Non-thermal Gravitino Dark Matter in Gauge Mediation

We show that gravitinos produced by decays of a supersymmetry breaking scalar field (the pseudo-moduli field) can naturally explain the observed abundance of dark matter in a certain class of the gauge mediation models. We study the decay processes as well as cosmological constraints on this scenario in detail, particularly focusing on different behavior of the real and imaginary components of the pseudo-moduli field. Cosmologically viable scenario emerges when the gravitino and the pseudo-moduli masses are O(10-100) MeV and O(100) GeV, respectively.Comment: 32 pages, 10 figure

サリチル酸誘発耳鳴に対する牛車腎気丸の抑制効果の行動学的および免疫組織化学的な根拠

Many people are affected by tinnitus, a sensation of ringing in the ear despite the absence of external sound. Goshajinkigan (GJG) is one of the formulations of Japanese traditional herbal medicine and is prescribed for the palliative treatment of patients with tinnitus. Although GJG is clinically effective in these patients, its behavioral effects and the underlying neuroanatomical substrate have not been modeled in animals. We modeled tinnitus using salicylate-treated rats, demonstrated the effectiveness of GJG on tinnitus, and examined the underlying neuronal substrate with c-Fos expression. Intraperitoneal injection of sodium salicylate (400 mg/kg) into rats for three consecutive days significantly increased false positive scores, which were used to assess tinnitus behavior. When GJG was orally administered one hour after each salicylate injection, the increase in tinnitus behavior was suppressed. The analysis of c-Fos expression in auditory-related brain areas revealed that GJG significantly reduced the salicylate-induced increase in the number of c-Fos-expressing cells in the auditory cortices, inferior colliculus, and dorsal cochlear nucleus. These results suggest a suppressive effect of GJG on salicylate-induced tinnitus in animal models.博士（医学）・甲第851号・令和4年9月28日Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)

Search for Lepton Flavor Violation in the Higgs Boson Decay at a Linear Collider

We discuss possibility of direct search for lepton flavor violation (LFV) in Yukawa interaction by measuring the branching ratio for the decay of the lightest Higgs boson ($h^0$) into a $\tau$-$\mu$ pair at a linear collider. We study the significance of the signal process, $e^+e^- \to Z^\ast \to Z h^0 \to Z \tau^\pm \mu^\mp$, against the backgrounds such as $e^{+}e^{-} \to Z \tau^{+}\tau^{-} \to Z \tau^{\pm}\mu^{\mp}+$ missings. After taking appropriate kinematic cuts, the number of the background event is considerably reduced, so that the signal can be visible when the branching ratio of $h^0 \to \tau^\pm \mu^\mp$ is larger than about $10^{-4}$. In a Minimal Supersymmetric Standard Model scenario, the effective coupling of $h^0 \tau^\pm \mu^\mp$ can be generated at loop level due to the slepton mixing. When supersymmetric mass parameters are larger than TeV scales, the branching ratio can be as large as several times $10^{-4}$. Therefore, the signal can be marginally visible at a LC. In the general two Higgs doublet model, the possible maximal value for the branching ratio of $h^0 \to \tau^\pm \mu^\mp$ can reach to a few times $10^{-3}$ within the available experimental bound, so that we can obtain larger significance.Comment: 14 pages 3 figures, REVTEX4, version accepted for publication in Physics Letters

Dynamical Solution to Supersymmetric CP Problem with Vanishing B Parameter

The CP violation gives rise to severe restriction of soft breaking terms in supersymmetric standard models. Among them, constraints on the holomorphic soft mass of Higgs doublets (the B parameter) are difficult to satisfy due to the other inherent problem in the Higgs potential; the mu problem. In this letter, it is argued that these CP and mu problems can be rather relaxed provided that B is vanishing at high-energy scale. A generic mechanism and some examples of model are presented to dynamically realize this condition by introducing gauge singlet fields.Comment: 13 pages, a comment adde

NMSSM in gauge-mediated SUSY breaking without domain wall problem

A problem of the gauge-mediated SUSY breaking model is its difficulty to generate a natural value of mu/Bmu, while the NMSSM is a natural framework to solve the mu/Bmu problem. The NMSSM in gauge-mediated SUSY breaking in its original form does not work well since the singlet field cannot develop a desired vacuum expectation value. It also suffers from the cosmological domain wall problem. We study an extension of the model to include additional vector-like matter, which is charged under the hidden QCD. It is shown that this simple extension solves both the problems. We study phenomenological and cosmological implications of this extended models. The lightest Higgs mass can be as large as 130-140 GeV for some model points.Comment: 15 pages; the version to be published in PL

Stau Kinks at the LHC

The kink signature of charged tracks is predicted in some SUSY models, and it is very characteristic signal at collider experiments. We study the kink signature at LHC using two models, SUSY models with a gravitino LSP and a stau NLSP, and R-parity violating SUSY models with a stau (N)LSP. We find that a large number of kink events can be discovered in a wide range of the SUSY parameters, when the decay length is O(10-10^5)mm. Model discrimination by identifying the daughter particles of the kink tracks is also discussed.Comment: 19 pages, 4 figures; Version published in JHEP; abstract refined, reference added and several minor corrections in tex

Impact of glycemic control with sitagliptin on the 2‑year progression of arterial stiffness : a sub‑analysis of the PROLOGUE study

Background: No conclusive evidence has been obtained yet on the significance of the effects of dipeptidyl peptidase-4 (DPP-4 inhibitor) treatment on the arterial stiffness in clinical settings. In addition, the effects of good glycemic control on the arterial stiffness have also not been clarified yet. As a sub-analysis of the PROLOGUE study, we examined the effect of a DPP-4 inhibitor (sitagliptin) on the 2-year progression of the arterial stiffness and also to determine the effect of good glycemic control on the rate of progression of the arterial stiffness. Methods: In the PROLOGUE study, the study participants were either allocated to add-on sitagliptin treatment or to continued treatment with conventional anti-diabetic agents. Among the 463 participants of the PROLOGUE study, we succeeded in measuring the brachial-ankle pulse wave velocity (baPWV) at least two times during the 2-year study period in 96 subjects. Results: The changes in the baPWV during the study period were similar between the both groups (i.e., with/without staglipitin), overall. On the other hand, when the study subjects were divided into two groups according to the glycemic control status during the study period {good glycemic control group (GC) = hemoglobin (Hb)A1c <7.0 at both 12 and 24 months after the treatment randomization; poor glycemic control group (PC) = HbA1c ≥7.0 at either 12 months, 24 months, or both}, the 2-year increase of the baPWV was marginally significantly larger in the PC group (144 ± 235 cm/s) as compared to that the GC group (−10 ± 282 cm/s) (p = 0.036). Conclusion: While the present study could not confirm the beneficial effect of sitagliptin per se on the arterial stiffness, the results suggested that good glycemic control appears to be beneficial for delaying the annual progression of the arterial stiffness

Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow

骨髄のNK細胞の分化に造血細胞が産生するIL-15が必須である --2種類の局在を示すNK細胞の新規分化モデル--. 京都大学プレスリリース. 2023-09-20.Natural killer (NK) cells are innate immune cells critical for protective immune responses against infection and cancer. Although NK cells differentiate in the bone marrow (BM) in an interleukin-15 (IL-15)-dependent manner, the cellular source of IL-15 remains elusive. Using NK cell reporter mice, we show that NK cells are localized in the BM in scattered and clustered manners. NK cell clusters overlap with monocyte and dendritic cell accumulations, whereas scattered NK cells require CXCR4 signaling. Using cell-specific IL-15-deficient mice, we show that hematopoietic cells, but not stromal cells, support NK cell development in the BM through IL-15. In particular, IL-15 produced by monocytes and dendritic cells appears to contribute to NK cell development. These results demonstrate that hematopoietic cells are the IL-15 niche for NK cell development in the BM and that BM NK cells are present in scattered and clustered compartments by different mechanisms, suggesting their distinct functions in the immune response

Probing High Reheating Temperature Scenarios at the LHC with Long-Lived Staus

We investigate the possibility of probing high reheating temperature scenarios at the LHC, in supersymmetric models where the gravitino is the lightest supersymmetric particle, and the stau is the next-to-lightest supersymmetric particle. In such scenarios, the big-bang nucleosynthesis and the gravitino abundance give a severe upper bound on the gluino mass. We find that, if the reheating temperature is \sim 10^8 GeV or higher, the scenarios can be tested at the LHC with an integrated luminosity of O(1 fb^{-1}) at \sqrt{s}=7 TeV in most of the parameter space.Comment: 17 pages, 5 figures, minor modification

Nonanomalous Discrete R-Symmetry and Light Gravitino

We discuss nonanomalous R-symmetry in the supersymmetric grand unified theories. In particular, we explore anomaly-free solutions predicting the gravitino mass in the range of 10^{-3} eV \lsim m_{3/2} \lsim 1 TeV when the $\mu$-parameter is fixed to be $\mu \simeq 1 TeV$. In the minimal SU(5) GUT, we have shown that $\mu \simeq 1 TeV$ is obtained only if the gravitino is ultralight with mass $m_{3/2} \sim 10^{-3} eV$. If extra fields ${\bf 5}\oplus{\bf 5^*}$ or ${\bf 10}\oplus{\bf 10^*}$ are introduced, many solutions predicting m_{3/2} \gsim 10^{-3} eV are found. The R-parity is violated due to the vacuum expectation value of the superpotential, but it is controlled by the discrete R-symmetry. We find that the R-parity violating couplings are naturally suppressed much below the experimental bounds for some charge assignments. These charge assignments predict light gravitino with masses of order ${\cal O}(10^{-3} eV)$--${\cal O}(1 MeV)$. These discrete R-symmetries can be considered as solutions to the $\mu$-problem in low energy supersymmetry breaking models such as the gauge mediation.Comment: 20 pages, no figure. v2: minor corrections, references added, "Note Added" in Summary adde