Determination of effects of some pelletted straws on rumen pH and temperatures with wireless rumen sensors

Objective. This study was conducted with the aim of determination of the effects of pellets prepared with addition of different additives (molasses, guar meal and sepiolite) on changes in in vitro rumen pH and temperature. Materials and methods. In the current study sixteen pelleted feeds were prepared with wheat and soybean straws. The Daisy incubator was used for maintaining (mimicing) rumen conditions and feed was incubated for 48 hours. The wireless rumen sensors were used for determination of the changes in in vitro rumen pH and temperature. The data were subjected to one way variance analysis. Results. The tested boluses were found to show similar temperature and pH measurements to digital pH metre measurements. The effect of sepiolite addition on pH and temperature was found insignificant in all treatments. The lowest pH value was determined for wheat straws. Control groups and molasses added in soybean straws and wheat straws were similar in terms of ruminal pH values. Guar meal and guar meal+molasses added in soybean straws was shown to increase pH (p<0.01). In vitro rumen temperatures in soybean straws were found lower compared to those in wheat straws in all treatments (p<0.001). Conclusions. It was concluded that boluses integrated to Daisy incubator can be safely used for determining the effects of feeds on rumen fermentation in in vitro studies.Objetivo . Este estudio se realizó con el fin de determinar los efectos de los pellets preparados con adición de diferentes aditivos (melaza, harina de guar y sepiolita) sobre los cambios en el pH y temperatura in vitro del rumen. Materiales y métodos . En este estudio, se prepararon dieciséis alimentos peletizados con pajas de trigo y soya. La incubadora Daisy se usó para mantener (imitar) las condiciones del rumen y la alimentación se incubó durante 48 horas. Los sensores de rumen inalámbricos se usaron para la determinación de los cambios en el pH y la temperatura in vitro del rumen. Los datos fueron sometidos a análisis de varianza de una vía. Resultados . Se encontró que los bolos evaluados muestran mediciones de temperatura y pH similares a las mediciones del medidor de pH digital. El efecto de la adición de sepiolita sobre el pH y la temperatura fue insignificante en todos los tratamientos. El valor de pH más bajo se determinó para pajas de trigo. La adición de grupos de control y melazas en pajas de soya y paja de trigo fue similar en términos de valores de pH ruminal. Se demostró que la adición de harina de guar y harina de guar + melazas en pajas de soya aumenta el pH (p <0.01). Las temperaturas in vitro del rumen en las pajuelas de soya fueron menores en comparación con las pajas de trigo en todos los tratamientos (p <0.001). Conclusiones. Se concluyó que los bolos integrados a la incubadora Daisy se pueden utilizar de forma segura para determinar los efectos de los alimentos en la fermentación ruminal en estudios in vitro

The impact of oral anticoagulation on false lumen patency in acute type A aortic dissections

WOS: 000439420000001Background: In this study, the effect of postoperative oral anticoagulation on the false lumen patency of the distal aorta in patients with acute type A aortic dissection was investigated. Methods: Forty-one patients (32 male, 9 female; mean age 56.8 +/- 13.6 years; range, 30 to 84 years) who were diagnosed with acute type A aortic dissection and underwent surgical treatment in our clinic, and whose entire data of both control computed tomographic assessments and all postoperative follow-up visits could be accessed were enrolled. The patients were divided into two groups according to the type of surgical intervention that was performed. Computed tomography imaging of the patients were scanned and false lumen patency rates were evaluated. Besides oral anticoagulation, preoperative, intraoperative, and postoperative risk factors that may have affected false lumen patency secondary to acute type A aortic dissection were evaluated and statistically analyzed. Results: Twenty-one patients (51.2%) had concomitant hypertension. Thirty five (85.4%) of the patients had the main symptom of angina. Sixteen patients (39%) in Group 1 underwent ascending aortic replacement combined with aortic valve replacement (Bentall procedure); while 25 patients (61%) in Group 2 underwent isolated ascending aortic replacement. Mean follow-up was 43.9 +/- 26.3 (range: 5-120) months. No statistically significant difference was found between the study subgroups in any of the operation parameters except for cardiopulmonary bypass time (p=0.035) and cross-clamp time (p=0.002). Evaluation of the control contrast-enhanced tomographic imaging of the patients showed false lumen patency in the thorax in 34 patients (82.9%) and in the abdominal region in 33 patients (80.5%). When analyzing subgroups according to the type of surgical procedure, or indirectly anticoagulant use, no statistically significant difference was found in false lumen patency prevalence between the thoracic and abdominal groups (p=0.534 and p=0.922). Conclusion: No potential effect of postoperative anticoagulation on false lumen patency was found in cases with acute type A aortic dissection

Chronology of trace elements and radionuclides using sediment cores in Golden Horn Estuary, Sea of Marmara

Trace elements and radionuclides are substantial pollutants in marine environment since they are non-biodegradable and can be harmful even in minute concentrations. The Golden Horn estuary, where is an inlet of Bosphorus and two creeks, has been seriously polluted by untreated municipal and industrial dischargers for several decades. Since 1998, a large restoration and rehabilitation efforts have been undertaken in the estuary to mitigate the pollution. In the present study, four sediment cores were taken from the Golden Horn estuary to assess the historical accumulation of trace elements and radionuclides. Radiometric dating was implemented by 210Pb and 137Cs radionuclides and CRS model. Sedimentation rates were calculated in the range of 0.92–0.97 cm yr−1 in the estuary. The distribution of radionuclides (40K, 226Ra, and 228Ra) indicated some slight variations which ascribes to the geological characteristics of sediment along the cores. The concentrations of the anthropogenic elements were relatively higher in the intensive industrialization period. Their concentrations reduced in the latest 15–20 years thanks to the large-scale rehabilitation project in the estuary. The pollution indices, namely EF, Igeo, CF, and PLI showed that the concentrations of Cd, Cr, Cu, Pb, Sb, and Sn were above the world averages. Our results provide an insight on the long-term accumulation trends of trace element in the Golden Horn, which revealed that the estuary remains moderately polluted. We suggest that preventive countermeasures are much more important than post pollution remediation in the case of metallic pollution in the estuaries. © 2022 Elsevier Lt

Thalassemia-free and graft-versus-host-free survival: outcomes of hematopoietic stem cell transplantation for thalassemia major, Turkish experience

We report the national data on the outcomes of hematopoietic stem cell transplantation (HSCT) for thalassemia major (TM) patients in Turkey on behalf of the Turkish Pediatric Stem Cell Transplantation Group. We retrospectively enrolled 1469 patients with TM who underwent their first HSCT between 1988 and 2020 in 25 pediatric centers in Turkey. The median follow-up duration and transplant ages were 62 months and 7 years, respectively; 113 patients had chronic graft versus host disease (cGVHD) and the cGVHD rate was 8.3% in surviving patients. Upon the last visit, 30 patients still had cGvHD (2.2%). The 5-year overall survival (OS), thalassemia-free survival (TFS) and thalassemia-GVHD-free survival (TGFS) rates were 92.3%, 82.1%, and 80.8%, respectively. cGVHD incidence was significantly lower in the mixed chimerism (MC) group compared to the complete chimerism (CC) group (p < 0.001). In survival analysis, OS, TFS, and TGFS rates were significantly higher for transplants after 2010. TFS and TGFS rates were better for patients under 7 years and at centers that had performed over 100 thalassemia transplants. Transplants from matched unrelated donors had significantly higher TFS rates. We recommend HSCT before 7 years old in thalassemia patients who have a matched donor for improved outcomes

Dealing with the gray zones in the management of gastric cancer: The consensus statement of the Istanbul Group

The geographical location and differences in tumor biology significantly change the management of gastric cancer. The prevalence of gastric cancer ranks fifth and sixth among men and women, respectively, in Turkey. The international guidelines from the Eastern and Western countries fail to manage a considerable amount of inconclusive issues in the management of gastric cancer. The uncertainties lead to significant heterogeneities in clinical practice, lack of homogeneous data collection, and subsequently, diverse outcomes