8 research outputs found
Antiretroviral agents and HIV-1 disease : analysis of In vitro phenotypic and functional markers of zidovudine therapy
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Phorbol myristoyl acetate- and endotoxin-stimulated generation of intracellular superoxide in human monocytes during endotoxaemia
No full textSecondâmessenger pathways involved in the regulation of survival in germinalâcentre B cells and in burkitt lymphoma lines
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Inhibition of ICE-family cysteine proteases rescues murine lymphocytes from lipoxygenase inhibitor-induced apoptosis
Get PDFTwo lipophilic derivatives of caffein acid which inhibit lipoxygenase, caffeic acid phenethyl ester (CAPE) and N,N'- dicyclohexyl-O-(3,4-dihydroxycinnamoyl)-isourea (DCHCU), reduced the proliferative response of murine splenocytes to concanavalin A in vitro. Both CAPE and DCHCU induced apoptosis in murine thymocyte cultures as verified by flow cytometry and by visualisation of DNA with acridine orange staining. CAPE-induced apoptosis was inhibited by z-VAD-fmk, an inhibitor of the interleukin-l[~-converting enzyme family of cysteine proteases. We suggest that the lipoxygenase pathway of arachidonic acid metabolism plays a role in regulating lympho- cyte responses such as proliferation and apoptosis
Inhibition of ICE-family cysteine proteases rescues murine lymphocytes from lipoxygenase inhibitor-induced apoptosis
No full textLY294002-Mediated Inhibition of Phosphatidylinositol 3-Kinase Activity Triggers Growth Inhibition and Apoptosis in CD40-Triggered RamosâBurkitt Lymphoma B Cells
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