x509-free access to WLCG resources

Access to WLCG resources is authenticated using an x509 and PKI infrastructure. Even though HEP users have always been exposed to certificates directly, the development of modern Web Applications by the LHC experiments calls for simplified authentication processes keeping the underlying software unmodified. In this work we will show a solution with the goal of providing access to WLCG resources using the user's home organisations credentials, without the need for user-acquired x509 certificates. In particular, we focus on identity providers within eduGAIN, which interconnects research and education organisations worldwide, and enables the trustworthy exchange of identity-related information. eduGAIN has been integrated at CERN in the SSO infrastructure so that users can authenticate without the need of a CERN account. This solution achieves x509-free access to Grid resources with the help of two services: STS and an online CA. The STS (Security Token Service) allows credential translation from the SAML2 format used by Identity Federations to the VOMS-enabled x509 used by most of the Grid. The IOTA CA (Identifier-Only Trust Assurance Certification Authority) is responsible for the automatic issuing of short-lived x509 certificates. The IOTA CA deployed at CERN has been accepted by EUGridPMA as the CERN LCG IOTA CA, included in the IGTF trust anchor distribution and installed by the sites in WLCG. We will also describe the first pilot projects which are integrating the solution.Peer reviewe

A Mathematical Model of the Immune and Neuroendocrine Systems Mutual Regulation under the Technogenic Chemical Factors Impact

The concept of the triad regulatory metasystem, which includes the neuroendocrine and immune regulation systems, is currently generally accepted. Changes occurring in each of the regulatory systems in response to the impact of technogenic chemical factors are also well known. This paper presents mathematical models of the immune and neuroendocrine system functioning, using the interaction between these systems in response to bacterial invasion as an example, and changes in their performance under exposure to chemical factors, taking into account the stage of functional disorders in a producing organ, using the performance of the bone marrow as an example

PROSPECTS FOR CREATION OF ULTRA-SUPERCRITICAL STEAM PARAMETERS POWER UNITS IN RUSSIA AND IN THE WORLD

The article discusses the prospects for the development of power units for ultra-supercritical steam parameters, analyzes their advantages and limitations, and examines the current state of the development in Russia.В статье рассматриваются перспективы разработок энергоблоков на ультрасверхкритические параметры пара, анализируются их преимущества и ограничения, рассматривается текущее состояние разработок в России

Scientific Data Lake for High Luminosity LHC project and other data-intensive particle and astro-particle physics experiments

Indexación ScopusThe next phase of LHC Operations-High Luminosity LHC (HL-LHC), which is aimed at ten-fold increase in the luminosity of proton-proton collisions at the energy of 14 TeV, is expected to start operation in 2027-2028 and will deliver an unprecedented scientific data volume of multi-exabyte scale. This amount of data has to be stored and the corresponding storage system should ensure fast and reliable data delivery for processing by scientific groups distributed all over the world. The present LHC computing and data processing model will not be able to provide the required infrastructure growth even taking into account the expected hardware technology evolution. To address this challenge the new state-of-The-Art computing infrastructure technologies are now being developed and are presented here. The possibilities of application of the HL-LHC distributed data handling technique for other particle and astro-particle physics experiments dealing with large-scale data volumes like DUNE, LSST, Belle-II, JUNO, SKAO etc. are also discussed. © Published under licence by IOP Publishing Ltd.https://iopscience-iop-org.recursosbiblioteca.unab.cl/article/10.1088/1742-6596/1690/1/01216

Numerical Modeling and Validation of the CFD Model of Bubble Column Hydrodynamics for CO2 Mineralization

The CFD-model of a bubble column (water-air) was validated using published experimental data obtained on a cylindrical installation. The results of the validation showed the satisfactory applicability of the model for engineering calculations

Alcohol increases circulatory disease mortality in Russia: acute and chronic effects or misattribution of cause?

Background There is a consensus that the large fluctuations in mortality seen in Russia in the past two decades can be attributed to trends in alcohol consumption. However, the precise mechanisms linking alcohol to mortality from circulatory disease remain unclear. It has recently been argued that a substantial number of such deaths currently ascribed to cardiovascular disorders are misclassified cases of acute alcohol poisoning

Pathological aspects of the maternal mortality

The article deals with the problem of maternal mortality. The most common causes and mechanisms of maternal mortality are analyzed. The role of treating physicians in eliminating the first symptoms of the causes of maternal mortality has been identified and substantiated.В статье рассмотрена проблема материнской смертности. Проанализированы наиболее частые причины и механизмы материнской смертности. Выявлена и обоснована роль лечащих врачей в устранении первых симптомов причин, вызывающих материнскую смертность

Manageable noninfectious pathology risk factors analysis in Perm region

Research aim is presentation of methodological approaches system for noninfectious pathology risk analysis tested in Perm region. Noninfectious pathology risk analysis in Perm region includes non-cancerogenic risk quantitative assessment based on epidemiological studies, choice of effective noninfectious pathology risk reduction strategy by means of Rospotrebnadzor and primary health care. Strategy search contains noninfectious pathology preventability estimation by comparative and expert assessment resulted to health changes reserves identification; its manageability estimation by risk factors analysis, management parameters, simulation modeling, optimization goals decision, strategy and management quality assessment Estimation of Perm region Rospotrebnadzor management activity revealed that risk indicators applying and economical assessment of risk unit value allow predicting management effects and estimating its efficiency using life expectancy increase criterion.Цель работы - представление системы методических подходов к анализу риска неинфекционной патологии, апробированных в Пермском крае. Представлены основные блоки анализа риска неинфекционной патологии в Пермском крае включая количественную оценку неканцерогенного риска на основании эпидемиологических исследований, выбор эффективных стратегий снижения риска неинфекционной патологии средствами системы Роспотребнадзора и первичной медико-санитарной помощи. Алгоритм поиска таких стратегий включает оценку предотвратимости неинфекционной патологии методами сравнительных и экспертных оценок, в результате которых определяются резервы направленных изменений здоровья, ее управляемости при помощи анализа факторов риска, параметров управления, имитационного моделирования, решения оптимизационных задач, оценки стратегии и качества управления. Оценка управляющих действий Роспотребнадзора по Пермскому краю показала, что использование показателей риска и оценка стоимости единицы риска нарушений здоровья позволяет не только прогнозировать эффект управляющих действий, но и оценивать их эффективность с использованием критерия увеличения ожидаемой продолжительности жизни

Identifying the determinants of premature mortality in Russia: overcoming a methodological challenge

<p>Abstract</p> <p>Background</p> <p>It is thought that excessive alcohol consumption is related to the high mortality among working age men in Russia. Moreover it has been suggested that alcohol is a key proximate driver of the very sharp fluctuations in mortality seen in this group since the mid-1980s. Designing an individual-level study suitable to address the potential acute effects of alcohol consumption on mortality in Russia has posed a challenge to epidemiologists, especially because of the need to identify factors that could underlie the rapid changes up and down in mortality rates that have been such a distinctive feature of the Russian mortality crisis. In order to address this study question which focuses on exposures acting shortly before sudden death, a cohort would be unfeasibly large and would suffer from recruitment bias.</p> <p>Methods</p> <p>Although the situation in Russia is unusual, with a very high death rate characterised by many sudden and apparently unexpected deaths in young men, the methodological problem is common to research on any cause of death where many deaths are sudden.</p> <p>Results</p> <p>We describe the development of an innovative approach that has overcome some of these challenges: a case-control study employing proxy informants and external data sources to collect information about proximate determinants of mortality.</p> <p>Conclusion</p> <p>This offers a set of principles that can be adopted by epidemiologists studying sudden and unexpected deaths in other settings.</p

Анализ структурно-функциональной организации хлоропластного генома карельской березы на основании данных высокопроизводительного секвенирования

The sequencing and annotation of the curly birch chloroplast genome were carried out. A high level of similarity of the structural and functional organization of cpDNA among the species of the Betulaceae family was revealed. A set of primers was developed to assess the level of expression of EST markers of the curly birch cpDNA by the real time PCR method.Проведено секвенирование и аннотация хлоропластного генома карельской березы. Выявлен высокий уровень сходства структурно-функциональной организации хпДНК среди видов семейства Betulaceae. Разработан набор праймеров для оценки уровня экспрессии EST-маркеров хпДНК карельской березы методом ПЦР-РВ