27 research outputs found
Tunable coupling to a mechanical oscillator circuit using a coherent feedback network
We demonstrate a fully cryogenic microwave feedback network composed of
modular superconducting devices connected by transmission lines and designed to
control a mechanical oscillator coupled to one of the devices. The network
features an electromechanical device and a tunable controller that coherently
receives, processes and feeds back continuous microwave signals that modify the
dynamics and readout of the mechanical state. While previous electromechanical
systems represent some compromise between efficient control and efficient
readout of the mechanical state, as set by the electromagnetic decay rate, the
tunable controller produces a closed-loop network that can be dynamically and
continuously tuned between both extremes much faster than the mechanical
response time. We demonstrate that the microwave decay rate may be modulated by
at least a factor of 10 at a rate greater than times the mechanical
response rate. The system is easy to build and suggests that some useful
functions may arise most naturally at the network-level of modular, quantum
electromagnetic devices.Comment: 11 pages, 6 figures, final published versio
A Compact Cold-Atom Interferometer with a High Data-Rate Grating Magneto-Optical Trap and a Photonic-Integrated-Circuit-Compatible Laser System
The extreme miniaturization of a cold-atom interferometer accelerometer
requires the development of novel technologies and architectures for the
interferometer subsystems. Here we describe several component technologies and
a laser system architecture to enable a path to such miniaturization. We
developed a custom, compact titanium vacuum package containing a
microfabricated grating chip for a tetrahedral grating magneto-optical trap
(GMOT) using a single cooling beam. In addition, we designed a multi-channel
photonic-integrated-circuit-compatible laser system implemented with a single
seed laser and single sideband modulators in a time-multiplexed manner,
reducing the number of optical channels connected to the sensor head. In a
compact sensor head containing the vacuum package, sub-Doppler cooling in the
GMOT produces 15 uK temperatures, and the GMOT can operate at a 20 Hz data
rate. We validated the atomic coherence with Ramsey interferometry using
microwave spectroscopy, then demonstrated a light-pulse atom interferometer in
a gravimeter configuration for a 10 Hz measurement data rate and T = 0 - 4.5 ms
interrogation time, resulting in g / g = 2.0e-6. This work represents
a significant step towards deployable cold-atom inertial sensors under large
amplitude motional dynamics.Comment: 21 pages, 10 figure
Measuring the predictability of life outcomes with a scientific mass collaboration.
How predictable are life trajectories? We investigated this question with a scientific mass collaboration using the common task method; 160 teams built predictive models for six life outcomes using data from the Fragile Families and Child Wellbeing Study, a high-quality birth cohort study. Despite using a rich dataset and applying machine-learning methods optimized for prediction, the best predictions were not very accurate and were only slightly better than those from a simple benchmark model. Within each outcome, prediction error was strongly associated with the family being predicted and weakly associated with the technique used to generate the prediction. Overall, these results suggest practical limits to the predictability of life outcomes in some settings and illustrate the value of mass collaborations in the social sciences
Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTICâHF: baseline characteristics and comparison with contemporary clinical trials
Aims:
The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTICâHF) trial. Here we describe the baseline characteristics of participants in GALACTICâHF and how these compare with other contemporary trials.
Methods and Results:
Adults with established HFrEF, New York Heart Association functional class (NYHA)ââ„âII, EF â€35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokineticâguided dosing: 25, 37.5 or 50âmg bid). 8256 patients [male (79%), nonâwhite (22%), mean age 65âyears] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NTâproBNP 1971âpg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTICâHF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressureâ<â100âmmHg (n = 1127), estimated glomerular filtration rate <â30âmL/min/1.73 m2 (n = 528), and treated with sacubitrilâvalsartan at baseline (n = 1594).
Conclusions:
GALACTICâHF enrolled a wellâtreated, highârisk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation
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Generation and Efficient Measurement of Single Photons Using Superconducting Circuits
In this thesis, I demonstrate and evaluate an on-demand source of single propagating microwaves photons. Working in the context of a quantum network, nodes are connected via propagating, nonclassical states of the electromagnetic field. As such, preparing and detecting propagating quantum states is an essential task. I work with one particular node consisting of a microfabricated, effective two level system coupled to a microwave resonator and study its ability to produce propagating nonclassical states, such as single photon states. In principle, states generated by this node could be sent to other such nodes. However, I send them into a Josephson parametric amplifier (JPA) to characterize the source.
In particular, I discuss how to design and couple the two components that form my source: a fixed frequency transmon qubit and a 3D superconducting waveguide cavity. I demonstrate the ability to control of the dynamics of this combined system and implement a single photon generation protocol, which utilizes a single microwave control field that is far detuned from the photon emission frequency. To characterize the generation, I perform tomography on the propagating photon state to determine its density matrix Ï. I perform repeated JPA-backed, linear measurements of the propagating state. Based on the histograms of my measurements, I infer a maximum single photon component Ï11 = 0:36 ± 0:01. I characterize the imperfections of the photon generation and detection, including detection inefficiency and measurement backaction. I find that within uncertainty my measurements match my expectation