Topological Quantum Phase Transition in 5dd Transition Metal Oxide Na2_2IrO3_3

We predict a quantum phase transition from normal to topological insulators in the 5$d$ transition metal oxide Na$_2$IrO$_3$, where the transition can be driven by the change of the long-range hopping and trigonal crystal field terms. From the first-principles-derived tight-binding Hamiltonian we determine the phase boundary through the parity analysis. In addition, our first-principles calculations for Na$_2$IrO$_3$ model structures show that the interlayer distance can be an important parameter for the existence of a three-dimensional strong topological insulator phase. Na$_2$IrO$_3$ is suggested to be a candidate material which can have both a nontrivial topology of bands and strong electron correlations

Exercise training-induced PPARβ increases PGC-1α protein stability and improves insulin-induced glucose uptake in rodent muscles

This study aimed to investigate the long-term effects of training intervention and resting on protein expression and stability of peroxisome proliferator-activated receptor β/δ (PPARβ), peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC1α), glucose transporter type 4 (GLUT4), and mitochondrial proteins, and determine whether glucose homeostasis can be regulated through stable expression of these proteins after training. Rats swam daily for 3, 6, 9, 14, or 28 days, and then allowed to rest for 5 days post-training. Protein and mRNA levels were measured in the skeletal muscles of these rats. PPARβ was overexpressed and knocked down in myotubes in the skeletal muscle to investigate the effects of swimming training on various signaling cascades of PGC-1α transcription, insulin signaling, and glucose uptake. Exercise training (Ext) upregulated PPARβ, PGC-1α, GLUT4, and mitochondrial enzymes, including NADH-ubiquinone oxidoreductase (NUO), cytochrome c oxidase subunit I (COX1), citrate synthase (CS), and cytochrome c (Cyto C) in a time-dependent manner and promoted the protein stability of PPARβ, PGC-1α, GLUT4, NUO, CS, and Cyto C, such that they were significantly upregulated 5 days after training cessation. PPARβ overexpression increased the PGC-1α protein levels post-translation and improved insulin-induced signaling responsiveness and glucose uptake. The present results indicate that Ext promotes the protein stability of key mitochondria enzymes GLUT4, PGC-1α, and PPARβ even after Ext cessation

Renal Podocyte Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin

Hyperglycemia promotes oxidative stress and hence generation of reactive oxygen species (ROS), which is known to play a crucial role in the pathogenesis of diabetic nephropathy. Metformin, an oral hypoglycemic drug, possesses antioxidant effects. The aim of this paper is to investigate the protective effects of metformin on the injury of renal podocytes in spontaneously diabetic Torii (SDT) rats, a new model for nonobese type 2 diabetes. Metformin (350 mg/kg/day) was given to SDT rats for 17 weeks. Blood glucose, glycated haemoglobin (HbA1c), and albuminuria were examined. Kidney histopathology, renal 8-hydroxydeoxyguanosine (8-OHdG) levels and apoptosis were examined. In 43-week-old SDT rats, severe hyperglycemia was developed, and albuminuria was markedly increased. Diabetes induced significant alterations in renal glomerular structure. In addition, urinary and renal 8-OHdG levels were highly increased, and podocyte loss was shown through application of the TUNEL and synaptopodin staining. However, treatment of SDT rats with metformin restored all these renal changes. Our data suggested that diabetes-induced podocyte loss in diabetic nephropathy could be suppressed by the antidiabetes drug, metformin, through the repression of oxidative injury

KIOM-79, an Inhibitor of AGEs–Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats

Advanced glycation end products (AGEs) have been implicated in the development of diabetic complications, including diabetic nephropathy. KIOM-79, an 80% ethanolic extract obtained from parched Puerariae Radix, gingered Magnolia Cortex, Glycyrrhiza Radix and Euphorbia Radix, was investigated for its effects on the development of renal disease in Zucker diabetic fatty rats, an animal model of type 2 diabetes. In vitro inhibitory effect of KIOM-79 on AGEs cross-linking was examined by enzyme-linked immunosorbent assay (ELISA). KIOM-79 (50 mg/kg/day) was given to Zucker diabetic fatty rats for 13 weeks. Body and kidney weight, blood glucose, glycated hemoglobin, urinary albumin and creatinine excretions were monitored. Kidney histopathology, collagen accumulation, fibrinogen and transforming growth factor-beta 1 (TGF-β1) expression were also examined. KIOM-79 reduced blood glucose, kidney weight, histologic renal damage and albuminuria in Zucker diabetic fatty rats. KIOM-79 prevented glomerulosclerosis, tubular degeneration, collagen deposition and podocyte apoptosis. In the renal cortex, TGF-β1, fibronectin mRNA and protein were significantly reduced by KIOM-79 treatment. KIOM-79 reduces AGEs accumulation in vivo, AGE–protein cross-linking and protein oxidation. KIOM-79 could be beneficial in preventing the progression of diabetic glomerularsclerosis in type 2 diabetic rats by attenuating AGEs deposition in the glomeruli

Does the Electronic Medical Record (EMR) Adoption Matter? Exploring Patterns of EMR Implementation and its Impact on Hospital Performance

We aimed to explore the patterns of electronic medical records (EMR) adoption and its effects on hospital performance. We analyzed hospital-level panel data from 2008 to 2013 using Bayesian regression and the Naïve Bayes model. Our research analysis revealed 38 different adoption patterns for 1,919 hospitals that completed EMR implementation (having all of the four components) and 42 different investment patterns for 1,341 hospitals that could not complete the EMR implementation. We examined the hospitals’ EMR adoption patterns that were not completed; but predicted as completed using the Naïve Bayes model. Our results revealed that the hospitals that completed EMR adoption showed higher performance in terms of patient recommendation and net patient revenue than those that did not complete EMR adoption. More importantly, most of hospitals that observed as “not completed” but predicted as “completed” showed lower performance in terms of patient recommendation as well as net patient revenue

Discovery of a rapid, luminous nova in NGC 300 by the KMTNet Supernova Program

We present the discovery of a rapidly evolving transient by the Korean Microlensing Telescope Network Supernova Program (KSP). KSP is a novel high-cadence supernova survey that offers deep ($\sim21.5$ mag in $BVI$ bands) nearly continuous wide-field monitoring for the discovery of early and/or fast optical transients. KSP-OT-201509a, reported here, was discovered on 2015 September 27 during the KSP commissioning run in the direction of the nearby galaxy NGC~300, and stayed above detection limit for $\sim$ 22 days. We use our $BVI$ light-curves to constrain the ascent rate, $-3.7(7)$ mag day$^{-1}$ in $V$, decay time scale, $t^{V}_{2}=1.7(6)$ days, and peak absolute magnitude, $-9.65\leq M_{V}\leq -9.25$ mag. We also find evidence for a short-lived pre-maximum halt in all bands. The peak luminosity and lightcurve evolution make KSP-OT-201509a consistent with a bright, rapidly decaying nova outburst. We discuss constraints on the nature of the progenitor and its environment using archival HST/ACS images and conclude with a broad discussion on the nature of the system.Comment: 7 pages in aastex6 two-column format, 4 figures; accepted in Ap