Efficiency Improvement of a Plant Layout

Abstract: Facilities layout is a systematic and functional arrangement of different departments, machines, equipments and services in a manufacturing industry. It is essential to have a well developed plant layout for all the available resources in an optimum manner and get the maximum out of the capacity of the facilities. The efficiency of production depends on how well the various machines, services production facilities and employee's amenities are located in a plant. This research paper aims to study and improve the current plant layout and are analysed & designed by using string diagram. An Attempt is made to simulate the current and proposed factory layout by using ARENA software. Efficiency of the current & proposed plant layout are calculated

Exploration of Allosteric Agonism Structure–Activity Relationships within an Acetylene Series of Metabotropic Glutamate Receptor 5 (mGlu₅) Positive Allosteric Modulators (PAMs): Discovery of 5‑((3-Fluorophenyl)ethynyl)‑<i>N</i>‑(3-methyloxetan-3-yl)picolinamide (ML254)

Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGlu₅) represent a promising therapeutic strategy for the treatment of schizophrenia. Both allosteric agonism and high glutamate fold-shift have been implicated in the neurotoxic profile of some mGlu₅ PAMs; however, these hypotheses remain to be adequately addressed. To develop tool compounds to probe these hypotheses, the structure–activity relationship of allosteric agonism was examined within an acetylenic series of mGlu₅ PAMs exhibiting allosteric agonism in addition to positive allosteric modulation (ago-PAMs). PAM <b>38t</b>, a low glutamate fold-shift allosteric ligand (maximum fold-shift ∼3.0), was selected as a potent PAM with no agonism in the in vitro system used for compound characterization and in two native electrophysiological systems using rat hippocampal slices. PAM <b>38t</b> (ML254) will be useful to probe the relative contribution of cooperativity and allosteric agonism to the adverse effect liability and neurotoxicity associated with this class of mGlu₅ PAMs