Domain-mediated interactions for protein subfamily identification

Within a protein family, proteins with the same domain often exhibit different cellular functions, despite the shared evolutionary history and molecular function of the domain. We hypothesized that domain-mediated interactions (DMIs) may categorize a protein family into subfamilies because the diversified functions of a single domain often depend on interacting partners of domains. Here we systematically identified DMI subfamilies, in which proteins share domains with DMI partners, as well as with various functional and physical interaction networks in individual species. In humans, DMI subfamily members are associated with similar diseases, including cancers, and are frequently co-associated with the same diseases. DMI information relates to the functional and evolutionary subdivisions of human kinases. In yeast, DMI subfamilies contain proteins with similar phenotypic outcomes from specific chemical treatments. Therefore, the systematic investigation here provides insights into the diverse functions of subfamilies derived from a protein family with a link-centric approach and suggests a useful resource for annotating the functions and phenotypic outcomes of proteins.11Ysciescopu

Examining the negative relationship between length of stay at a hotel and customer satisfaction: Evidence from online customer reviews

Purpose Studies that investigate the length of stay as a predictor of consumer post-purchase behavior are rare despite its importance in efficient hotel management. By analyzing online customer reviews, this study aims to fill this gap in the extant literature on the relationship between length of stay and customer satisfaction level. Design/methodology/approach The authors collected and used online review data on hotels in London for this study. A series of linear regression analyses were conducted to examine the effect of length of stay on customer satisfaction as measured by review ratings. The authors used the Mahalanobis matching approach to confirm the empirical findings. Findings This analysis shows that length of stay is negatively associated with customer satisfaction. Additionally, the authors find that this negative relationship is stronger in high-end hotels than in low-end hotels. Research limitations/implications The research findings contribute to the literature by shedding light on a new stream of research, namely, length of stay. Additionally, the research findings offer novel insights that could help hotel managers understand the trade-off between longer stays and customer satisfaction. Originality/value To the best of the authors’ knowledge, this is one of the first few studies to show the systematic impact of length of stay on the valence of online review ratings, as well as the moderating effect of hotel levels by analyzing customer online reviews on hotel experiences

Impact of the length of stay at hotels on online reviews

Purpose The length of stay (LoS) is of major importance from the perspective of the management of tourist destinations. As tourists heavily rely on the online reviews of other travelers as a primary information source, this study aims to empirically examine how the LoS can influence the online reviews for hotels, with special emphasis on the textual review content. Design/methodology/approach This study analyzes online review data collected from Booking.com by using the Linguistic Inquiry and Word Count program to operationalize review depth, analytical thinking and the authenticity reflected in customer reviews. Based on the analyzed data, this study used a series of regression analyses to understand the impacts of the LoS on online reviews. Findings The author’s analysis found that a longer stay at a hotel causes consumers to be more likely to post online reviews that not only include a numerical rating as well as written content but also lengthier and more detailed descriptions of their hotel experiences. Further analysis found that the LoS at hotels causes systematic differences in the linguistic attributes of the review content. Specifically, consumers who stay longer tend to write reviews with more analytical information, resulting in consumers perceiving the online reviews as more authentic. Research limitations/implications Although the LoS has been considered a significant issue in tourism, studies examining the impact of different lengths of stay on consumers’ post-purchase behaviors are limited. In this light, the author’s findings demonstrate how the LoS can change the linguistic attributes of online reviews. It expands the body of knowledge of the LoS in tourism. Originality/value This study represents the first attempt to empirically examine and reveal how the different length of stay at a hotel systemically influences consumer review-posting behaviors

The impact of comment history disclosure on online comment posting behaviors

Purpose This study aimed to empirically examine the effectiveness of disclosing user comment history without disclosing personal identity as a nudge policy to refrain users from posting malicious content online. Design/methodology/approach The authors collected the number of comments and posters from the leading portal website in South Korea, Naver.com. To causally investigate the impacts of the new nudge policy on the number of comments and posters, the authors used the regression discontinuity design (RDD) approach. Findings The authors found that the new policy reduced all types of comments, including the number of malicious comments, self-deleted comments and current comments. This resulted in an overall decrease in the total number of posted comments, which is considered a side effect. In addition, the authors found that the effect of the nudge policy, which disclosed user comment history, has a stronger effect on older female users than their counterparts. Originality/value The study findings extend the current knowledge on a nudge policy being implemented by a website as a means to reduce malicious online content and how it impacts user content posting behaviors

Probing TeV scale Top-Philic Resonances with Boosted Top-Tagging at the High Luminosity LHC

We investigate the discovery potential of singly produced top-philic resonances at the high luminosity (HL) LHC in the four-top final state. Our analysis spans over the fully-hadronic, semi-leptonic, and same-sign dilepton channels where we present concrete search strategies adequate to a boosted kinematic regime and high jet-multiplicity environments. We utilize the Template Overlap Method (TOM) with newly developed template observables for tagging boosted top quarks, a large-radius jet variable $M_J$ and customized b-tagging tactics for background discrimination. Our results show that the same-sign dilepton channel gives the best sensitivity among the considered channels, with an improvement of significance up to 10%-20% when combined with boosted-top tagging. Both the fully-hadronic and semi-leptonic channels yield comparable discovery potential and contribute to further enhancements in the sensitivity by combining all channels. Finally, we show the sensitivity of a top-philic resonance at the LHC and HL-LHC by showing the $2\sigma$ exclusion limit and $5\sigma$ discovery reach, including a combination of all three channels.Comment: 19 pages, 14 figure

Boosted Event Topologies from TeV Scale Light Quark Composite Partners

We propose a new search strategy for quark partners which decay into a boosted Higgs and a light quark. As an example, we consider phenomenologically viable right handed up-type quark partners of mass $\sim 1$ TeV in composite pseudo-Nambu-Goldstone-boson Higgs models within the context of flavorful naturalness. Our results show that $S/B > 1$ and signal significance of $\sim 7\sigma$ is achievable at $\sqrt{s} = 14$ TeV LHC with 35 $fb^{-1}$ of integrated luminosity, sufficient to claim discovery of a new particle. A combination of a multi-dimensional boosted Higgs tagging technique, kinematics of pair produced heavy objects and $b$-tagging serves to efficiently diminish the large QCD backgrounds while maintaining adequate levels of signal efficiency. We present the analysis in the context of effective field theory, such that our results can be applied to any future search for pair produced vector-like quarks with decay modes to Higgs and a light jet.Comment: 18 pages, 7 figures, 5 tables, v2: short discussion added in Sec. 2, references added, corresponds to version published in JHE

Prediction of vertical bearing capacity of waveform micropile

This study proposes a predictive equation for bearing capacity considering the behaviour characteristics of a waveform micropile that can enhance the bearing capacity of a conventional micropile. The bearing capacity of the waveform micropile was analysed by a three-dimensional numerical model with soil and pile conditions obtained from the field and centrifuge tests. The load-transfer mechanism of the waveform micropile was revealed by the numerical analyses, and a new predictive equation for the bearing capacity was proposed. The bearing capacities of the waveform micropile calculated by the new equation were comparable with those measured from the field and centrifuge tests. This validated a prediction potential of the new equation for bearing capacity of waveform micropiles

Wigner's Spins, Feynman's Partons, and Their Common Ground

The connection between spin and symmetry was established by Wigner in his 1939 paper on the Poincar\'e group. For a massive particle at rest, the little group is O(3) from which the concept of spin emerges. The little group for a massless particle is isomorphic to the two-dimensional Euclidean group with one rotational and two translational degrees of freedom. The rotational degree corresponds to the helicity, and the translational degrees to the gauge degree of freedom. The question then is whether these two different symmetries can be united. Another hard-pressing problem is Feynman's parton picture which is valid only for hadrons moving with speed close to that of light. While the hadron at rest is believed to be a bound state of quarks, the question arises whether the parton picture is a Lorentz-boosted bound state of quarks. We study these problems within Einstein's framework in which the energy-momentum relations for slow particles and fast particles are two different manifestations one covariant entity.Comment: LaTex 12 pages, 3 figs, based on the lectures delivered at the Advanced Study Institute on Symmetries and Spin (Prague, Czech Republic, July 2001