ECRH deposition profile in ASDEX Upgrade

The ASDEX Upgrade ECRH systemis designed for very narrow power deposition. We describe different attempts to verify the deposition profile: from switch-on/off events, from modulated heating, and from simulations of pulses

Electron heat transport in ASDEX Upgrade: experiment and modelling

The electron heat transport is investigated in ASDEX Upgrade using electron cyclotron heating (ECH) combining steady-state and power modulation schemes. Experiments in which the electron heat flux has been varied in the confinement region while the edge was kept constant were performed. They demonstrate that Te and Te/Te can be varied by a factor of 3 and 2, respectively. They allow a detailed determination of the transport characteristics by comparing steady-state and modulation data with modelling. The analyses clearly show the existence of a threshold ( Te/Te)crit above which transport increases. Both steady-state and modulation experiments agree with such a transport model. The experiments have been carried out at low density in the L-mode to ensure low electron–ion coupling and good conditions for studying electron heat transport. The experiments were carried out at two different values of plasma current and show that transport increases at low current, as well-known from global scaling laws for confinement time. In the pure off-axis cases the region inside the ECH deposition is just at the ( Te/Te)crit threshold, which allows it to be measured directly from the profile of Te/Te deduced from the experimental Te profile. Using this technique, it appears that the turbulence threshold agrees with that expected from the trapped electron mode driven turbulence. It has the correct absolute value and seems to have the correct radial dependence that is determined by the trapped electron fraction and by the density gradient. It almost does not vary with other plasma parameters. In contrast, the threshold calculated for electron temperature gradient modes is higher than the experimental values of Te/Te and this turbulence is therefore not expected to be excited under these experimental conditions

Copy number variation in bipolar disorder.

Large (>100 kb), rare (500 kb) CNVs in BD compared with SZ, most notably for deletions >1 Mb (P=9 × 10(-4))

Schizophrenia copy number variants and associative learning

Large-scale genomic studies have made major progress in identifying genetic risk variants for schizophrenia. A key finding from these studies is that there is an increased burden of genomic copy number variants (CNVs) in schizophrenia cases compared with controls. The mechanism through which these CNVs confer risk for the symptoms of schizophrenia, however, remains unclear. One possibility is that schizophrenia risk CNVs impact basic associative learning processes, abnormalities of which have long been associated with the disorder. To investigate whether genes in schizophrenia CNVs impact on specific phases of associative learning we combined human genetics with experimental gene expression studies in animals. In a sample of 11 917 schizophrenia cases and 16 416 controls, we investigated whether CNVs from patients with schizophrenia are enriched for genes expressed during the consolidation, retrieval or extinction of associative memories. We show that CNVs from cases are enriched for genes expressed during fear extinction in the hippocampus, but not genes expressed following consolidation or retrieval. These results suggest that CNVs act to impair inhibitory learning in schizophrenia, potentially contributing to the development of core symptoms of the disorder

The contribution of genetic variants to disease depends on the ruler

Our understanding of the genetic basis of disease has evolved from descriptions of overall heritability or familiality to the identification of large numbers of risk loci. One can quantify the impact of such loci on disease using a plethora of measures, which can guide future research decisions. However, different measures can attribute varying degrees of importance to a variant. In this Analysis, we consider and contrast the most commonly used measures-specifically, the heritability of disease liability, approximate heritability, sibling recurrence risk, overall genetic variance using a logarithmic relative risk scale, the area under the receiver-operating curve for risk prediction and the population attributable fraction-and give guidelines for their use that should be explicitly considered when assessing the contribution of genetic variants to disease

Advances in ab-initio theory of Multiferroics. Materials and mechanisms: modelling and understanding

Within the broad class of multiferroics (compounds showing a coexistence of magnetism and ferroelectricity), we focus on the subclass of "improper electronic ferroelectrics", i.e. correlated materials where electronic degrees of freedom (such as spin, charge or orbital) drive ferroelectricity. In particular, in spin-induced ferroelectrics, there is not only a {\em coexistence} of the two intriguing magnetic and dipolar orders; rather, there is such an intimate link that one drives the other, suggesting a giant magnetoelectric coupling. Via first-principles approaches based on density functional theory, we review the microscopic mechanisms at the basis of multiferroicity in several compounds, ranging from transition metal oxides to organic multiferroics (MFs) to organic-inorganic hybrids (i.e. metal-organic frameworks, MOFs)Comment: 22 pages, 9 figure