Large (>100 kb), rare (500 kb) CNVs in BD compared with SZ, most notably for deletions >1 Mb (P=9 × 10(-4))

A McQuillin

Cross-Disorder Group of the Psychiatric Genomics Consortium

D Grozeva

D Malhotra

D Zhang

E K Green

E Rees

EK Green

F Degenhardt

G Genovese

G Kirov

I Jones

J L Moran

J T R Walters

JI Nurnberger Jr

JK Wing

K D Chambert

K-G Smith

L Forty

L Georgieva

L Jones

L Priebe

M C O'Donovan

M J Owen

MJ Owen

ML Hamshere

N Craddock

NM Williams

P Sklar

RL Spitzer

RM Murray

S A McCarroll

S Girirajan

S Purcell

S Ripke

S Steinberg

Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium

Schizophrenia Working Group of the Psychiatric Genomics Consortium

SE Bergen

SE McCarthy

SM Purcell

PubMed

Large (>100 kb), rare (500 kb) CNVs in BD compared with SZ, most notably for deletions >1 Mb (P = 9 × 10−4).Version of Recor

Green, EK

Rees, E

Walters, JTR

Smith, K-G

Forty, L

Grozeva, D

Moran, JL

Sklar, P

Ripke, S

Chambert, KD

Genovese, G

McCarroll, SA

Jones, I

Jones, L

Owen, MJ

O’Donovan, MC

Craddock, N

Kirov, G

Harvard University - DASH

Molecular Psychiatry

Copy number variation in bipolar disorder

Large (>100 kb), rare (500 kb) CNVs in BD compared with SZ, most notably for deletions >1 Mb (P=9 × 10-4)

Green, E.K.

Rees, E.

Walters, J.T.R.

Gordon-Smith, Katherine

Forty, L.

Grozeva, D.

Moran, J.L.

Sklar, P.

Ripke, S.

Chambert, K.D.

Genovese, G.

McCarroll, S.A.

Jones, I.

Jones, Lisa

Owen, M.J.

O'Donovan, M.C.

Craddock, N.

Kirov, G.

University of Worcester Research and Publications

Copy Number Variation in Bipolar Disorder

Large (4100 kb), rare (o1% in the population) copy number variants (CNVs) have been shown to confer risk for schizophrenia (SZ), but the findings for bipolar disorder (BD) are less clear. In a new BD sample from the United Kingdom (n = 2591), we have examined the occurrence of CNVs and compared this with previously reported samples of 6882 SZ and 8842 control subjects. When combined with previous data, we find evidence for a contribution to BD for three SZ-associated CNV loci: duplications at 1q21.1 (P = 0.022), deletions at 3q29 (P = 0.03) and duplications at 16p11.2 (P = 2.3 × 10− 4). The latter survives multiple-testing correction for the number of recurrent large CNV loci in the genome. Genes in 20 regions (total of 55 genes) were enriched for rare exonic CNVs among BD cases, but none of these survives correction for multiple testing. Finally, our data provide strong support for the hypothesis of a lesser contribution of very large (4500 kb) CNVs in BD compared with SZ, most notably for deletions 41Mb (P=9×10− 4)

Green, E. K.

Walters, J. T. R.

Moran, J. L.

Chambert, K. D.

McCarroll, S. A.

Jones, L.

Owen, M. J.

O'Donovan, M. C.

Online Research @ Cardiff

Large (>100 kb), rare (<1% in the population) copy number variants (CNVs) have been shown to confer risk for schizophrenia (SZ), but the findings for bipolar disorder (BD) are less clear. In a new BD sample from the United Kingdom (n=2591), we have examined the occurrence of CNVs and compared this with previously reported samples of 6882 SZ and 8842 control subjects. When combined with previous data, we find evidence for a contribution to BD for three SZ-associated CNV loci: duplications at 1q21.1 (P=0.022), deletions at 3q29 (P=0.03) and duplications at 16p11.2 (P=2.3 × 10-4). The latter survives multiple-testing correction for the number of recurrent large CNV loci in the genome. Genes in 20 regions (total of 55 genes) were enriched for rare exonic CNVs among BD cases, but none of these survives correction for multiple testing. Finally, our data provide strong support for the hypothesis of a lesser contribution of very large (>500 kb) CNVs in BD compared with SZ, most notably for deletions >1 Mb (P=9 × 10-4)

Name not available

Crossref

https://dash.harvard.edu/bitstream/1/29407737/1/5038134.pdf

Copy number variation in bipolar disorder.

Copy number variation in bipolar disorder.

Abstract

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Harvard University - DASH

University of Worcester Research and Publications

Online Research @ Cardiff

Name not available

Crossref