ホウシュツ ショウガイ ニツイテ

Eruption disturbance indicates abnormal eruption of a tooth due to a specific reason. These disturbances are classified on the basis of abnormal eruption time (retarded eruption), quantity (infraoccluded deciduous teeth, impacted tooth), or direction (ectopic eruption). In pediatric dentistry, the frequency of involvement of maxillary incisors is the highest, followed by maxillary canines. Causes of eruption disturbance consist of general and local factors. Examples of general factors are cleidocranial dysostosis, osteopetrosis, hypothyroidism, rickets, and Down syndrome, and those of local factors are apical periodontitis, supernumerary teeth, odontoma, fused primary maxillary incisors, thickened gingival tissue, cyst, prolonged retention, and dental ankylosis. Eruption disturbance is suspected if eruption or exchange is delayed compared with the identical contralateral tooth. This is also applicable in radiographic examination. Treatment options include removal of the cause, creating space for eruption, fenestration, and traction. It is important that eruption disturbance is detected at an early stage and treated at the optimal time

Investigation of factors that high school student's Internet use on parent-child relationship − Investigation of factors that affect self control −

We analyzed the Internet use of high school student’s smartphone by focusing on the difference between self-inhibition evaluation of students and parents.In this study, self-control evaluation on children’s smartphone of parents is different from “ 4 ”of hours and times of net use increased compared to when entering high school，“time spent talking with the family decreased”，“time to study decreased”，“feeling depressed and depressed” It became clear that the item is related. In smartphone use, it was suggested that there is a difference in the way life changes between parents and children and how to catch self control, which may affect parentage relationship

FOLFIRI Is Tolerable after Subtotal Colectomy – A Patient with Familial Adenomatous Polyposis Who Developed Advanced Rectal Cancer

A 40-year-old female with familial adenomatous polyposis (FAP) had a subtotal colectomy at 16 years of age. At 39 years, she had low anterior resection due to advanced rectal carcinoma. Thereafter, we administrated per os uracil and tegafur for 9 months. Metastatic rectal carcinoma was detected in the liver (S8) by computed tomography (CT). 2-[(18)F]-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) data did not show any other metastasis. This report presents a first case of a patient undergoing subtotal colectomy administered FOLFIRI (CPT-11 180 mg/m2 as a 90-minute infusion on day 1; leucovorin 400 mg/m2 as a 2-hour infusion during CPT-11, immediately followed by 5-FU bolus 400 mg/m2 and 46-hour continuous infusion of 2,400 mg/m2 every 2 weeks). This regimen was administered without grade 3 or 4 of any adverse reaction for 6 months, although there was a possibility that this patient with subtotal colectomy may have the cause for severe diarrhea. Further investigations are needed to assess the safety in clinical trials of FOLFIRI regimen for patients with subtotal colectomy

Effect of Salivation by Facial Somatosensory Stimuli of Facial Massage and Vibrotactile Apparatus

We studied the effects of salivary promotion of fluid secretion after hand massage, and the apparatus of vibrotactile stimulation (89 Hz frequency, 15 min) in normal humans. Personal massage cannot be performed on handicap and stroke patients, and then giving hand massage to them for 5 min massage gives a tired feeling. So, we focused 3 min stranger massage. Salivary glands can discharge the accumulated saliva by extrusion from the acinus glands’ massages as described in the recent Japanese textbook. We think that this method may not produce realistic recovery. Our aim ideas are to relieve stress and increase temperature with lightly touch massage of the skin and for a 1 cycle of 1 s. We recorded RR interval of ECG, total salivation, facial skin temperature, OxyHb of fNIRS on the frontal cortex, and amylase activity for the autonomic changes. In increased 2°C of the facial skin temperature, the hand massage had a need for 3 min and the vibrotactile stimulation for 15 min. Increase from 700 to 1000 ms of RR intervals had a need for 3 min in the hand massage and had 15 min in the vibrotactile stimulation. Although vibrotactile stimulation needs long time of 4–7 years as effective recovery, hand massage may have more effect with a repetition of day after day

FGF2 SUPPRESSED CCL11 EXPRESSION IN HUMAN DENTAL PULP-DERIVED MSCs

The regulation of the mesenchymal stem cell (MSC) programming mechanism promises great success in regenerative medicine. Tissue regeneration has been associated not only with the differentiation of MSCs, but also with the microenvironment of the stem cell niche that involves various cytokines and immune cells in the tissue regeneration site. In the present study, fibroblast growth factor 2 (FGF2), the principal growth factor for tooth development, dental pulp homeostasis and dentin repair, was reported to affect the expression of cytokines in human dental pulp‑derived MSCs. FGF2 significantly inhibited the expression of chemokine C‑C motif ligand 11 (CCL11) in a time‑ and dose‑dependent manner in the SDP11 human dental pulp‑derived MSC line. This inhibition was diminished following treatment with the AZD4547 FGF receptor (FGFR) inhibitor, indicating that FGF2 negatively regulated the expression of CCL11 in SDP11 cells. Furthermore, FGF2 activated the phosphorylation of p38 mitogen‑activated protein kinase (p38 MAPK), extracellular signal‑regulated kinase 1/2 (ERK1/2) and c‑Jun N‑terminal kinases (JNK) in SDP11 cells. The mechanism of the FGFR‑downstream signaling pathway was then studied using the SB203580, U0126 and SP600125 inhibitors for p38 MAPK, ERK1/2, and JNK, respectively. Interestingly, only treatment with SP600125 blocked the FGF2‑mediated suppression of CCL11. The present results suggested that FGF2 regulated the expression of cytokines and suppressed the expression of CCL11 via the JNK signaling pathway in human dental pulp‑derived MSCs. The present findings could provide important insights into the association of FGF2 and CCL11 in dental tissue regeneration therapy

和装関連書籍に見る和装品メンテナンスの知識の継承とその問題点 : 最近(1954年～2005年)の雑誌関連記事の記述量と内容から

This article discusses the generation gap as regards the transmission of knowhow concerning the maintenance and cleaning of garments and accessories, especially traditional Japanese kimonos, and reformed kimonos. As in modern day-to-day family life, parent and child do not seem to lose much time on the subject, we concentrated on the transmission of knowhow through the channel of literary sources, i.e. books and magazines. During the years 1954-2005, we picked up 35 books at random and examined the number of pages dedicated to the cleaning and maintenance of kimonos. We found out that the percentage of these pages compared to the total number of pages in books concerning cleaning arrived at a mere 2,8%; even including instructions how to fold and store the kimono only 4,6%. Around 2002, we perceived a dramatic change in the younger generation\u27s perception of the kimono as a fashionable item, as opposed to the cooler, detached reception of the older generation. The instructions of the 1950\u27s explaining how to unsew a kimono disappear; and instead appear around 2000 helpful advice how to avoid soiling a kimono in the first place, and then to bring soiled kimonos to a kimono laundry, if unsure

Salivary Effects of Facial Vibrotactile Stimulation in Patients with Sjogren’s Syndrome and Poor Salivation

We examined the effect of vibrotactile apparatus in patients with Sjögren’s syndrome and others with reduced salivation in comparison to normal subjects. The most effective salivation in normal subjects was produced by 89 Hz vibrotactile stimulation with 9.8 μm amplitude on the parotid or submandibular glands vibrotactile stimuli. First, we examined by measuring the weight of dental cotton rolls positioned at the opening of the secretory duct for total salivation 3 min during resting, and then after 5-min intervals, the weights were measured every 3 min of vibrotactile stimulation on salivary glands. Furthermore, we measured facial temperature around vibrators after 2 min of vibration. We investigated 10 poor salivation patients with Sjögren’s syndrome (8 patients) defined by examinations (contrast study or scintigraphic test) and others (2 patients). About 50% of patients with poor salivation gained recognition for good results, although they had periods of short-term (3 months) and long-term effects (6–7 years) during recuperation. Furthermore, facial skin temperatures on both sides of parotid glands were decreased in Sjogren’s syndrome after vibration, although their temperatures were increased following recovery. Although the mechanism is not clear, we think that vibrotactile stimulation gives activation to salivary glands under the rising facial temperature