61 research outputs found

    Management and outcomes of pregnant ICU patients with severe COVID-19 pneumonia in Qatar: A retrospective cohort study

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    Introduction: Pregnant women are considered a high-risk group for COVID-19 due to their increased vulnerability to viral infections. The impact of COVID-19 on pregnant women is not well understood, and there is a need for data on managing severe COVID-19 in pregnant patients. This retrospective descriptive cohort study described the characteristics, hospital stay, interventions, and outcomes of pregnant patients admitted to the intensive care units (ICUs) with severe COVID-19 pneumonia in Qatar. Methods: Data were collected from medical records and chart reviews of pregnant women admitted to Hamad Medical Corporation (HMC) with COVID-19 pneumonia from March 01, 2020, to July 31, 2021. The inclusion criteria encompassed pregnant women with a positive polymerase chain reaction (PCR) antigen test or radiological changes at admission, requiring respiratory support, and hospitalized for more than 24 hours. Results: A total of 43 pregnant women were included in this study. Most patients were admitted during the first wave of the pandemic, with a median gestational age of 212 days [interquartile range 178–242 days] at presentation. The most common respiratory support methods were high-flow nasal cannula, non-invasive positive pressure ventilation, and invasive positive pressure ventilation. Convalescent plasma therapy was administered to 58% of patients, and tocilizumab was used in 28%. Renal replacement therapy was required by 4.6% of patients and 7% required extracorporeal membrane oxygenation. Conclusion: This study provides valuable insights into the impact of COVID-19 on pregnant patient

    Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour

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    To facilitate smoking genetics research we determined whether a screen of mutagenized zebrafish for nicotine preference could predict loci affecting smoking behaviour. From 30 screened F-3 sibling groups, where each was derived from an individual ethyl-nitrosurea mutagenized F-0 fish, two showed increased or decreased nicotine preference. Out of 25 inactivating mutations carried by the F-3 fish, one in the slit3 gene segregated with increased nicotine preference in heterozygous individuals. Focussed SNP analysis of the human SLIT3 locus in cohorts from UK (n=863) and Finland (n=1715) identified two variants associated with cigarette consumption and likelihood of cessation. Characterisation of slit3 mutant larvae and adult fish revealed decreased sensitivity to the dopaminergic and serotonergic antagonist amisulpride, known to affect startle reflex that is correlated with addiction in humans, and increased htr1aa mRNA expression in mutant larvae. No effect on neuronal pathfinding was detected. These findings reveal a role for SLIT3 in development of pathways affecting responses to nicotine in zebrafish and smoking in humans.Peer reviewe

    Adult zebrafish as a model organism for behavioural genetics

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    Recent research has demonstrated the suitability of adult zebrafish to model some aspects of complex behaviour. Studies of reward behaviour, learning and memory, aggression, anxiety and sleep strongly suggest that conserved regulatory processes underlie behaviour in zebrafish and mammals. The isolation and molecular analysis of zebrafish behavioural mutants is now starting, allowing the identification of novel behavioural control genes. As a result of this, studies of adult zebrafish are now helping to uncover the genetic pathways and neural circuits that control vertebrate behaviour

    Molecular psychiatry of zebrafish

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    Due to their well-characterized neural development and high genetic homology to mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field of biological psychiatry. Here, we discuss the molecular psychiatry of zebrafish, and its implications for translational neuroscience research and modeling central nervous system (CNS) disorders. In particular, we outline recent genetic and technological developments allowing for in vivo examinations, high-throughput screening and whole-brain analyses in larval and adult zebrafish. We also summarize the application of these molecular techniques to the understanding of neuropsychiatric disease, outlining the potential of zebrafish for modeling complex brain disorders, including attention-deficit/hyperactivity disorder (ADHD), aggression, post-traumatic stress and substance abuse. Critically evaluating the advantages and limitations of larval and adult fish tests, we suggest that zebrafish models become a rapidly emerging new field in modern molecular psychiatry research

    La tecnología móvil y su influencia en el estrés laboral del Banco BBVA Continental en el distrito del Callao, año 2016

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    La presente tesis tuvo como objetivo general, determinar la influencia de la tecnología móvil en el estrés laboral del banco BBVA Continental en el distrito del Callao, año 2016; la población objeto de investigación fue 161 colaboradores de la entidad financiera en cuestión, la muestra tiene el mismo número de colaboradores, considerándose de esta manera, una muestra censal; los datos fueron obtenidos mediante la técnica de encuesta y como instrumento un cuestionario el cual estuvo compuesto por 18 ítems, dicha información ha sido procesada utilizando el programa SPSS 21, logrando como resultado, que existe influencia significativa de la tecnología móvil en estrés laboral

    Dysfonctions somatiques du rachis cervical et traitement multi-attache : une étude transversale sur 145 sujets

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    Objectifs : Le but de cette étude transversale effectuée en aveugle est d’évaluer l’influence d’un appareil orthodontique fixe sur le rachis cervical. Matériels et méthodes : Le nombre et la gravité des dysfonctions somatiques (altération dans la fonction d’un élément constituant le système somatique ou DS) du rachis cervical ont été étudiés chez des patients classés en trois groupes : sujets sans traitement orthodontique (groupe 1), sujets portant un appareil orthodontique fixe (groupe 2) et sujets en contention après la dépose de l’appareil orthodontique fixe (groupe 3) et comparés grâce au test du khi2. Résultats : Un total de 145 patients âgés de 6 à 17 ans ont été inclus. Il y avait plus de DS dans le groupe 2 (p = 0,006) que dans le groupe 1. Il n’y avait pas de différence entre le groupe 1 et 3 (p = 0,2), entre le groupe 2 et 3 (p = 0,4) et entre les trois groupes (p = 0,6) concernant la sévérité des DS. Conclusion : Les troubles cervicaux ne devraient pas être imputés à long terme au traitement multi-attache puisqu’une fois le traitement orthodontique actif fini, les DS ne sont pas significativement augmentées par rapport au groupe contrôle. Ces résultats incitent à effectuer une étude pour évaluer le bénéfice d’un suivi ostéopathique des patients à risque après la pose de l’appareil multi-attache
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