Felix Schürmann, Der graue Unterstrom. Walfänger und Küstengesellschaften an den tiefen Stränden Afrikas (1770–1920). (Globalgeschichte, Bd. 25.) Frankfurt am Main, Campus 2017

Dieser Beitrag ist mit Zustimmung des Rechteinhabers (De Gruyter) frei zugänglich.Peer Reviewe

Bathsheba Demuth, Floating Coast. An Environmental History of the Bering Strait. London, Norton 2019

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.Peer Reviewe

Martina Winkler, Das Imperium und die Seeotter. Die Expansion Russlands in den nordpazifischen Raum, 1700–1867. (Transnationale Geschichte, Bd. 9.) Göttingen, Vandenhoeck & Ruprecht 2016

Dieser Beitrag ist mit Zustimmung des Rechteinhabers (De Gruyter) frei zugänglich.Peer Reviewe

Karl Schlögel, Das sowjetische Jahrhundert. Archäologie einer untergegangenen Welt. München, Beck 2017

Dieser Beitrag ist mit Zustimmung des Rechteinhabers (De Gruyter) frei zugänglich.Peer Reviewe

State independent QKD

We present an adaptive procedure for aligning quantum non-locality experiments without any knowledge of the two-qudit state shared by the participating parties. The quantum state produced by the source, its unitary evolution as well as the actual measurement bases remain unknown to both parties at all times. The entanglement of the quantum state helps establish desired correlations between individual measurement bases of the two distant parties. We implement the procedure in a fiber-based quantum key distribution (QKD) setup with polarization-entangled photons, where we do not rely on any additional alignment tools such as lasers or polarizers. In a QKD scenario the procedure can be done without any additional measurements as those that are performed regardless.Comment: 8 pages, 5 figure

Distribution of genuine high-dimensional entanglement over 10.2 km of noisy metropolitan atmosphere

In a recent quantum key distribution experiment, high-dimensional protocols were used to show an improved noise resistance over a 10.2 km free-space channel. One of the unresolved questions in this context is whether the communicating parties actually shared genuine high-dimensional entanglement. In this letter we introduce an improved discretisation and entanglement certification scheme for high-dimensional time-bin setups and apply it to the data obtained during the experiment. Our analysis answers the aforementioned question affirmatively and thus the experiment constitutes the first transmission of genuine high-dimensional entanglement in a single degree of freedom over a long-range free-space channel.Comment: 6 pages, 3 figure

Central Sensitivity Syndromes: Mounting Pathophysiologic Evidence to Link Fibromyalgia with Other Common Chronic Pain Disorders

ABSTRACT: The aim of this study was to review emerging data from the fields of nursing, rheumatology, dentistry, gastroenterology, gynecology, neurology, and orthopedics that support or dispute pathophysiologic similarities in pain syndromes studied by each specialty. A literature search was performed through PubMed and Ovid using the terms fibromyalgia, temporomandibular joint disorder, irritable bowel syndrome, irritable bladder/interstitial cystitis, headache, chronic low back pain, chronic neck pain, functional syndromes, and somatization. Each term was linked with pathophysiology and/or central sensitization. This paper presents a review of relevant articles with a specific goal of identifying pathophysiologic findings related to nociceptive processing. The extant literature presents considerable overlap in the pathophysiology of these diagnoses. Given the psychosomatic lens through which many of these disorders are viewed, demonstration of evidence-based links supporting shared pathophysiology between these disorders could provide direction to clinicians and researchers working to treat these diagnoses. ''Central sensitivity syndromes'' denotes an emerging nomenclature that could be embraced by researchers investigating each of these disorders. Moreover, a shared paradigm would be useful in promoting crossfertilization between researchers. Scientists and clinicians could most effectively forward the understanding and treatment of fibromyalgia and other common chronic pain disorders through an appreciation of their shared pathophysiology

Cross-species variability in lobular geometry and cytochrome P450 hepatic zonation: insights into CYP1A2, CYP2D6, CYP2E1 and CYP3A4

There is a lack of systematic research exploring cross-species variation in liver lobular geometry and zonation patterns of critical drug-metabolizing enzymes, a knowledge gap essential for translational studies. This study investigated the critical interplay between lobular geometry and key cytochrome P450 (CYP) zonation in four species: mouse, rat, pig, and human. We developed an automated pipeline based on whole slide images (WSI) of hematoxylin-eosin-stained liver sections and immunohistochemistry. This pipeline allows accurate quantification of both lobular geometry and zonation patterns of essential CYP proteins. Our analysis of CYP zonal expression shows that all CYP enzymes (besides CYP2D6 with panlobular expression) were observed in the pericentral region in all species, but with distinct differences. Comparison of normalized gradient intensity shows a high similarity between mice and humans, followed by rats. Specifically, CYP1A2 was expressed throughout the pericentral region in mice and humans, whereas it was restricted to a narrow pericentral rim in rats and showed a panlobular pattern in pigs. Similarly, CYP3A4 is present in the pericentral region, but its extent varies considerably in rats and appears panlobular in pigs. CYP2D6 zonal expression consistently shows a panlobular pattern in all species, although the intensity varies. CYP2E1 zonal expression covered the entire pericentral region with extension into the midzone in all four species, suggesting its potential for further cross-species analysis. Analysis of lobular geometry revealed an increase in lobular size with increasing species size, whereas lobular compactness was similar. Based on our results, zonated CYP expression in mice is most similar to humans. Therefore, mice appear to be the most appropriate species for drug metabolism studies unless larger species are required for other purposes, e.g., surgical reasons. CYP selection should be based on species, with CYP2E1 and CYP2D6 being the most preferable to compare four species. CYP1A2 could be considered as an additional CYP for rodent versus human comparisons, and CYP3A4 for mouse/human comparisons. In conclusion, our image analysis pipeline together with suggestions for species and CYP selection can serve to improve future cross-species and translational drug metabolism studies.Peer Reviewe