Fischer DJ

Harumi Hotta

Hiromu Murofushi

Hiroshi Ueda

Inoue M

Jun Nagai

Kimiko Murakami-Murofushi

Ma L

Mari Gotoh

Murakami-Murofushi K

Tomoyo Ogawa

Ueda H

Yasutaka Kakiuchi

Molecular Pain

English

PubMed

Springer - Publisher Connector

Antinociceptive Effect of Cyclic Phosphatidic Acid and Its Derivative on Animal Models of Acute and Chronic Pain

Background: Cyclic phosphatidic acid (cPA) is a structural analog of lysophosphatidic acid (LPA), but possesses different biological functions, such as the inhibition of autotaxin (ATX), an LPA-synthesizing enzyme. As LPA is a signaling molecule involved in nociception in the peripheral and central systems, cPA is expected to possess analgesic activity. We characterized the effects of cPA and 2-carba-cPA (2ccPA), a chemically stable cPA analog, on acute and chronic pain. Results: (1) The systemic injection of 2ccPA significantly inhibited somato-cardiac and somato-somatic C-reflexes but not the corresponding A-reflexes in anesthetized rats. (2) 2ccPA reduced sensitivity measured as the paw withdrawal response to electrical stimulation applied to the hind paws of mice through the C-fiber, but not Aδ or Aβ. (3) In mice, pretreatment with 2ccPA dose-dependently inhibited the second phase of formalin-induced licking and biting responses. (4) In mice, pretreatment and repeated post-treatments with 2ccPA significantly attenuated thermal hyperalgesia and mechanical allodynia following partial ligation of the sciatic nerve. (5) In rats, repeated post-treatments with 2ccPA also significantly attenuated thermal hyperalgesia and mechanical allodynia following chronic sciatic nerve constriction. Conclusions: Our results suggest that cPA and its stable analog 2ccPA inhibit chronic and acute inflammation-induced C-fiber stimulation, and that the central effects of 2ccPA following repeated treatments attenuate neuropathic pain. </jats:sec

Crossref

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in

Attenuation by cyclic phosphatidic acid of peritoneal metastasis of azoxymethane-induced intestinal cancers in Wistar rats.

Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain.

Baroreflex sensitivity and heart-rate variability in insulin-dependent diabetics with polyneuropathy.

Biological functions of a novel lipid mediator, cyclic phosphatidic acid. Biochim Biophys Acta.

Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis.

Comparison of the antinociceptive effects of preand posttreatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat.

Cyclic phosphatidic acid - a unique bioactive phospholipid.

Cyclic phosphatidic acid stimulates respiration without producing vasopressor or tachycardiac effects in rats.

Evaluation of the tail formalin test in mice as a new model to assess local analgesic effects. Brain Res.

Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain.

Formalin induces biphasic activity in Cfibers in the rat.

Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin.

Inhibition of eukaryotic DNA polymerase alpha with a novel lysophosphatidic acid (PHYLPA) isolated from myxoamoebae of Physarum polycephalum.

Inhibition of paclitaxelinduced A-fiber hypersensitization by gabapentin.

Inhibition of transcellular tumor cell migration and metastasis by novel carba-derivatives of cyclic phosphatidic acid. Biochim Biophys Acta.

Inhibition of tumor invasion and metastasis by a novel lysophosphatidic acid (cyclic LPA).

Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling.

Intrathecal morphine in mice: a new technique.

LG Eltherington, Chapter 2 “Anesthetic Doses”. Drug dosage in laboratory animals: a handbook. 15

Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain. Mol Pain.

Lysophosphatidic acid-induced, pertussis toxin-sensitive nociception through a substance P release from peripheral nerve endings in mice.

Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms. Pharmacol Ther.

Naturally occurring analogs of lysophosphatidic acid elicit different cellular responses through selective activation of multiple receptor subtypes. Mol Pharmacol.

Neuroselective current perception threshold quantitative sensory test.

Novel expression of vanilloid receptor 1 on capsaicin-insensitive fibers accounts Kakiuchi et al.

Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates.

Perineural resiniferatoxin prevents the development of hyperalgesia produced by loose ligation of the sciatic nerve in rats.

Peripheral mechanisms of neuropathic pain - involvement of lysophosphatidic acid receptor-mediated demyelination.

Social modulation of pain as evidence for empathy in mice.

Synthesis of 1-O-acyiglycerol 2,3-cyclic phosphate: determination of the absolute structure of PHYLPA, a specific inhibitor of DNA polymerase α. Tetrahedron Lenten.

Two pathways for lysophosphatidic acid production.

Vzg-1/lysophosphatidic acid-receptor involved in peripheral pain transmission. Brain Res Mol Brain Res.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3113318

Antinociceptive effect of cyclic phosphatidic acid and its derivative on animal models of acute and chronic pain

Antinociceptive effect of cyclic phosphatidic acid and its derivative on animal models of acute and chronic pain

Abstract

Similar works

Full text

Available Versions

Springer - Publisher Connector

Crossref