Basketball History

This article was prepared in August, 1950, by Edward R. Kirkpatrick for one of his duck dinners, but was never used. This document was presented to Illinois Wesleyan University by Mr. Charles Kirkpatrick at the special banquet honoring the basketball team of 1954 and their co-captains and the captains of preceding basketball teams back through the years. This document represents research by two brothers: Edward B. Kirkpatrick and Charles Kirkpatrick. Date April 2, 1954. Signed MJ

Non-equivalence of antibiotic generic drugs and risk for intensive care patients

Background: The underlying axiom in applying generic drugs is the equivalence of their active ingredient with the (usually more expensive) innovator product, an all-embracing statement with the insidious result that physicians assume that the generic products have been subjected to the same rigorous testing regimens as the brand-name products. The present paper presents novel experimental data on an investigator-blinded comparison between the innovator imipenem antibiotic, and a number of its generics. Methods: Particulate matter contamination of each group was visualized by means of a membrane filter method. Functional studies in an animal model–the dorsal skinfold chamber technique in mice-designed to simulate the state of microcirculatory dysfunction in intensive care patients was performed, in order to assess the influence of the particulate matter of each group on the functional capillary density of the striated skin muscle, after their intravenous injection. Results: The results showed massive particulate contamination of the generics, in a size range relevant for impacting the microcirculation. The particulate contamination contributed in some generic groups to a significant shutdown of tissue perfusion. Conclusion: The presented data underscore the need to raise the regulatory barriers for the entry of generics to the market, well beyond the simplistic proof of “bioequivalence”, which in no measure deals with the essential questions of quality and patient safety. If generics are used, they should be tested by a filter technique and optical microscopy, to ensure the absence especially of small particulate contaminants and their purity

The Bobwhite Quail of Crane Naval Ammunition Depot, Indiana - 25 Years of Protection and Plant Succession

A low-density bobwhite quail population was studied to determine its status after 25 years of plant succession ·and protection from hunting on Crane Naval Anununition Depot. The summer breeding population on the study area was approximately one-fifth of that around the periphery of CNAD. The winter population was approximately 1 bird per 50 acres. The subadult to adult ratio was normal (83: 17) but the corresponding sex ratio of 60M:40F was unbalanced. Coveys retained their identity and, with the exception of 1 covey, maintained their numbers during winter. The major habitat limitation occurred during the nesting and brooding season. The low density of bobwhites was concluded to be primarily the combined result of poor nesting cover and above-normal loss of mature females during the breeding season

The Relationship Between Active Galactic Nuclei and Metal-enriched Outflows in Galaxy Clusters

Clusters of galaxies are host to powerful Active Galactic Nuclei (AGN) that greatly affect the thermal history of clusters. By keeping X-ray emitting gas from cooling, massive, run away star formation does not occur in the brightest cluster galaxy (BCG). This is achieved through radio jets displacing large quantities of metal-rich gas and carving out cavities in the intracluster medium (ICM). This metal-rich gas was originally formed within the BCG and ejected through type Ia supernovae. The current distribution of the ejecta suggests an extra source of energy has spread the material far out into the ICM. Currently, it is unclear what mechanisms are responsible. In this thesis, I present evidence, in the form of X-ray imaging and spectra, that establishes a link between AGN and the observed distribution of metal-rich gas. First, the BCG in the Abell 1664 cluster is unusually blue and is forming stars at a rate of ~23 solar masses per year. The BCG is located within 5 kpc of the X-ray peak, where the cooling time of 3.5×10^8 yr and entropy of 10.4 keV cm^2 are consistent with other star-forming BCGs in cooling flow clusters. The cooling rate in this region is roughly consistent with the star formation rate, suggesting that the hot gas is condensing onto the BCG. We use the scaling relations of Birzan et al. (2008) to show that the AGN is underpowered compared to the central X-ray cooling luminosity by roughly a factor of three. We suggest that A1664 is experiencing rapid cooling and star formation during a low-state of an AGN feedback cycle that regulates the rates of cooling and star formation. Modeling the emission as a single temperature plasma, we find that the metallicity peaks 100 kpc from the X-ray center, resulting in a central metallicity dip. However, a multi-temperature cooling flow model improves the fit to the X-ray emission and is able to recover the expected, centrally-peaked metallicity profile. Next, using deep Chandra observations of the Hydra A galaxy cluster, we examine the metallicity structure near the central galaxy and along its powerful radio source. We show that the metallicity of the ICM is enhanced by up to 0.2 dex along the radio jets and lobes compared to the metallicity of the undisturbed gas. The enhancements extend from a radius of 20 kpc from the central galaxy to a distance of ~120 kpc. We estimate the total iron mass that has been transported out of the central galaxy to be between 2E7 and 7E7 solar masses which represents 10% - 30% of the iron mass within the central galaxy. The energy required to lift this gas is roughly 1% to 5% of the total energetic output of the AGN. Evidently, Hydra A’s powerful radio source is able to redistribute metal-enriched, low entropy gas throughout the core of the galaxy cluster. The short re-enrichment timescale < 1E9 yr implies that the metals lost from the central galaxy will be quickly replenished. Finally, we present an analysis of the spatial distribution of metal-rich gas in 29 galaxy clusters using deep observations from the Chandra X-ray Observatory. The BCGs have experienced recent active galactic nucleus activity in the forms of bright radio emission, cavities, and shock fronts embedded in the hot atmospheres. The heavy elements are distributed anisotropically and are aligned with the large-scale radio and cavity axes. They are apparently being transported from the halo of the BCG into the ICM along large-scale outflows driven by the radio jets. The radial ranges of the metal-enriched outflows are found to scale with jet power as R ~ P^0.43, with a scatter of only 0.42 dex. The heavy elements are transported beyond the extent of the inner cavities in all clusters, suggesting this is a long lasting effect sustained over multiple generations of outbursts. Black holes in BCGs will likely have difficulty ejecting metal enriched gas beyond 1 Mpc unless their masses substantially exceed 1E9 solar masses. It is likely however for these black holes to output enough energy to uplift all the peaked, metal-rich gas beyond the BCG to the currently observed widespread distribution

Implantation of silicon dioxide-based nanocrystalline hydroxyapatite and pure phase beta-tricalciumphosphate bone substitute granules in caprine muscle tissue does not induce new bone formation

Background: Osteoinductive bone substitutes are defined by their ability to induce new bone formation even at heterotopic implantation sites. The present study was designed to analyze the potential osteoinductivity of two different bone substitute materials in caprine muscle tissue. Materials and methods: One gram each of either a porous beta-tricalcium phosphate (β-TCP) or an hydroxyapatite/silicon dioxide (HA/SiO2)-based nanocrystalline bone substitute material was implanted in several muscle pouches of goats. The biomaterials were explanted at 29, 91 and 181 days after implantation. Conventional histology and special histochemical stains were performed to detect osteoblast precursor cells as well as mineralized and unmineralized bone matrix. Results: Both materials underwent cellular degradation in which tartrate-resistant acid phosphatase (TRAP)-positive osteoclast-like cells and TRAP-negative multinucleated giant cells were involved. The ß-TCP was completely resorbed within the observation period, whereas some granules of the HA-groups were still detectable after 180 days. Neither osteoblasts, osteoblast precursor cells nor extracellular bone matrix were found within the implantation bed of any of the analyzed biomaterials at any of the observed time points. Conclusions: This study showed that ß-TCP underwent a faster degradation than the HA-based material. The lack of osteoinductivity for both materials might be due to their granular shape, as osteoinductivity in goat muscle has been mainly attributed to cylindrical or disc-shaped bone substitute materials. This hypothesis however requires further investigation to systematically analyze various materials with comparable characteristics in the same experimental setting

RNA-DNA hybridization promoted by E.coli RecA portein

RecA protein of E. coli plays a central regulatory role that is induced by damage to DNA and results in the inactivation of LexA repressor. In vitro, RecA protein binds preferentially to single-stranded DNA to form a nucleoprotein filament that can recognize homology in naked duplex DNA and promote extensive strand exchange. Although RecA protein shows little tendency at neutral pH to bind to RNA, we found that it nonetheless catalyzed at 37 degrees C the hybridization of complementary RNA and single-stranded DNA sequences. Hybrids made by RecA protein at 37 degrees C appeared indistinguishable from ones prepared by thermal annealing. RNA-DNA hybridization by RecA protein at neutral pH required, as does RecA-promoted homologous pairing, optimal conditions for the formation of RecA nucleoprotein filaments. The cosedimentation of RNA with those filaments further paralleled observations made on the formation of networks of nucleoprotein filaments with double-stranded DNA, an instrumental intermediate in homologous pairing in vitro. These similarities with the pairing reaction support the view that RecA protein acts specifically in the hybridization reaction

The Fourteenth Data Release of the Sloan Digital Sky Survey : First Spectroscopic Data from the Extended Baryon Oscillation Spectroscopic Survey and from the Second Phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since 2014 July. This paper describes the second data release from this phase, and the 14th from SDSS overall (making this Data Release Fourteen or DR14). This release makes the data taken by SDSS-IV in its first two years of operation (2014-2016 July) public. Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey; the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data-driven machine-learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from the SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS web site (www.sdss.org) has been updated for this release and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020 and will be followed by SDSS-V.Peer reviewe

Notes on Captive Sea Otters

Notes on the behaviour of three yearlings kept two and a half months in 1954 in a dry environment at Amchitka in the Aleutians. Their sleeping, preening, reaction to man and feeding habits, drinking, locomotion, handling, food and sociability voice, etc., are discussed in detail. Their anatomy and environment in captivity are also discussed: water for swimming was found desirable, if not necessary. Results of physiological investigations are reported by D.E. Stullken and C.M. Kirkpatrick, q.v