era of ALL-type induction therapies

Since the introduction of leukemia-type induction therapies for T-cell lymphoblastic lymphoma (T-LBL), improvements in the long-term outcomes of T-LBL have been reported. However, indications for and the appropriate timing of hematopoietic stem cell transplantation (HSCT) have not yet been established. Therefore, we performed a multicenter retrospective cohort study of patients with T-LBL treated using leukemia-type initial therapies to compare the outcomes after HSCT at different disease stages. We enrolled 21 patients with T-LBL from a total of 11 centers, and all patients received hyper-CVAD as a leukemia-type initial regimen. HSCT was performed during the CR1/PR1 (standard disease) stage in 11 patients, while it was completed at a later or non-remission (advanced disease) stage in 10 patients. Following HSCT, the overall survival rate was significantly greater in standard disease than in advanced-disease patients (79.5% vs. 30.0% at 5 years; hazard ratio (HR) 5.97; p = 0.03), with trend to the lower incidence of relapse in the former group (27.3% vs. 60.0% at 5 years; HR 2.29; p = 0.19). A prognostic difference was not detected between cases treated with allogeneic and autologous HSCTs. Our study suggests that frontline HSCT may be a feasible treatment option for T-LBL, even in the era of leukemia-type initial therapy

Amplified EPOR/JAK2 Genes Define a Unique Subtype of Acute Erythroid Leukemia

ゲノム解析から急性赤白血病の変異プロファイルと治療標的を解明 --特定の遺伝子変異群の組み合わせと、特徴となる遺伝子の増幅が鍵--. 京都大学プレスリリース. 2022-08-05.Acute erythroid leukemia (AEL) is a unique subtype of acute myeloid leukemia characterized by prominent erythroid proliferation whose molecular basis is poorly understood. To elucidate the underlying mechanism of erythroid proliferation, we analyzed 121 AEL using whole-genome/exome and/or targeted-capture sequencing, together with transcriptome analysis of 21 AEL samples. Combining publicly available sequencing data, we found a high frequency of gains/amplifications involving EPOR/JAK2 in TP53-mutated cases, particularly those having >80% erythroblasts designated as pure erythroid leukemia (10/13). These cases were frequently accompanied by gains/amplifications of ERG/ETS2 and associated with a very poor prognosis, even compared with other TP53-mutated AEL. In addition to activation of the STAT5 pathway, a common feature across all AEL cases, these AEL cases exhibited enhanced cell proliferation and heme metabolism and often showed high sensitivity to ruxolitinib in vitro and in xenograft models, highlighting a potential role of JAK2 inhibition in therapeutics of AEL

A postoperative left ventricular-right atrial shunt due to infectious endocarditis after aortic repair with aortic valve replacement detected by transesophageal echocardiography

Abstract Infectious endocarditis (IE) with acute heart failure is a medical emergency. In particular, postoperative IE after aortic repair with an artificial vascular graft is a life-threatening matter. We present a case in which a mobile abscess appeared on the aortic valve annulus with an intra-cardiac shunt in the left ventricle (LV) to the right atrium (RA) after ascending aortic repair with aortic valve replacement (AVR) for acute type A aortic dissection. It was diagnosed with transesophageal echocardiography (TEE), which prompted further exploration