Phenotypic and Genetic Relationships between Kidney Function and Carotid Intima-Media Thickness in Koreans: The Healthy Twin Study

Background: The phenotypic and genetic relationships between carotid intima-media thickness (CIMT) and estimated glomerular filtration rate (eGFR) or urinary albumin-creatinine ratio (ACR) were evaluated in Korean twins and families. Methods: We recruited 688 participants (296 individual twins and 392 singletons, age 30-74 years) who were without myocardial infarction and stroke among participants in the Healthy Twin Study. eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. CIMT was measured using B-mode carotid ultrasound. Covariates were sex, Framingham risk scores, alcohol use, exercise, BMI, high-sensitivity C-reactive protein and triglycerides. Quantitative genetic and linear mixed analyses were performed. Results: In adjusted models there were associations between kidney function and CIMT with [beta] estimates ranging from -0.022 to -0.032 between eGFR and CIMT, and from 0.042-0.060 between ACR and CIMT. The covariate-adjusted heritabilities for eGFR, ACR and composite CIMT were 0.75, 0.32 and 0.45, respectively (p < 0.001). The adjusted genetic correlation between eGFR and CIMT was from -0.20 to -0.28 (p < 0.05), whereas there was no genetic correlation between ACR and CIMT. Conclusion: Kidney function is a surrogate marker of carotid atherosclerosis and further studies of the pleiotropic relationships between CIMT and eGFR are warranted. Copyright (C) 2012 S. Karger AG, BaselOAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000040632/16SEQ:16PERF_CD:SNU2012-01EVAL_ITEM_CD:102USER_ID:0000040632ADJUST_YN:YEMP_ID:A077602DEPT_CD:902CITE_RATE:1.596FILENAME:phenotypic and genetic relationships between kidney function and carotid intima-media thickness in koreans the healthy twin study.pdfDEPT_NM:보건학과SCOPUS_YN:YCONFIRM:

Кераміка «terra sigillata» з с. Зимне на Волині

Стаття присвячена публікації чотирьох керамічних посудин типу «terra sigillata», знайдених на дні р. Луги у с. Зимне Володимир-Волинського району Волинської області. Попередній аналіз цих знахідок дозволяє віднести їх до Понтійського центру виробництва такого посуду. Вірогідним шляхом потрапляння цієї колекції на Волинь була готська експансія у Північне Причорномор’я

Treatment of ankylosed mandibular first permanent molar

This report describes the treatment of a 21-year old patient with an ankylosed mandibular right first permanent molar. The tooth was noticeably infraoccluded when the patient was first seen, at age 9. Over the next 11 years, several interventions, as well as periods of observation, were undertaken to bring the infraoccluded tooth into occlusion. This was finally accomplished by using a microscrew implant. The final treatment and the treatment procedures during the adolescent period are reported here

Analysis on the Accuracy of Intraoral Scanners: The Effects of Mandibular Anterior Interdental Space

In this study, we evaluated the effects of mandibular anterior interdental space on the accuracy of intraoral scanners. Four models of mandibular arch with varying distances of anterior interdental space were analyzed; incisors were evenly spaced out between the two canines by 0 mm, 1 mm, 3 mm, and 5 mm. The full arch of each model was scanned 10 times with iTero® and Trios®. The images were superimposed with those from the reference scanner (Sensable S3) and compared using Geomagic Verify. Statistical analysis was conducted using a t-test, paired t-test, and one-way analysis of variance (ANOVA). Differences in the accuracy of images were statistically significant according to both iTero® and Trios®; a greater deviation was noted with increasing anterior interdental space (p &lt; 0.05). Upon dividing the lower arch into five sections, larger deviation was observed with iTero® in the molar area, except in the model with 1 mm space. With Trios®, the largest deviation was observed in the right molar area in all models. The maximum deviations of intermolar width were 0.66 mm and 0.76 mm in iTero® and Trios®, respectively. This comparison suggests that Trios® demonstrates a higher accuracy than iTero® in all models and in all sections of the arch. However, the mean deviations indicate that both iTero® and Trios® are clinically acceptable

Impact of Orthodontic Brackets on the Intraoral Scan Data Accuracy

This study aims to compare the impact of buccal and lingual brackets on the accuracy of dental arch data acquired by 4 different digital intraoral scanners. Two pairs of dental casts, one with buccal brackets and the other with lingual brackets, were used. Digital measurements of the 3D images were compared to the actual measurements of the dental models, which were considered standard values. The horizontal measurements included intercanine widths and intermolar widths. The Mann–Whitney U test was performed for comparisons. iTero® and Trios® both showed high accuracy with relatively small maximum deviation of measurements. iTero showed a significantly higher accuracy in most of the arch width measurements on the buccal bracket model than on the lingual model (P<0.05). Zfx IntraScan® and E4D Dentist® produced maximum deviations of more than 2 mm from both the buccal and the lingual bracket models. After comparing the degree of distortion of the arch on the digital scans with actual measurements of the same models, iTero and Trios proved to be excellent in terms of trueness and precision. Nevertheless, digital intraoral scanners should be used more cautiously in arches with lingual brackets than in those with buccal brackets

Change in left inferior frontal connectivity with less unexpected harmonic cadence by musical expertise.

In terms of harmonic expectancy, compared to an expected dominant-to-tonic and an unexpected dominant-to-supertonic, a dominant-to-submediant is a less unexpected cadence, the perception of which may depend on the subject's musical expertise. The present study investigated how aforementioned 3 different cadences are processed in the networks of bilateral inferior frontal gyri (IFGs) and superior temporal gyri (STGs) with magnetoencephalography. We compared the correct rate and brain connectivity in 9 music-majors (mean age, 23.5 ± 3.4 years; musical training period, 18.7 ± 4.0 years) and 10 non-music-majors (mean age, 25.2 ± 2.6 years; musical training period, 4.2 ± 1.5 years). For the brain connectivity, we computed the summation of partial directed coherence (PDC) values for inflows/outflows to/from each area (sPDCi/sPDCo) in bilateral IFGs and STGs. In the behavioral responses, music-majors were better than non-music-majors for all 3 cadences (p < 0.05). However, sPDCi/sPDCo was prominent only for the dominant-to-submediant in the left IFG. The sPDCi was more strongly enhanced in music-majors than in non-music-majors (p = 0.002, Bonferroni corrected), while the sPDCo was vice versa (p = 0.005, Bonferroni corrected). Our data show that music-majors, with higher musical expertise, are better in identifying a less unexpected cadence than non-music-majors, with connectivity changes centered on the left IFG

Increased fronto-temporal connectivity by modified melody in real music.

In real music, the original melody may appear intact, with little elaboration only, or significantly modified. Since a melody is most easily perceived in music, hearing significantly modified melody may change a brain connectivity. Mozart KV 265 is comprised of a theme with an original melody of "Twinkle Twinkle Little Star" and its significant variations. We studied whether effective connectivity changes with significantly modified melody, between bilateral inferior frontal gyri (IFGs) and Heschl's gyri (HGs) using magnetoencephalography (MEG). Among the 12 connectivities, the connectivity from the left IFG to the right HG was consistently increased with significantly modified melody compared to the original melody in 2 separate sets of the same rhythmic pattern with different melody (p = 0.005 and 0.034, Bonferroni corrected). Our findings show that the modification of an original melody in a real music changes the brain connectivity

Changes in views on digital intraoral scanners among dental hygienists after training in digital impression taking

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Abstract Backgrounds Despite the rapid development of digital dentistry, the use of digital intraoral scanners remains limited. The aim of this study was to evaluate the changes in views on intraoral scanners among dental hygienists after training. Methods Thirty-four dental hygienists with >3 years of clinical experience participated and were divided into 2 groups : iTero and Trios groups. Participants of each group practiced the usage of both intraoral scanners, for total 12 times over 4 sessions, Questionnaires were given to participants at two different times; prior to and after the completion of the training sessions. The parameters of questionnaires included on difficulty of use, patient discomfort, awareness, preference, and clinical usefulness of intraoral scanners and comparison of two types of scanners. Results Upon the completion of the training, both iTero and Trios groups gave positive feedback on anticipated accuracy, efficiency, and clinical usefulness. More participants of the iTero group responded that the level of difficulty of use and patient discomfort was greater than Trios. Both groups preferred Trios for its clinical usefulness. Conclusions The perceptions of dental hygienists on usage of intraoral scanner and digital impression improved positively with the training. The participants favored Trios over iTero in terms of difficulty of use , patient comfort, and clinical usefulness. This study showed that appropriate training could change the views on the efficiency of intraoral scanners positively among dental hygienists

In vivo tumor extracellular vesicles promote angiogenesis via macrophage

2