Tabulation, bibliography, and structure of binary intermetallic compounds. V. Compounds of aluminum and indium

This report is the fifth and last in a series. The previous reports listed the compounds of elements

The ion-induced charge-exchange X-ray emission of the Jovian Auroras: Magnetospheric or solar wind origin?

A new and more comprehensive model of charge-exchange induced X-ray emission, due to ions precipitating into the Jovian atmosphere near the poles, has been used to analyze spectral observations made by the Chandra X-ray Observatory. The model includes for the first time carbon ions, in addition to the oxygen and sulfur ions previously considered, in order to account for possible ion origins from both the solar wind and the Jovian magnetosphere. By comparing the model spectra with newly reprocessed Chandra observations, we conclude that carbon ion emission provides a negligible contribution, suggesting that solar wind ions are not responsible for the observed polar X-rays. In addition, results of the model fits to observations support the previously estimated seeding kinetic energies of the precipitating ions (~0.7-2 MeV/u), but infer a different relative sulfur to oxygen abundance ratio for these Chandra observations.Comment: 11 pages, 2 figures, 2 tables, submitted to ApJ Lette

Solid State Physics

Contains reports on five research projects

Exploring Cancer Outcomes of People With and Without Pre-existing Anxiety and/or Depression Following Symptomatic Presentation to Healthcare: A Scoping Review

What are the cancer outcomes in people with pre-existing anxiety and/or depression? A secondary aim is to explore the extent of evidence on possible reasons underlying differences in cancer outcomes between people with and without anxiety and/or depressionObjective: The objective of this scoping review is to collate the literature on cancer outcomes and highlight where any disparities occur for people with anxiety and/or depression, enabling exploration of the reasons behind those factors. Introduction: Around 375,000 people in the UK are diagnosed with cancer annually. Individuals with mental health disorders have a 30% higher case fatality rate from cancer compared to individuals without. Each year, 5-7% of urgent suspected-cancer hospital appointments are missed, with anxiety and depression possible causes, and survival is worse following emergency diagnoses. Inclusion criteria: Studies that report differences/disparities in cancer diagnostic processes/outcomes between people with/without pre-existing anxiety and/or depression will be included. Methods: The databases MEDLINE, PsycINFO, EMBASE and CINAHL will be searched for articles between 2015 and 2024. Additional articles will be sourced using forward and backward citations. Two researchers will screen the articles for eligibility against the inclusion criteria. Qualifying articles will be quality appraised. The search results will be presented using the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for scoping review (PRISMA-ScR). The final articles will be presented in a narrative synthesis supplemented with thematic analysis if appropriate.National Institute for Health and Care Research (NIHR

Replacement of the Trabecular Meshwork Cells—A Way Ahead in IOP Control?

Glaucoma is one of the leading causes of vision loss worldwide, characterised with irreversible optic nerve damage and progressive vision loss. Primary open-angle glaucoma (POAG) is a subset of glaucoma, characterised by normal anterior chamber angle and raised intraocular pressure (IOP). Reducing IOP is the main modifiable factor in the treatment of POAG, and the trabecular meshwork (TM) is the primary site of aqueous humour outflow (AH) and the resistance to outflow. The structure and the composition of the TM are key to its function in regulating AH outflow. Dysfunction and loss of the TM cells found in the natural ageing process and more so in POAG can cause abnormal extracellular matrix (ECM) accumulation, increased TM stiffness, and increased IOP. Therefore, repair or regeneration of TM’s structure and function is considered as a potential treatment for POAG. Cell transplantation is an attractive option to repopulate the TM cells in POAG, but to develop a cell replacement approach, various challenges are still to be addressed. The choice of cell replacement covers autologous or allogenic approaches, which led to investigations into TM progenitor cells, induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs) as potential stem cell source candidates. However, the potential plasticity and the lack of definitive cell markers for the progenitor and the TM cell population compound the biological challenge. Morphological and differential gene expression of TM cells located within different regions of the TM may give rise to different cell replacement or regenerative approaches. As such, this review describes the different approaches taken to date investigating different cell sources and their differing cell isolation and differentiation methodologies. In addition, we highlighted how these approaches were evaluated in different animal and ex vivo model systems and the potential of these methods in future POAG treatment

Solid State Physics

Contains reports on three research projects

Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS)

Background: Little is known about how dependency levels have changed between generational cohorts of older people. We estimated years lived in different care states at age 65 in 1991 and 2011 and new projections of future demand for care. Methods: Two population-based studies of older people in defined geographical areas conducted two decades apart (the Cognitive Function and Ageing Studies) provided prevalence estimates of dependency in four states: high (24-hour care); medium (daily care); low (less than daily); independent. Years in each dependency state were calculated by Sullivan’s method. To project future demand, the proportions in each dependency state (by age group and sex) were applied to the 2014 England population projections. Findings: Between 1991 and 2011 there were significant increases in years lived from age 65 with low (men:1·7 years, 95%CI 1·0-2·4; women:2·4 years, 95%CI 1·8-3·1) and high dependency (men:0·9 years, 95%CI 0·2-1·7; women:1·3 years, 95%CI 0·5-2·1). The majority of men’s extra years of life were independent (36%) or with low dependency (36%) whilst for women the majority were spent with low dependency (58%), only 5% being independent. There were substantial reductions in the proportions with medium and high dependency who lived in care homes, although, if these dependency and care home proportions remain constant in the future, further population ageing will require an extra 71,000 care home places by 2025. Interpretation: On average older men now spend 2.4 years and women 3.0 years with substantial care needs (medium or high dependency), and most will live in the community. These findings have considerable implications for older people’s families who provide the majority of unpaid care, but the findings also supply valuable new information for governments and care providers planning the resources and funding required for the care of their future ageing populations