Upregulation of VEGF and FGF2 in Normal Rat Brain after Experimental Intraoperative Radiation Therapy

The expression of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF)2 in the irradiated brain was examined to test how a single high dose radiation, similar to that used for intraoperative radiation therapy given to the normal cerebrum, can affect the vascular endothelium. After a burr hole trephination in the rat skull, the cerebral hemisphere was exposed to a single 10 Gy dose of gamma rays, and the radiation effect was assessed at 1, 2, 4, 6, and 8 weeks after irradiation. His-tological changes, such as reactive gliosis, inflammation, vascular proliferation and necrosis, were correlated with the duration after irradiation. Significant VEGF and FGF2 expression in the 2- and 8-week were detected by enzyme-linked immunosorbent assay quantification in the radiation group. Immunohistochemical study for VEGF was done and the number of positive cells gradually increased over time, compared with the sham operation group. In conclusion, the radiation injuries consisted of radiation necrosis associated with the expression of VEGF and FGF2. These findings indicate that VEGF and FGF2 may play a role in the radiation injuries after intraoperative single high-dose irradiation

High expression of DEK is associated with poor prognosis in hepatocellular carcinoma.

DEK is an oncogene that has been identified as part of the DEK-CAN fusion gene. DEK plays a role in carcinogenesis through WNT signaling and induces cell proliferation through cyclin-dependent kinase signaling. DEK overexpression has been reported in HCC, but the clinical significance is unclear. This study enrolled 221 cases of HCC. The expression of DEK protein was evaluated by immunohistochemical staining. Cdk4, cyclin D1, Wnt10b, E-cadherin, and β-catenin were also immunohistochemically stained and analyzed for correlation. The association of clinicopathologic factors with DEK expression was analyzed. DEK expression was observed in 44.8% (99/221) of cases. DEK expression showed a statistical association with clinicopathologic factors, including Edmondson-Steiner grade, presence of vascular emboli, and multiplicity (p<0.05). Among the other IHC markers, the expression of cdk4 was correlated with DEK expression (p<0.05). Patients with high DEK expression showed a significantly lower overall survival rate (p=0.006). However, the disease-free survival rate did not differ significantly. In addition, in a Cox regression model analysis, DEK expression was an independent prognostic factor. In summary, high expression of DEK was observed in HCC and was associated with poor prognostic marker expression and poor prognosis

The Korean Journal of Pathology의 SCI-e 및 JCR 등재를 축하합니다

2008년 5월 Thomson & Reuters (Thomson Scientific Co.)는 The Korean Journal of Pathology (Korean J Pathol) 등 9개 한국 학술지를 포함한 157개 학술지를 새롭게 SCI-expanded에 등재하고 3개 학술지를 제외한다고 발표하였다. 2008년 5월 현재 전체 SCI-e 학술지는 모두 7,321개이며 이 중 한국에서 발행되는 학술지는 총 59개이고 그 중 의학 생명과학 분야 학술지는 12개이다. 1967년 창간한 Korean J Pathol은 이번에 SCI-expanded에 등재되면서 국제사회에서 인정받는 유수의 전문학술지가 되었다. 이제부터 우리 학회지에 게재된 논문과 그 논문이 인용한 참고 문헌은 세계의 과학자들이 가장 많이 검색하는 데이터베이스에 포함됨으로써 더 읽히고, 더 인용될 뿐 아니라 더 많은 감시를 받게 된다. 이는 2008년 창간된 Basic and Applied Pathology1 와 더불어 2008년도 대한병리학회 학술 활동의 경사이며, 이에 SCI-e 등재의 의미를 이해하고 발전적인 학회와 학술지 운영에 대하여 생각해 보기로 한다