Scalar Field Contribution to Rotating Black Hole Entropy

Scalar field contribution to entropy is studied in arbitrary D dimensional one parameter rotating spacetime by semiclassical method. By introducing the zenithal angle dependent cutoff parameter, the generalized area law is derived. The non-rotating limit can be taken smoothly and it yields known results. The derived area law is then applied to the Banados-Teitelboim-Zanelli (BTZ) black hole in (2+1) dimension and the Kerr-Newman black hole in (3+1) dimension. The generalized area law is reconfirmed by the Euclidean path integral method for the quantized scalar field. The scalar field mass contribution is discussed briefly.Comment: 26 page

Adiabatic Invariant Treatment of a Collapsing Sphere of Quantized Dust

The semiclassical collapse of a sphere of quantized dust is studied. A Born-Oppenheimer decomposition is performed for the wave function of the system and the semiclassical limit is considered for the gravitational part. The method of adiabatic invariants for time dependent Hamiltonians is then employed to find (approximate) solutions to the quantum dust equations of motions. This allows us to obtain corrections to the adiabatic approximation of the dust states associated with the time evolution of the metric. The diverse non-adiabatic corrections are generally associated with particle (dust) creation and related fluctuations. The back-reaction due to the dominant contribution to particle creation is estimated and seen to slow-down the collapse.Comment: LaTeX, 16 pages, no figures, final version to appear in Class. and Quantum Gravit

Urinary trace metals, maternal circulating angiogenic biomarkers, and preeclampsia: a single-contaminant and mixture-based approach

Abstract Background Exposures to toxic metals and deficiencies in essential metals disrupt placentation and may contribute to preeclampsia. However, effects of exposure to combinations of metals remain unknown. Objective We investigated the relationship between urinary trace metals, circulating angiogenic biomarkers, and preeclampsia using the LIFECODES birth cohort. Methods Urine samples collected during pregnancy were analyzed for 17 trace metals and plasma samples were analyzed for soluble fms-like tyrosine-1 (sFlt-1) and placental growth factor (PlGF). Cox proportional hazard models were used to estimate the hazard ratios (HR) of preeclampsia associated with urinary trace metals. Linear regression models were used to estimate the relationship between urinary trace metals and angiogenic biomarkers. Principal components analysis (PCA) was used to identify groups of metals and interactions between principal components (PCs) loaded by toxic and essential metals were examined. Results In single-contaminant models, several toxic and essential metals were associated with lower PlGF and higher sFlt-1/PlGF ratio. Detection of urinary chromium was associated with preeclampsia: HR (95% Confidence Interval [CI]) = 3.48 (1.02, 11.8) and an IQR-increase in urinary selenium was associated with reduced risk of preeclampsia (HR: 0.28, 95% CI: 0.08, 0.94). Using PCA, 3 PCs were identified, characterized by essential metals (PC1), toxic metals (PC2), and seafood-associated metals (PC3). PC1 and PC2 were associated with lower PlGF levels, but not preeclampsia risk in the overall cohort. Conclusions Trace urinary metals may be associated with adverse profiles of angiogenic biomarkers and preeclampsia.https://deepblue.lib.umich.edu/bitstream/2027.42/152235/1/12940_2019_Article_503.pd

Topology and Wilson lines: global aspects of the double copy

The Kerr-Schild double copy relates exact solutions of gauge and gravity theories. In all previous examples, the gravity solution is associated with an abelian-like gauge theory object, which linearises the Yang-Mills equations. This appears to be at odds with the double copy for scattering amplitudes, in which the non-abelian nature of the gauge theory plays a crucial role. Furthermore, it is not yet clear whether or not global properties of classical fields - such as non-trivial topology - can be matched between gauge and gravity theories. In this paper, we clarify these issues by explicitly demonstrating how magnetic monopoles associated with arbitrary gauge groups can be double copied to the same solution (the pure NUT metric) in gravity. We further describe how to match up topological information on both sides of the double copy correspondence, independently of the nature of the gauge group. This information is neatly expressed in terms of Wilson line operators, and we argue through specific examples that they provide a useful bridge between the classical double copy and the BCJ double copy for scattering amplitudes.Comment: 31 pages, 4 figures. Some minor corrections have been implemente

Association of the PHACTR1/EDN1 genetic locus with spontaneous coronary artery dissection

Background: Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of acute coronary syndromes (ACS) afflicting predominantly younger to middle-aged women. Observational studies have reported a high prevalence of extracoronary vascular anomalies, especially fibromuscular dysplasia (FMD) and a low prevalence of coincidental cases of atherosclerosis. PHACTR1/EDN1 is a genetic risk locus for several vascular diseases, including FMD and coronary artery disease, with the putative causal noncoding variant at the rs9349379 locus acting as a potential enhancer for the endothelin-1 (EDN1) gene. Objectives: This study sought to test the association between the rs9349379 genotype and SCAD. Methods: Results from case control studies from France, United Kingdom, United States, and Australia were analyzed to test the association with SCAD risk, including age at first event, pregnancy-associated SCAD (P-SCAD), and recurrent SCAD. Results: The previously reported risk allele for FMD (rs9349379-A) was associated with a higher risk of SCAD in all studies. In a meta-analysis of 1,055 SCAD patients and 7,190 controls, the odds ratio (OR) was 1.67 (95% confidence interval [CI]: 1.50 to 1.86) per copy of rs9349379-A. In a subset of 491 SCAD patients, the OR estimate was found to be higher for the association with SCAD in patients without FMD (OR: 1.89; 95% CI: 1.53 to 2.33) than in SCAD cases with FMD (OR: 1.60; 95% CI: 1.28 to 1.99). There was no effect of genotype on age at first event, P-SCAD, or recurrence. Conclusions: The first genetic risk factor for SCAD was identified in the largest study conducted to date for this condition. This genetic link may contribute to the clinical overlap between SCAD and FMD