A Reporting Framework for Describing and a Typology for Categorizing and Analyzing the Designs of Health Care Pay for Performance Schemes

Table S1. Search strategy output for Cochrane database. This table details the search strategy employed to identify relevant studies and reviews used in the manuscript. This includes the database searched, years covered, and number of citations. Table S2. Summary of identified reviews. This table outlines the relevant reviews and P4P evaluation studies identified from our search strategy, which informed our reporting framework and typology. Table S3. Search strategy output for economic theories to inform the P4P typology. This table details the search strategy employed to identify relevant economic theories that were used to construct the P4P typology. This includes the database searched, years covered, and number of citations. Table S4. Application of the typology on selected identified P4P schemes. This table outlines the results of applying the P4P typology to categorized identified P4P schemes. Table S5. P4P studies used in testing the inter-rater reliability of the P4P typology. This table list out the P4P studies that were selected for the raters to apply the P4P typology. Table S6. Rater population. This table describes the rater population i.e. qualifications, research experience, and experience with P4P in healthcare. Table S7. Sources of disagreement between raters. This table highlights the items on the P4P typology that were sources of disagreement between he raters. Table S8. An example of source of disagreement between raters (risk). This table details text extracts from the sample P4P study and describes the reason for disagreement between raters testing the P4P typology. (DOCX 127 kb

The significance of variation in the susceptibility of Schistosoma mansoni to the antischistosomal drug oxamniquine

Clinical and laboratory evidence is reviewed which shows that there is a great deal of variation in the susceptibility of Schistosoma mansoni to oxamniquine. This variation occurs both among endemic regions and within endemic regions in Brazil and Kenya. It is genetically controlled. It is suggested that the parasite possesses a large capacity for developing resistance to the drug and that resistance will develop where sufficient drug pressure is maintained