Structural details of an art gallery

Thesis (M. Arch.)--Massachusetts Institute of Technology, Dept. of Architecture, 1995.Includes bibliographical references (leaves 34-35).Connections describes the physical means by which the building transforms concept into reality. These connections link between user and building; site and building; program and building; art and public. This study uses as a starting point a previous design project where advances technology allowed and informed the complex geometry and overall composition of the building. This thesis investigates the assemblage of the major building components to demonstrate how the connections make the building. This model will show how these technologies best realize the intent of the program. This art gallery gives up-and-coming local and regional artists and designers the opportunity to exhibit their work. The combination of the building and program will increase the interaction between the general public and art. The building design distinguishes itself from the typical temple- or vault-like quality of the art museum and exhibits a more inviting form. These connections not only make the building; they connect art and public in a more dynamic relationship.by Amy M. Kim.M.Arch

Children’s episodic and generic reports of alleged abuse

With the present data, we explored the relations between the language of interviewer questions, children’s reports, and case and child characteristics in forensic interviews. Results clearly indicated that the type of questions posed by interviewers – either probing generic or episodic features of an event – was related to the specificity of information reported by children. Further, interviewers appeared to adjust their questioning strategies based on the frequency of the alleged abuse. Children alleging single instances of abuse were asked more episodic questions than those alleging multiple abuses. In contrast, children alleging multiple incidents of abuse were asked a greater proportion of generic questions. Given that investigators often seek forensically-relevant episodic information, it is recommended that training for investigators focus on recognition of prompt selection tendencies and developing strategies for posing non-suggestive, episodically focused questions

Rabies Surveillance Identifies Potential Risk Corridors and Enables Management Evaluation

Intensive efforts are being made to eliminate the raccoon variant of rabies virus (RABV) from the eastern United States and Canada. The United States Department of Agriculture (USDA) Wildlife Services National Rabies Management Program has implemented enhanced rabies surveillance (ERS) to improve case detection across the extent of the raccoon oral rabies vaccination (ORV) management area. We evaluated ERS and public health surveillance data from 2006 to 2017 in three northeastern USA states using a dynamic occupancy modeling approach. Our objectives were to examine potential risk corridors for RABV incursion from the U.S. into Canada, evaluate the effectiveness of ORV management strategies, and identify surveillance gaps. ORV management has resulted in a decrease in RABV cases over time within vaccination zones (from occupancy (ψ) of 0.60 standard error (SE) = 0.03 in the spring of 2006 to ψ of 0.33 SE = 0.10 in the spring 2017). RABV cases also reduced in the enzootic area (from ψ of 0.60 SE = 0.03 in the spring of 2006 to ψ of 0.45 SE = 0.05 in the spring 2017). Although RABV occurrence was related to habitat type, greater impacts were associated with ORV and trap–vaccinate–release (TVR) campaigns, in addition to seasonal and yearly trends. Reductions in RABV occupancy were more pronounced in areas treated with Ontario Rabies Vaccine Bait (ONRAB) compared to RABORAL V-RG®. Our approach tracked changes in RABV occurrence across space and time, identified risk corridors for potential incursions into Canada, and highlighted surveillance gaps, while evaluating the impacts of management actions. Using this approach, we are able to provide guidance for future RABV management

Predicting spatial spread of rabies in skunk populations using surveillance data reported by the public

Background: Prevention and control of wildlife disease invasions relies on the ability to predict spatio-temporal dynamics and understand the role of factors driving spread rates, such as seasonality and transmission distance. Passive disease surveillance (i.e., case reports by public) is a common method of monitoring emergence of wildlife diseases, but can be challenging to interpret due to spatial biases and limitations in data quantity and quality. Methodology/Principal findings: We obtained passive rabies surveillance data from dead striped skunks (Mephitis mephitis) in an epizootic in northern Colorado, USA. We developed a dynamic patch-occupancy model which predicts spatio-temporal spreading while accounting for heterogeneous sampling. We estimated the distance travelled per transmission event, direction of invasion, rate of spatial spread, and effects of infection density and season. We also estimated mean transmission distance and rates of spatial spread using a phylogeographic approach on a subsample of viral sequences from the same epizootic. Both the occupancy and phylogeographic approaches predicted similar rates of spatio-temporal spread. Estimated mean transmission distances were 2.3 km (95% Highest Posterior Density (HPD95): 0.02, 11.9; phylogeographic) and 3.9 km (95% credible intervals (CI95): 1.4, 11.3; occupancy). Estimated rates of spatial spread in km/year were: 29.8 (HPD95: 20.8, 39.8; phylogeographic, branch velocity, homogenous model), 22.6 (HPD95: 15.3, 29.7; phylogeographic, diffusion rate, homogenous model) and 21.1 (CI95: 16.7, 25.5; occupancy). Initial colonization probability was twice as high in spring relative to fall. Conclusions/Significance: Skunk-to-skunk transmission was primarily local (< 4 km) suggesting that if interventions were needed, they could be applied at the wave front. Slower viral invasions of skunk rabies in western USA compared to a similar epizootic in raccoons in the eastern USA implies host species or landscape factors underlie the dynamics of rabies invasions. Our framework provides a straightforward method for estimating rates of spatial spread of wildlife diseases

Surface Engineering for Phase Change Heat Transfer: A Review

Among numerous challenges to meet the rising global energy demand in a sustainable manner, improving phase change heat transfer has been at the forefront of engineering research for decades. The high heat transfer rates associated with phase change heat transfer are essential to energy and industry applications; but phase change is also inherently associated with poor thermodynamic efficiencies at low heat flux, and violent instabilities at high heat flux. Engineers have tried since the 1930's to fabricate solid surfaces that improve phase change heat transfer. The development of micro and nanotechnologies has made feasible the high-resolution control of surface texture and chemistry over length scales ranging from molecular levels to centimeters. This paper reviews the fabrication techniques available for metallic and silicon-based surfaces, considering sintered and polymeric coatings. The influence of such surfaces in multiphase processes of high practical interest, e.g., boiling, condensation, freezing, and the associated physical phenomena are reviewed. The case is made that while engineers are in principle able to manufacture surfaces with optimum nucleation or thermofluid transport characteristics, more theoretical and experimental efforts are needed to guide the design and cost-effective fabrication of surfaces that not only satisfy the existing technological needs, but also catalyze new discoveries

A Phase I Study of Abiraterone Acetate Combined with BEZ235, a Dual PI3K/mTOR Inhibitor, in Metastatic Castration Resistant Prostate Cancer.

Lessons learnedThe combination of standard dose abiraterone acetate and BEZ235, a pan-class I PI3K and mTORC1/2 inhibitor, was poorly tolerated in men with progressive mCRPC.Although the clinical development of BEZ235 has been discontinued in prostate cancer, agents that more selectively target PI3K-AKT-mTOR signaling may have a more favorable therapeutic index and should continue to be explored.BackgroundAndrogen receptor (AR) and phosphatidylinositol-3 kinase (PI3K) signaling are two commonly perturbed pathways in prostate cancer. Preclinical data have shown that the two pathways compensate for each other when one is inhibited, and combined inhibition of AR and PI3K signaling may be a viable strategy to prevent or overcome castration resistance.MethodsThis phase I study evaluated the safety and tolerability of abiraterone acetate and prednisone combined with BEZ235, a dual PI3K and mTORC1/2 inhibitor, in men with progressive metastatic castration resistant prostate cancer (mCRPC) who have not received prior chemotherapy.ResultsSix patients (n = 6) were treated at the starting dose level of abiraterone acetate 1,000 mg with prednisone 5 mg twice daily and BEZ235 200 mg twice daily in a 3 + 3 dose escalation design. The study was terminated early because three of the six patients (50%) experienced dose-limiting toxicities: grade 3 mucositis, grade 3 hypotension, and grade 4 dyspnea and pneumonitis. All six patients had previously progressed on abiraterone/prednisone. The median treatment duration was 27 days (range: 3-130 days). No prostate-specific antigen (PSA) decline or objective response were observed.ConclusionThe combination of standard-dose abiraterone/prednisone with BEZ235 200 mg twice daily was poorly tolerated in patients with mCRPC. The on-target and off-target effects of dual PI3K and mTORC inhibition likely contributed to the unacceptable toxicity profile. The Oncologist 2017;22:503-e43

Efficiency of different spatial and temporal strategies for reducing vertebrate pest populations

Understanding effectiveness of control strategies of pest species is fundamental for planning efficient and cost-effective management programs. In addition to culling rates, there are many potential factors that can determine efficiency of different management strategies, including demographic processes such as immigration rates, birth dynamics, and spatial ecology. We developed a stochastic, data-based simulation model of feral swine population dynamics which accounted for social dynamics in space. We tested the impacts of different spatio-temporal management strategies (i.e., culling rates, timing of culling during the year, spatial pattern of culling and strength of a barrier to immigration) on population response and efficiency. The spatial culling strategy dramatically impacted efficiency of control – using zonation required removal of fewer pigs (up to 46% less) to achieve similar reductions compared with other spatial strategies. Also, our spatially-explicit model predicted that lower culling intensities could be used to achieve population reductions when zonation was applied relative to predictions from harvesting theory based on simple logistic models. As culling intensity increased (≥50% of target population annually) and the target population reached low density (\u3c5% of original density), effects of spatial strategy became less pronounced relative to immigration barrier effects. Lastly, for the same level of moderate culling effort, prioritization of culling during the low-birthing period generally resulted in faster population reduction to near zero abundance relative to prioritization during the high-birthing period, or spreading the work over a year period, but the significance of this effect depended on the spatial culling strategy and culling intensity. Our results imply that continually updating knowledge of current abundance during management may not only be important for determining culling quotas, but also for updating and optimizing management strategies. When the management goal is maximum population control, consideration of birth and spatial dynamics can increase return on management effort and bring to light management inefficiencies

Healthcare Barriers of Residents at a Subsidized Housing Community

Introduction: Despite expanded healthcare programs, the low income and elderly lack coverage of vision, hearing, and dental services. Community services are often asked to fill these gaps. To evaluate the situation in Burlington, VT, we surveyed staff and residents in Burlington Housing Authority (BHA) subsidized housing to (1) identify gaps in healthcare coverage and (2) assess barriers to accessing those services in this population.https://scholarworks.uvm.edu/comphp_gallery/1207/thumbnail.jp

Rabies Surveillance Identifies Potential Risk Corridors and Enables Management Evaluation

Intensive efforts are being made to eliminate the raccoon variant of rabies virus (RABV) from the eastern United States and Canada. The United States Department of Agriculture (USDA) Wildlife Services National Rabies Management Program has implemented enhanced rabies surveillance (ERS) to improve case detection across the extent of the raccoon oral rabies vaccination (ORV) management area. We evaluated ERS and public health surveillance data from 2006 to 2017 in three northeastern USA states using a dynamic occupancy modeling approach. Our objectives were to examine potential risk corridors for RABV incursion from the U.S. into Canada, evaluate the effectiveness of ORV management strategies, and identify surveillance gaps. ORV management has resulted in a decrease in RABV cases over time within vaccination zones (from occupancy (ψ) of 0.60 standard error (SE) = 0.03 in the spring of 2006 to ψ of 0.33 SE = 0.10 in the spring 2017). RABV cases also reduced in the enzootic area (from ψ of 0.60 SE = 0.03 in the spring of 2006 to ψ of 0.45 SE = 0.05 in the spring 2017). Although RABV occurrence was related to habitat type, greater impacts were associated with ORV and trap–vaccinate–release (TVR) campaigns, in addition to seasonal and yearly trends. Reductions in RABV occupancy were more pronounced in areas treated with Ontario Rabies Vaccine Bait (ONRAB) compared to RABORAL V-RG®. Our approach tracked changes in RABV occurrence across space and time, identified risk corridors for potential incursions into Canada, and highlighted surveillance gaps, while evaluating the impacts of management actions. Using this approach, we are able to provide guidance for future RABV management