Renal Evaluation in Women with Preeclampsia

Background/Aims: Preeclampsia (PE) is a cause of glomerulopathy worldwide. Urinary retinol-binding protein (RBP) is a marker of proximal tubular dysfunction, albuminuria is an endothelial injury marker, urine protein:creatinine ratio (PCR) may have a predictive value for renal disease later in life, and, recently, podocyturia has been proposed as a sensitive tool in pregnancy, but it needs to be tested. The aim of this study was to evaluate renal involvement in PE and healthy pregnancy. Methods: Case-control study with 39 pregnant women assessed after 20 weeks of gestation (25 in the control group, CG, and 14 in the PE group) by performing urinary tests. Results: Mean (±SD) age and gestational age of the CG were 26.9 ± 6.4 years and 37.1 ± 5.0 weeks, and of the PE group 26.4 ± 6.9 years and 30.6 ± 5.6 weeks, respectively (p = 0.001). Mean (±SD) urinary RBP (p = 0.017), albuminuria (p = 0.002), and urinary albumin concentration (UAC) ratio (p = 0.006) of the CG were 0.4 ± 0.7 mg/l, 7.3 ± 6.9 mg/l, and 8.2 ± 6.7 mg/g and of the PE group 2.0 ± 4.4 mg/l, 2,267.4 ± 2,130.8 mg/l (p = 0.002), and 3,778.9 ± 4,296.6 mg/g (p = 0.006), respectively. Mean (±SD) urine PCR in the PE group was 6.7 ± 6.1 g/g (p Conclusions: Urinary RBP, PCR, albuminuria, and UAC ratio were elevated in the PE group in comparison to the CG. Podocyturia did not predict PE

Dia Mundial do Rim 2011 Proteinúria e creatinina sérica: testes essenciais para diagnóstico de doença renal crônica

Universidade Federal de São Paulo (UNIFESP)UNIFESP Ambulatório de GlomerulopatiasSociedade Brasileira de Nefrologia Comitê de Prevenção de Doença Renal CrônicaUniversidade Federal de Juiz de Fora Faculdade de MedicinaUFJF Núcleo Interdisciplinar de Estudos, Pesquisas e Tratamento em NefrologiaFundação Instituto Mineiro de Estudos e Pesquisas em NefrologiaUNIFESP, Ambulatório de GlomerulopatiasSciEL

Dividing stage 3 of chronic kidney disease (CKD): 3A and 3B

Universidade Federal de São Paulo, Div Nephrol, Dept Med, BR-04023900 São Paulo, BrazilComm Kidney Dis Prevent Previna Se Campaign, Brazilian Soc Nephrol, São Paulo, BrazilRio de Janeiro State Univ UERJ, Dept Internal Med, Rio de Janeiro, BrazilUFJF, Dept Internal Med, Juiz de Fora, MG, BrazilUniversidade Federal de São Paulo, Div Nephrol, Dept Med, BR-04023900 São Paulo, BrazilWeb of Scienc

Strategies of the Brazilian Chronic Kidney Disease Prevention Campaign (2003–2009)

In Brazil, as in the rest of the world, the prevalence of chronic kidney disease (CKD) is increasing. In order to alert the population, health professionals and authorities to this risk, in 2003, the Brazilian Society of Nephrology launched a CKD prevention campaign called ‘Previna-se’. In addition, since its onset, Brazil has participated in the World Kidney Day efforts and has developed several prevention strategies. Here, we summarize the main strategies adopted in this campaign (population screening, events and meetings, distribution of educational materials, routine report of estimated glomerular filtration rate) and our initial results, sharing practical experience that could be useful in other developing countries.</jats:p