Quasi-experimental Effectiveness of Cognitive-Behavioral Therapy on Reliving Migraine Headaches in Migraine Sufferers

AbstractObjectives: This study aimed to investigate the effectiveness of cognitive-behavioral therapy on relieving migraine headaches in migraine sufferers.Materials & Methods: The research was a quasi-experimental study with pre-test and post-test method. The samples were outpatients of Public hospitals in Ilam since May - July 2010. They were selected based on inclusion and exclusion criteria, and divided into experimental group and control group. The data were analyzed using SPSS 16. and via multivariate covariance method..Results: The results showed that cognitive-behavioral therapy affected on reducing the duration of symptoms of migraine in sufferers (P<0.05).Conclusion:Cognitive behavioral therapy effects on reducing the time duration of symptoms of migraine headaches. This therapeutic method increases the level of individual, familial, social and occupational activities by reducing the time duration of symptoms and this method helps the individuals to resume their activities and regain their previous control instead of founding themselves incapable and helpless due to the pain they suffer from.

Mechanical Properties of 3D Printed Reinforced Polycaprolactone Composite Scaffolds

Objectives This paper describes the fabrication of a new porous 3D-printed scaffold composed of polycaprolactone (PCL) and polyether-ether ketone (PEEK) micro-particles for bone tissue engineering (BTE) applications. Methods In order to improve the compatibility of the reinforcing PEEK powder with polycaprolactone, the PEEK powder was surface-modified by an amino-silane coupling agent. After modification, Fourier-transform infrared spectrometry (FTIR) and differential scanning calorimetry (DSC) were used to investigate the chemical reaction between PEEK and silane coupling agent. In order to increase the compressive modulus of the 3D printed PCL scaffold, 10% silane-modified PEEK was incorporated into the PCL polymeric matrix. Scanning electron microscopy (SEM) was used for cell morphology and attachment evaluation. Results The results indicated that the silane coupling agent was successfully grafted onto the particle surface. The compressive modulus of PCL scaffold increased by incorporating the silane-modified PEEK, despite having higher porosity, compared with the pure PCL scaffolds. Addition of amino-silane had a positive impact on cell response, and that surface modification led to improved particle dispersion. Conclusion In conclusion, it seems that the incorporation of surface-modified PEEK micro-particles into the PCL porous scaffold could enhance its mechanical properties, and may be applicable for the management of large bone defects

Serum Interleukin-27 Level in Different Clinical Stages of Lung Cancer

BACKGROUND: Advanced lung cancer is indicated with rapid disease development. Interleukin 27 (IL-27) is regarded as a cytokine with anti-tumour activities. AIM: Since, the impact of type of lung cancer on the level of IL-27 in patient’s serum has not yet been investigated; current study evaluated the clinical stages according to American Joint Committee on Cancer (AJCC) criteria, Tumor-Node-Metastasis (TNM) stage and the lung cancer spread (localized or widespread) and it's correlation with serum IL-27. MATERIAL AND METHODS: Thirty patients with confirmed histopathological lung cancer and 30 cancer-free healthy individuals as the control group were included in the current study. Patients group were assigned to either small cell lung cancer group (SCLC) or non-small cell lung cancer (NSCLC) according to the clinical features and the results of lung biopsy specimens. Level of IL-27 was quantified with enzyme-linked immunosorbent assay (ELISA) test in serum samples. RESULTS: A significant increase in serum IL-27 level was noticed in individuals with lung cancer in comparison with the control group. The level of serum IL-27 in the NSCL squamous carcinoma (NSCLC-Sc) type was significantly greater than in the NSCLC adenocarcinoma (NSCLC-Ad) type, and in both groups, this variable was more than the control group. The serum IL-27 content level was greater in stage III versus stage IV. CONCLUSION: The current research confirmed the existence of the anti-tumour components in patients with NSCLC. IL-27 can be utilised in diagnosis and screening in early stages of lung cancer along with the management of patients. Different levels of IL-27 in different types of lung cancers in the current study can lead to design more comprehensive studies in the future

Investigating the prevalence of psychological disorders among children with diabetes aged 5-12 years old referring to Endocrinology clinic of Mofid Hospital in 2014-2015

As there were a few studies about the mental disorders resulting from diabetes in children, this study aimed at investigating the prevalence of psychological disorders among children.the studied samples included 323 children with diabetes type 1 aged 5-12 years old referring to Endocrinology clinic of Mofid Hospital in 2014-2015. Also, 317 healthy children were considered as control group. The materials used for data analysis were information form and questionnaire CSI-4 filled out by their parents. The filled questionnaires were rated in that day and then analyzed and diagnosed by the Pediatric Psychiatry in order to determine the type and intensity of psychological disorder. Results were analyzed using SPSS 20. T tests, Scheffe post hoc test and Pearson’s correlation test were used for analysis of data. The amounts were significantly different at P<0.05.In terms of Neuro-Evolutionary disorders, Attention-deficit (ADD), hyperactivity (HD) and Attention-deficit hyperactivity disorders (ADHD) in children with diabetes were significantly higher than those in healthy children (P=0.001). Intense/ fundamental Depressive disorders were higher in diabetic children (P=0.001). In terms of anxiety disorder, a specific phobia and panic was significantly higher in diabetic children (P=0.005). In terms of aggressive behaviors, diabetic children were more disobedient and stubborn than the others.this study showed that prevalence of psychological disorders among diabetic children was higher than the others. As psychological disorders will effect on the life quality of children, improvement of life quality of diabetic children and adolescents, on-time diagnosis and treatment of psychological disorders in these patients seems essentia

Enterobacter Meningitis Due To Dermoid Cyst Manipulation: A Case Report

Gram-negative meningitis has been reported owing to dura-arachnoid barrier disruption. It can be occurred because of trauma, surgery and rarely infected dermoid cyst. In the 1940, for the first time, the association of neurosurgical procedures and meningitis due to gram-negative bacillary was described.Enterobacter is a serious infection with difficult treatment secondary to inability of many antibiotics to reach to adequate concentration in cerebrospinal fluid.Here in, we report a case of pediatric Enterobactermeningitis in a patient with manipulated dermoid cyst.She was cured with antibiotic therapy and surgery

Evaluation of Biofilm Formation Among Klebsiella pneumoniae Isolates and Molecular Characterization by ERIC-PCR

AbstractBackground: Klebsiella pneumoniae is among the most frequently recovered etiologic agents from nosocomial infections. Thisopportunistic pathogen can generate a thick layer of biofilm as one of its important virulence factors, enabling the bacteria to attach toliving or abiotic surfaces, which contributes to drug resistance. Objectives: The resistance of biofilm-mediated infections to effective chemotherapy has adverse effects on patient outcomes and survival.Therefore, the aim of the present study was to evaluate the biofilm-formation capacity of clinical K. pneumoniae isolates and to perform amolecular characterization using enterobacterial repetitive intergenic consensus-polymerase chain reaction (ERIC-PCR) to determine thedominant biofilm-producing genotype. Patients and Methods: In the present study, 94 K. pneumoniae isolates were obtained from two hospitals in Tehran, Iran. Biofilm formationwas assayed by a modified procedure, then ERIC-PCR was carried out. Results: The distributions of the clinical specimens used in this study were 61.7% from urine, 18.1% from wounds, 11.7% from sputum, and8.5% from blood. Among these isolates, 33% formed fully established biofilms, 52.1% were categorized as moderately biofilm-producing,8.5% formed weak biofilms, and 6.4% were non-biofilm-producers. Genotyping of K. pneumoniae revealed 31 different ERIC types. Biofilmformationability in a special ERIC type was not observed. Conclusions: Our results indicated that an enormous proportion of K. pneumoniae isolated from sputum and surgical-wound swabsproduced fully established biofilms. It is reasonable to assume the existence of a relationship between the site of infection and theformation of biofilm. A high level of genetic diversity among the K. pneumoniae strains was observed

Dietary acid load, depression, and anxiety: results of a population-based study

Abstract Background Dietary acid load seems to be associated with psychological disorders through several mechanisms, and may barricade their treatment and recovery. The aim of current study was to evaluate the relationship between dietary acid load, using potential renal acid load (PRAL) and dietary acid load (DAL) scores, with the severity of depression and anxiety among Iranian adults. Methods A total of 6531 participants aged 35–65 years were recruited in this cross-sectional study. A validated food frequency questionnaire (FFQ) was used to assess dietary intakes of participants. DAL was estimated using PRAL and DAL scores. Depression and anxiety were screened using Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Results In the fully adjusted model, women with the highest DAL or PRAL had higher odds of more severe depression compared to those in the lowest category (OR = 1.20; 95% CI = 1.03–1.42 and OR = 1.20; 95% CI = 1.03–1.39, respectively). No significant association was observed between DAL and PRAL and depression severity in men and in the population as a whole. Regarding the association between PRAL and anxiety severity, there was no significant association when separated by sex. However, in the fully adjusted model for the whole population, participants in the highest tertile of PRAL had 13% greater odds of more severe anxiety than the lowest tertile (OR: 1.13, 95% CI: 1.01–1.13). No significant association was observed between DAL and anxiety severity in women, men or in the whole population. Conclusion Women, but not men, with higher dietary acid load had significantly higher odds of having more severe depression. A significant positive association was also observed between dietary acid load and anxiety in the whole population