On the Nonlinear Impulsive Ψ\Psi--Hilfer Fractional Differential Equations

In this paper, we consider the nonlinear $\Psi$-Hilfer impulsive fractional differential equation. Our main objective is to derive the formula for the solution and examine the existence and uniqueness of results. The acquired results are extended to the nonlocal $\Psi$-Hilfer impulsive fractional differential equation. We gave an applications to the outcomes we procured. Further, examples are provided in support of the results we got.Comment: 2

Vortex dynamics of rotating dipolar Bose-Einstein condensates

We study the influence of dipole-dipole interaction on the formation of vortices in a rotating dipolar Bose-Einstein condensate (BEC) of $^{52}$Cr and $^{164}$Dy atoms in quasi two-dimensional geometry. By numerically solving the corresponding time-dependent mean-field Gross-Pitaevskii equation, we show that the dipolar interaction enhances the number of vortices while a repulsive contact interaction increases the stability of the vortices. Further, an ordered vortex lattice of relatively large number of vortices is found in a strongly dipolar BEC.Comment: 15 pages, 10 figures, 1 tabl

Infectivity of nematode parasites of the common toad, Duttaphrynus melanostictus (Schneider, 1799) Frost et al., 2006 (Anura: Bufonidae) from different localities of Aurangabad

The common toad, Duttaphrynus melanostictus, Schneider, 1799) Frost et al., 2006 from Aurangabad was found to harbor three species of nematodes; Oswaldocruzia goezei (Skrjabin and Schulz, 1952), Trichuris globusa (V. Linstow, 1901, Ransom, 1911), Oxysomatium macintoshii (Karve, 1927). Among all the parasites, Trichuris globulosa represents the accidental new host record for D. melanostictus in Maharashtra

An Advanced LMI-Based-LQR Design for Load Frequency Control of an Autonomous Hybrid Generation System

Part 13: Energy GenerationInternational audienceThis paper proposes a load frequency control scheme for an autonomous hybrid generation system consisting of wind turbine generator (WTG), diesel engine generator (DEG), fuel cell (FC), aquaelectrolyzer (AE) and battery energy storage system (BESS). In wind power generation systems, operating conditions are changing continually due to wind speed and load changes, having an effect on system frequency. Therefore, a robust controller is required for load frequency control. The control scheme is based on Linear Matrix Inequality (LMI)-Linear Quadratic Regulator (LQR). The control optimization problem is obtained in terms of a system of LMI constraints and matrix equations that are simultaneously solved. The proposed load frequency control scheme with the advanced LMI-based-LQR (ALQR) design is applied for the autonomous hybrid generation system. The effectiveness and robustness of the proposed controller is demonstrated for different load and wind power perturbations. The results suggest superior performance of the proposed ALQR controller against an optimal output state feedback controller. The integrated control could be realized though the web by applying Internet of Things technologies within the future smart grid

Inhibitory effect of calotropis gigantea extract on ovalbumin-induced airway inflammation and arachidonic acid induced inflammation in a murine model of asthma

The root of Calotropis gigantea has been reported as a traditional folkloric medicine in treatment of asthma in the Indian literature. Root contain α-and β-amyrin are reported to possess anti-lipoxygenase activity. Present study was undertaken to investigate the effect of methanolic extract of root of Calotropis gigantea (Linn.) R.Br. (CG) on ovalbumin induced asthma and arachidonic acid induced paw edema in rats. In ovalbumin induced asthma, rats were sensitized and challenged with ovalbumin (OVA). The effect of CG at 100, 200, 400 mg/kg, p.o. on inflammatory cell count, level of nitric oxide and total protein in bronchalveolar lavage (BAL) fluid, lung antioxidant enzymes (LPO, GSH, SOD, Catalase) and histopathological changes were observed. Change in paw edema volume was measured in arachidonic acid induced paw edema model. CG at 200, 400 mg/kg, p.o. showed significant inhibition of eosinophil, neutrophil and lymphocyte and total leukocyte count in bronchalveolar lavage (BAL) fluid (p<0.05). In BAL fluid, CG significantly reduced the nitric oxide and total protein levels (p<0.05). CG significantly restored the levels of GSH, SOD and LPO in lungs (p<0.01). CG at doses of 200, 400 mg/kg significantly inhibited OVA induced histological changes (p<0.01). CG significantly reduced the arachidonic acid induced paw edema volume (p<0.05). These results suggest that CG may prove to be potential therapeutic drug for treating asthma owing to its anti-inflammatory, anti-lipoxygenase and antioxidant activities. \ud \u

ADENOKARCINOM JAJOVODA – PRIKAZ BOLESNICE

Mrs. UB aged 35 years came to us with complaints of oligomenorrhoea, lower abdominal pain, haematuria, retention of urine with CT scan report of December 2008 which was suggestive of left sided ovarian tumor. We investigated her with ultrasonography and CA-125 level and primary diagnosis of left sided ovarian tumor was made. On laparotomy it turned out to be primary fallopian tube carcinoma. Abdominal total hysterectomy with bilateral salpingo-oophorectomy with omental and node biopsy was done. On histopathological examination it turned out, as primary serous adenocarcinoma of fallopian tube grade G2PT1(C)PN0. To patient were given two cycles of chemotherapy. Primary fallopian tube carcinomas are quite rare. In routine practice when we come across a case, it is usually diagnosed as an adnexal mass, more commonly as an ovarian tumor. The usual investigations cannot discriminate between the ovarian and the tubal mass. The fallopian tube cancer comes as a surprise on laparotomy. We have to be ready to deal with this condition even when it suddenly crops up.Gospođa UB, životne dobi 35 godina, javila sa smetnjama oligomenoreje, bolima donjeg trbuha, hematurijom i retencijom mokraće. Posjedovala je CT nalaz iz prosinca 2008. godine koji je upućivao na lijevostrani ovarijski tumor. Istražili smo je ultrazvukom i razinom Ca 125 u krvi te je bila postavljena dijagnoza lijevostranog ovarijskog tumora. Učinjena je laparotomija te je nađen primarni karcinom lijevog jajovoda. Ućinjena je totalna abdominalna histerektomija s obostranom salpingo-ooforektomijom s biopsijom omentuma i limfnih čvorova. Histopatološki je utvrđen primarni adenokarcinom jajovoda, stupnja G2PT(1C)PN0. Bolesnici su aplicirana dva ciklusa kemoterapije. Primarni rak jajovoda je zaista rijedak. U rutinskoj praksi se dijagnosticira kao adneksalna tvorba, obično kao ovarijski tumor. Uobičajene pretrage ne mogu razlikovati ovarijsku od tubarne tvorbe. Rak tube Fallopii je iznenađenje prigodom laparotomije. Moramo biti spremni suočiti se s tim stanjem makar ono naglo iskrsne

Existence and multiplicity of solutions for fractional κ(ξ)\kappa(\xi)-Kirchhoff-type equation

In this paper, we aim to tackle the questions of existence and multiplicity of solutions to a new class of $\kappa(\xi)$-Kirchhoff-type equation utilizing a variational approach. Further, we research the results from the theory of variable exponent Sobolev spaces and from the theory of space $\psi$-fractional $\mathcal{H}^{\mu,\nu;\,\psi}_{\kappa(\xi)}(\Lambda)$. In this sense, we present a few special cases and remark on the outcomes explored.Comment: 18 page

SYNTHESIS, IN VITRO ANTIMICROBIAL ACTIVITY OF SCHIFF'S BASE, AZETIDINONES AND THIAZOLIDINONES

Objective: The objective of the present study is to synthesize 3-Chloro-4-[3-(2,4-dichloro-5-fluoro phenyl)-1H-pyrazol-4-yl]-1-(substituted) azetidin-2-one [4a-n] and 2-[3-(2,4-Dichloro-5-fluoro phenyl)-1H-pyraol-4-yl]-3-(substituted phenyl)-1,3-thiazolidin-4-one [5a-n]. The structure of all synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral studies. Methods: The titled compounds 3-Chloro-4-[3-(2,4-dichloro-5-fluoro phenyl)-1H-pyrazol-4-yl]-1-(substituted) azetidin-2-one [4a-n] and 2-[3-(2,4-Dichloro-5-fluoro phenyl)-1H-pyraol-4-yl]-3-(substituted phenyl)-1,3-thiazolidin-4-one [5a-n] were synthesized by the reaction of N-{[3-(2,4-dichloro-5-fluoro phenyl)-1H-pyraol-4-yl] methylene } substituted anilin [3a-n] with chloro acetyl chloride and thioglycolic acid respectively. Compounds N-{[3-(2,4-dichloro-5-fluoro phenyl)-1H-pyraol-4-yl] methylene} substituted aniline [3a-n] were synthesized by the reaction of 3-(2,4-dichloro-5-fluoro phenyl)-1H-pyrazol-4-carbaldehyde [2] with primary aromatic amine in alcohol. All compounds were evaluated for their antimicrobial activity.Results: Compounds 3a,3b,3d,3j,3l,4d,4e,4j,4l,4m,5e,5g,5h,5n exhibited excellent to good antibacterial activity as compared to reference drugs.Conclusion: In summary, N-{[3-(2,4-dichloro-5-fluoro phenyl)-1H-pyraol-4-yl] methylene } substituted anilin [3a-n], 3-Chloro-4-[3-(2,4-dichloro-5-fluoro phenyl)-1H-pyrazol-4-yl]-1-(substituted) azetidin-2-one [4a-n] and 2-[3-(2,4-Dichloro-5-fluoro phenyl)-1H-pyraol-4-yl]-3-(substituted phenyl)-1,3-thiazolidin-4-one [5a-n] derivatives have been synthesized and characterized. In vitro antimicrobial testing of the compounds was carried out by microdilution Method. Amongst the synthesised compounds, many of them had proven their antimicrobial potency which varies from good to excellent

Disruption of the MyoD/p21 Pathway in Rhabdomyosarcoma

Purpose. Rhabdomyosarcoma (RMS) is an embryonal tumor thought to arise from skeletal muscle cells that fail to differentiate terminally. The majority of RMSs express MyoD, a protein essential to the differentiation of skeletal muscle. It was recently shown that during myogenesis, MyoD activates the expression of the cyclin-dependent kinase inhibitor (CDKi), p21, which itself plays a critical role in normal muscle development. To investigate the integrity of the MyoD/p21 pathway in RMS, we analyzed p21 and its relationship to MyoD expression in RMS