CRM-система как инструмент повышения эффективности деятельности компании

Объектом исследования является ООО "СМЕТ". Предметом исследования является управление взаимоотношениями с клиентами. Цель работы – рассмотрение CRM-систем как инструмент повышения эффективности бизнеса. Актуальность работы: в новых условиях компаниям продавать свои товары и услуги и удерживать клиентов стало намного сложнее. Клиенты стали тщательнее "считать деньги", торговаться и экономить. Покупательский спрос смещается в сторону более дешевых предложений, клиенты отказываются от всего дополнительного и необязательного, сопутствующих товаров. Усиливается конкуренция на рынках внутри страны.The object of this study is LLC "ESTIMATES". The subject of this study is customer relationship management. Purpose - consideration of CRM-systems as a tool to improve business performance. Relevance of the work: under the new conditions the companies sell their products and services and hold the customer has become much more difficult. Customers have become more thoroughly "counting money" to trade and save. Consumer demand shifts toward lower-cost offerings, customers abandon all the extra and optional, related products. There is a growing competition in the domestic markets and with foreign companies

Модернизация теплообменных аппаратов различной производительности на основе численного моделирования

Выпускная квалификационная работа 104 с., 49 рис., 10 табл., 20 источников, 3 прил. Ключевые слова: математическое моделирование, теплообменник, топливный газ, интенсификаторы теплообмена, принудительная конвекция, турбулентность, расчетная сетка, присоединительный вихрь, тепловой поток, геометрическая модель. Объектом исследования является теплообменный аппарат, применяемый для нагрева топливного газа перед подачей его на горелочные устройства. Цель работы - исследование интенсифицированного теплообмена при турбулентном течении теплоносителя в прямых круглых трубах с итенсификаторами теплообмена и анализ эффективности различных турбулизаторов.Final qualifying work 104 p., 49 fig., 10 tab., 20 sources, 3 application. Keywords: mathematical modeling, heat exchanger, fuel gas, to vary the heat transfer, forced convection, turbulence, computational grid, connecting a whirlwind, heat flow, the geometric model. The object of research is the heat exchanger that is used to heat the fuel gas before it is fed to the burners. Objective - research intensified heat exchange in turbulent flow of coolant in straight circular pipes with itensifikatorami heat exchange and analysis of the effectiveness of different turbulence. The study was carried out mathematical modeling of the object of study with the use of ANSYS package applications, analysis of the results and evaluation of the effectiveness of different types of turbulence

Systematic Analysis of Gene Expression Differences between Left and Right Atria in Different Mouse Strains and in Human Atrial Tissue

Background: Normal development of the atria requires left-right differentiation during embryonic development. Reduced expression of Pitx2c (paired-like homeodomain transcription factor 2, isoform c), a key regulator of left-right asymmetry, has recently been linked to atrial fibrillation. We therefore systematically studied the molecular composition of left and right atrial tissue in adult murine and human atria. Methods: We compared left and right atrial gene expression in healthy, adult mice of different strains and ages by employing whole genome array analyses on freshly frozen atrial tissue. Selected genes with enriched expression in either atrium were validated by RT-qPCR and Western blot in further animals and in shock-frozen left and right atrial appendages of patients undergoing open heart surgery. Results: We identified 77 genes with preferential expression in one atrium that were common in all strains and age groups analysed. Independent of strain and age, Pitx2c was the gene with the highest enrichment in left atrium, while Bmp10, a member of the TGFb family, showed highest enrichment in right atrium. These differences were validated by RT-qPCR in murine and human tissue. Western blot showed a 2-fold left-right concentration gradient in PITX2 protein in adult human atria. Several of the genes and gene groups enriched in left atria have a known biological role for maintenance of healthy physiology, specifically the prevention of atrial pathologies involved in atrial fibrillation, including membrane electrophysiology, metabolic cellular function, and regulation of inflammatory processes. Comparison of the array datasets with published array analyses in heterozygous Pitx2c+/2 atria suggested that approximately half of the genes with left-sided enrichment are regulated by Pitx2c. Conclusions: Our study reveals systematic differences between left and right atrial gene expression and supports the hypothesis that Pitx2c has a functional role in maintaining ‘‘leftness’’ in the atrium in adult murine and human hearts

Упрощенная система учета и налогообложения

Объём работы – 76 с., иллюстраций – 2, таблиц – 12, формул – 2, источников – 52. Актуальность выбранной темы исследования заключается в уникальности КПКГ, как некоммерческих организаций, подлежащих упрощенной системе налогообложения, несмотря на наличие в них кредиторской деятельности. Объектом исследования является кредитно-потребительский кооператив граждан «Традиция». Предмет исследования – упрощенная система налогообложения КПКГ. Цель ВКР – исследование сущности и практики применения упрощенной системы налогообложения потребительских кредитных кооперативов граждан на примере КПКГ «Традиция».Volume of work - 76, illustration -. 2, tables - 12, formulas - 2, sources - 52. The relevance of the chosen research topic is unique CCCC as non-profit organizations are subject to a simplified system of taxation, despite the presence of accounts activity. The object of this study is to credit and consumer cooperative citizens "Tradition". Subject of research - the simplified taxation system CCCC. The purpose of the WRC - study the nature and practice of application of the simplified tax system consumer credit cooperatives of citizens the example of CCCC "Tradition"

Jatropha Curcas Development as Intervention Potential to Tackling Land, Energy and Food Challenges of Rural Communities in Dryland Sub-Saharan Africa

Global population growth is placing increasing pressures on land for food and feed production as well as energy security. In particular in sub-Saharan Africa (SSA), these issues require urgent attention. This is clearly stated in The United Nations Global Goals for Sustainable Development emphasizing the importance of sustainable use of land resources to increase food productivity and energy requirement. SSA lags behind most regions of the world in household food security and access to energy. The rural agriculture-dependent communities of SSA are the hardest hit by food and energy scarcity and the impact is felt most by communities in the dryland farming areas. In terms of energy supply appropriate measures and interventions are required to address this challenge. Jatropha curcas L. oil fast tracked itself from obscurity to prominence. Its main advantage is the high content of methyl ester (or bio-diesel). It conforms to EN 14214 specifications, exhibiting emission reduction potential and qualifying as a lucrative bio-diesel alternative to fossil diesel. This paper proposes a focus on Jatropha technology as a holistic approach to tackling the land, energy and food degradation challenges in unison for dry-land SSA. The new Jatropha strategy would be innovative and environmentally friendly soil resource recapitalization and supply feed stock for rural energy generation while fulfilling the criteria of delivering other benefits, such as addressing land use conflict for food and energy production

Разработка технологии ремонта и восстановления корпуса буксы оси колесной пары грузового вагона

Реферат Выпускная квалификационная работа 105 с., 0 рисунков, 23 таблицы, 24 источник, 2 приложения, 9 л. графического материала. Ключевые слова: наплавка, технология, режимы сварки, сила сварочного тока, сварочное оборудование, производительность, план участка, кантователь, промышленная безопасность, себестоимость. Актуальность работы: в данной выпускной квалификационной работе производится ремонт и восстановление корпуса буксы оси колесной пары грузового вагона. Объектом исследования является процесс восстановления корпус буксы. Цели и задачи исследования (работы). В результате данной работы следует получить производство с наибольшей степенью механизации и автоматизации повышающей производительность труда. Работа представлена введением, пятью разделами (главами) и заключением, приведен список использованных источников. В 1разделе/главе «Обзор литературы» произведен обзор литературы. Во 2 разделе/главе «Объект и методы исследования» Произведена формулировка проектной задачи и теоретический анализ. В 3 разделе/главе «Результаты проведенного исследования» Произведен инженерный расчет, рассмотрены конструкторская, технологическая и организационная части, рассмотрено пространственное расположение производственного процесса. В 4 разделе/главе «Финансовый менеджмент, ресурсоэффективность и ресурсосбережение» рассмотрены сравнительный экономический анализ вариантов, расчет технико-экономической эффективности, основные технико-экономические показатели участка. В 5 разделе/главе «Социальная ответственность» рассмотрена характеристика объекта исследования, вредные и опасные производственные факторы, источники и средства защиты от них, влияние их на организм человека и проектирование системы приточно-вытяжной вентиляции на разрабатываемом участке. В заключении приведено обоснование выбора способов сварки, сварочных материалов и оборудования. Разработаны мероприятия по безопасности жизнедеятельности, охране труда и совершенствованию организации труда. Посчитан экономический эффект от перечисленных нововведений, что позволяет судить о выгодности предлагаемого технологического процесса.Abstract Final qualifying work 105 pp., 0 pictures, 23 tables, 24 source, 2 applications 9 l. graphic material. Tags: welding technology, welding conditions, the welding current, welding equipment, performance, site plan, tilter, safety, costs. Relevance of the work: in the final qualifying work is carried out repair and restoration of the body axis of the wheel pair axle box of freight wagon. The object of research is the process of restoring the body of the journal box. The aims and objectives of the study (work). As a result of this work should be obtained from producing the greatest degree of mechanization and automation increases productivity. The work provides an introduction, five sections (chapters) and conclusion, a list of sources used. In 1razdele / chapter "Literature Review" produced a literature review. In the 2nd section / chapter "Object and Methods" Produced formulation of project objectives and theoretical analysis. In Section 3 / Chapter "The results of the study" Made engineering calculation, considered design, technological and organizational part, examined the spatial arrangement of the production process. a comparative economic analysis of the options discussed in Section 4 / Chapter "Financial management, resource efficiency and resource conservation", the calculation of technical and economic efficiency, the main technical and economic indicators of the site. In section 5 / chapter "Social responsibility" is considered characteristic of the object of study, harmful and dangerous production factors, sources and means of protection against them, their influence on the human body and design the system ventilation on the site to be developed. In conclusion, given rationale for the selection of welding, welding consumables and equipment. Actions on health and safety, labor protection and improvement of the labor organization. Calculate the economic impact of these innovations, which gives an indication of the profitability of the proposed proces

The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results.

Atrial fibrillation (AF) is the most common sustained arrhythmia in the general population. As an age-related arrhythmia AF is becoming a huge socio-economic burden for European healthcare systems. Despite significant progress in our understanding of the pathophysiology of AF, therapeutic strategies for AF have not changed substantially and the major challenges in the management of AF are still unmet. This lack of progress may be related to the multifactorial pathogenesis of atrial remodelling and AF that hampers the identification of causative pathophysiological alterations in individual patients. Also, again new mechanisms have been identified and the relative contribution of these mechanisms still has to be established. In November 2010, the European Union launched the large collaborative project EUTRAF (European Network of Translational Research in Atrial Fibrillation) to address these challenges. The main aims of EUTRAF are to study the main mechanisms of initiation and perpetuation of AF, to identify the molecular alterations underlying atrial remodelling, to develop markers allowing to monitor this processes, and suggest strategies to treat AF based on insights in newly defined disease mechanisms. This article reports on the objectives, the structure, and initial results of this network

Оценка инвестиционной деятельности электроэнергетической компании

Объектом исследования является электроэнергетическая компания ПАО «ТРК». Предметом исследования выступают оценка эффективности инвестиций и инвестиционная деятельность предприятий электроэнергетики. Цель работы - анализ показателей оценки эффективности инвестиционной деятельности и разработка рекомендаций по совершенствованию оценки инвестиционной деятельности на примере компании ПАО «Томская распределительная компания».The object of this study is to electric power company PJSC "TRK". The subject of research are the evaluation of the effectiveness of investments and investment activity of the enterprises of electric power industry. Purpose - analysis of indicators for assessing the effectiveness of investment and development of recommendations to improve the assessment of investment activity on the example of the company PJSC "Tomsk Distribution Company"

Arousal, Sleep and Cardiovascular Responses to Intermittent Hypercapnic Hypoxia in Piglets

Clinical studies have demonstrated an arousal deficit in infants suffering Obstructive Sleep Apnoea (OSA), and that treatment to alleviate the symptoms of OSA appears to reverse the deficit in arousability. Some sudden infant deaths are thought to be contingent upon such an arousal deficit. This research utilised young piglets during early postnatal development, and exposed them to intermittent hypercapnic hypoxia (IHH) as a model of clinical respiratory diseases. Arousal responses of control animals were compared to the animals exposed to IHH. Comparisons were also made between successive exposures on the first and the fourth consecutive days of IHH. Time to arouse after the onset of the respiratory stimulus, and frequency of arousals during recovery, demonstrated that arousal deficits arose after successive exposures and that these were further exacerbated on the fourth study day. After an overnight recovery period, the arousal deficit was apparently dormant, and only triggered by HH exposure. These studies confirm that both acute and chronic deficits can be induced on a background of otherwise normal postnatal development, suggesting that deficits observed in the clinical setting may be a secondary phenomenon