Carlo Goldoni and the 18th century London stage

This is an investigation into Goldoni's working relationship as a librettist with the King's Theatre in London and it covers the period between 1749 and 1793. The King's Theatre was known as the Italian Opera House and Goldoni was invited to write libretti for its productions. This he did successfully - so successfully that he can be said to have become an integral part of the cultural life of an exalted section of London society. The cultural climate in London in the 18th century favoured entertainments such as pantomime, farce and burlesque, that had derived from or imitated Commedia dell'Arte. This liking for traditional theatrical forms was a European phenomenon and had its roots in the theatre of Shakespeare in England as well as in the popular and the classical theatre in Prance. In Italy the Commedia dell'Arte never really died, although in the 18th century Goldoni tried to free himself from it in an attempt to modernise the Italian theatre. But even so, Commedia dell'Arte survived in libretti of the type Goldoni was writing and which proved suitable for Comic Opera. This was the result of an evolution from simpler musical forms such as intermezzi and cantata a llengua and soon rivalled Opera Seria in popularity. In the second half of the century and under the influence of proto-Romanticism comic-opera libretti became increasingly sentimental, a trend which was reflected in Goldoni's own libretti for this type of theatrical entertainment. Comic Opera was evolving in the direction of the type of "melodrama" which was to dominate the theatre of the 19th century. In this context Goldoni's La Buona Figliuola - one of the great successes of the King's Theatre - demonstrates that while preserving links with a traditional past Goldoni seemed to be looking forward to a future development in Comic-Opera libretti, which, dying as he did in 1793, he was not to live to see.<p

Demographic Disparities in 1-to-Many Facial Identification

Most studies to date that have examined demographic variations in face recognition accuracy have analyzed 1-to-1 matching accuracy, using images that could be described as "government ID quality". This paper analyzes the accuracy of 1-to-many facial identification across demographic groups, and in the presence of blur and reduced resolution in the probe image as might occur in "surveillance camera quality" images. Cumulative match characteristic curves(CMC) are not appropriate for comparing propensity for rank-one recognition errors across demographics, and so we introduce three metrics for this: (1) d' metric between mated and non-mated score distributions, (2) absolute score difference between thresholds in the high-similarity tail of the non-mated and the low-similarity tail of the mated distribution, and (3) distribution of (mated - non-mated rank one scores) across the set of probe images. We find that demographic variation in 1-to-many accuracy does not entirely follow what has been observed in 1-to-1 matching accuracy. Also, different from 1-to-1 accuracy, demographic comparison of 1-to-many accuracy can be affected by different numbers of identities and images across demographics. Finally, we show that increased blur in the probe image, or reduced resolution of the face in the probe image, can significantly increase the false positive identification rate. And we show that the demographic variation in these high blur or low resolution conditions is much larger for male/ female than for African-American / Caucasian. The point that 1-to-many accuracy can potentially collapse in the context of processing "surveillance camera quality" probe images against a "government ID quality" gallery is an important one.Comment: 9 pages, 8 figures, Conference submissio

In-situ high temperature spatially resolved X-ray diffraction of TiB2 up to ~3250 ˚C

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Environmental conical nozzle levitator equipped with dual lasers

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The Alström Syndrome Protein, ALMS1, Interacts with α-Actinin and Components of the Endosome Recycling Pathway

Alström syndrome (ALMS) is a progressive multi-systemic disorder characterized by cone-rod dystrophy, sensorineural hearing loss, childhood obesity, insulin resistance and cardiac, renal, and hepatic dysfunction. The gene responsible for Alström syndrome, ALMS1, is ubiquitously expressed and has multiple splice variants. The protein encoded by this gene has been implicated in ciliary function, cell cycle control, and intracellular transport. To gain better insight into the pathways through which ALMS1 functions, we carried out a yeast two hybrid (Y2H) screen in several mouse tissue libraries to identify ALMS1 interacting partners. The majority of proteins found to interact with the murine carboxy-terminal end (19/32) of ALMS1 were α-actinin isoforms. Interestingly, several of the identified ALMS1 interacting partners (α-actinin 1, α-actinin 4, myosin Vb, rad50 interacting 1 and huntingtin associated protein1A) have been previously associated with endosome recycling and/or centrosome function. We examined dermal fibroblasts from human subjects bearing a disruption in ALMS1 for defects in the endocytic pathway. Fibroblasts from these patients had a lower uptake of transferrin and reduced clearance of transferrin compared to controls. Antibodies directed against ALMS1 N- and C-terminal epitopes label centrosomes and endosomal structures at the cleavage furrow of dividing MDCK cells, respectively, suggesting isoform-specific cellular functions. Our results suggest a role for ALMS1 variants in the recycling endosome pathway and give us new insights into the pathogenesis of a subset of clinical phenotypes associated with ALMS

The Child and Parent Emotion Study: Protocol for a longitudinal study of parent emotion socialisation and child socioemotional development

Introduction:&nbsp;Parents shape child emotional competence and mental health via their beliefs about children&rsquo;s emotions, emotion-related parenting, the emotional climate of the family and by modelling emotion regulation skills. However, much of the research evidence to date has been based on small samples with mothers of primary school-aged children. Further research is needed to elucidate the direction and timing of associations for mothers and fathers/partners across different stages of child development. The Child and Parent Emotion Study (CAPES) aims to examine longitudinal associations between parent emotion socialisation, child emotion regulation and socioemotional adjustment at four time points from pregnancy to age 12 years. CAPES will investigate the moderating role of parent gender, child temperament and gender, and family background.Methods and analysis:&nbsp;CAPES recruited 2063 current parents from six English-speaking countries of a child 0&ndash;9 years and 273 prospective parents (ie, women/their partners pregnant with their first child) in 2018&ndash;2019. Participants will complete a 20&ndash;30 min online survey at four time points 12 months apart, to be completed in December 2022. Measures include validated parent-report tools assessing parent emotion socialisation (ie, parent beliefs, the family emotional climate, supportive parenting and parent emotion regulation) and age-sensitive measures of child outcomes (ie, emotion regulation and socioemotional adjustment). Analyses will use mixed-effects regression to simultaneously assess associations over three time-point transitions (ie, T1 to T2; T2 to T3; T3 to T4), with exposure variables lagged to estimate how past factors predict outcomes 12 months later.Ethics and dissemination:&nbsp;Ethics approval was granted by the Deakin University Human Research Ethics Committee and the Deakin University Faculty of Health Human Research Ethics Committee. We will disseminate results through conferences and open access publications. We will invite parent end users to co-develop our dissemination strategy, and discuss the interpretation of key findings prior to publication.Trial registeration:&nbsp;Protocol pre-registration: DOI 10.17605/OSF.IO/NGWUY.</jats:sec

Catalytic asymmetric synthesis of the alkaloid (+)-myrtine

A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4-piperidones has been developed using a catalytic enantioselective conjugate addition reaction in combination with a diastereoselective lithiation–substitution sequence; an efficient synthesis of (+)-myrtine has been achieved via this route.

Eliminating HIV transmission through breast milk from women taking antiretroviral drugs

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