トルコ・コンヤ盆地からの６０．８５ｍ柱状堆積物の層相

In 1991, a 60.85 m continuous core was collected from the Konya basin (37°45′13.3″N and 32°43′5.4″E) which is located in the western part of the Anatolian Plateau Turkey, where there ware a number of important ancient civilizations. The core sediment consists of a continuous lacustrine accumulation of homogeneous silty clay and clay with shell bands, sand streams and organic-rich accumulated layers. It also contains visible gypsum crystals suggesting the existence of dry climatic condition in the past. Three ash layers were also recognized at 7.72-7.77 m, 12.15-12.20 m and 51.5 m in depth. The preliminary radiocarbon datings of the shells collected from 6 m depth are older than 40 environmental record such as interglacial-glacial cycles occurring about every 100,000 years during the past million years. This report is a sedimentological description of the core samples form the Konya Basin

MR imaging of renal cell carcinoma: associations among signal intensity, tumor enhancement, and pathologic findings.

The purpose of this study was to compare the MR characteristics of renal cell carcinomas against histologic findings and to assess the correlations among signal intensity, tumor enhancement, and pathologic findings. Fifty-four patients (56 lesions) were examined by MR imaging and then underwent partial or radical nephrectomy. The pathologic diagnosis of all lesions was renal cell carcinoma. All MR examinations were performed as dynamic studies using the same 1.5-T scanner. MR characteristics were compared against pathologic findings after resection, and the correlations among signal intensity, tumor enhancement, and pathologic findings were then assessed. A significant correlation was observed between tumor grade and tumor enhancement, with G3 lesions tending to show little enhancement. Regardless of the histologic classification, G3 tumors were found to contain highly heterotypic cancer cells and very few vessels by histopathologic examination. No significant correlations were noted between the other MR characteristics and pathologic findings. Renal cell carcinomas showing little enhancement tend to be highly malignant lesions based on the pathologic findings. Special consideration is required for these tumors with regard to the selection of surgical intervention and follow-up observation.</p

トルコ・ケステル湖から得られた柱状堆積物の植物性残存物と脂質の炭素１４年代

In 1992, a 5 m core was recovered from Lake Kestel, which is located on the southern Mediterranean coast of Turkey. Accelerator Mass Spectrometry (AMS) radiocarbon dating and stable carbon isotope (13C/12C) analysis were made on both plant remains and lipids from the core sediments.AMS radiocarbon dates of plant remains showed that the sediment was deposited at a relatively constant rate (0.21 cm/year), suggesting a record of the environmental changes during the last 2000 years. The initial radiocarbon contents (A0) in lipids were in the range of 30-90 percent modern carbon (pMC) and tend to vary inversely as 13C/12C change in lipids. Such a low content of A0 in lipids was introduced by an influx of lipids with less 14C contents from the surrounding soil. Therefore, the A0 in surrounding soil to the lake sediment in the past, possibly relating to hydrological and environmental changes such as precipitation and evaporation

Isothiazoles and Disease-Controlling Agent

PROBLEM TO BE SOLVED: To provide new compounds exhibiting high effect as a plant-controlling agent and having higher safety. SOLUTION: The present invention relates to isothiazoles represented by formula (I) [wherein A is an alkylene which may be substituted by a cycloalkyl, or a cycloalkylidene; R is a phenyl which may be substituted (wherein substituent groups are 1 to 5 groups selected from a group consisting of a halogen, an alkyl, an alkenylene, an alkoxy, a phenoxy, an alkylthio, a haloalkyl, a haloalkoxy, a haloalkylthio, phenyl and nitro)]

Bevacizumab terminates homeobox B9-induced tumor proliferation by silencing microenvironmental communication

Background: Homeobox B9 (HOXB9), a transcriptional factor, regulates developmental processes and tumor progression and has recently been recognized as one of important transcriptional factors related to angiogenesis. This study aimed to investigate the role of HOXB9 in tumorigenesis and angiogenesis. Methods: We examined the expression of HOXB9 in colorectal cancer using qPCR and in situ hybridization. We also examined the effect of HOXB9 overexpression in colorectal cancer using a proliferation assay, ELISA, a multiplex assay, and xenograft models. The clinical significance of HOXB9 was statistically evaluated in resected specimens. Results: HOXB9 was expressed in colorectal cancer specimens. HOXB9 induced angiogenesis and tumor proliferation in vitro, which resulted in high tumorigenicity in vivo and poor overall survival. Bevacizumab, an anti-vascular endothelial growth factor (VEGF) antibody, remarkably suppressed tumor proliferation by inhibiting angiogenesis in HOXB9-overexpressing xenografts, and it improved overall survival and provided prolonged progression-free survival in HOXB9-overexpressing patients. A comprehensive multiplex assay of the supernatant of cancer cells co-cultured with human vascular endothelial cells and fibroblasts indicated significantly higher interleukin-6 (IL6) levels than those in the supernatant of monocultured cells. HOXB9 overexpression in clinical specimens was significantly correlated with increased IL6 expression. An IL6-neutralizing antibody inhibited VEGF secretion and tumor proliferation in the co-culture system. Conclusions: HOXB9 promotes the secretion of angiogenic factors, including VEGF, to induce tumor proliferation through microenvironmental production of cytokines including IL6 signaling. Moreover, silencing of VEGF or IL6 terminates cytokine release in tumor microenvironment. Thus, HOXB9 and IL6 may be potential biomarkers for bevacizumab treatment