761 research outputs found
Searching for keV Sterile Neutrino Dark Matter with X-ray Microcalorimeter Sounding Rockets
High-resolution X-ray spectrometers onboard suborbital sounding rockets can
search for dark matter candidates that produce X-ray lines, such as decaying
keV-scale sterile neutrinos. Even with exposure times and effective areas far
smaller than XMM-Newton and Chandra observations, high-resolution, wide
field-of-view observations with sounding rockets have competitive sensitivity
to decaying sterile neutrinos. We analyze a subset of the 2011 observation by
the X-ray Quantum Calorimeter instrument centered on Galactic coordinates l =
165, b = -5 with an effective exposure of 106 seconds, obtaining a limit on the
sterile neutrino mixing angle of sin^2(2 theta) < 7.2e-10 at 95% CL for a 7 keV
neutrino. Better sensitivity at the level of sin^2(2 theta) ~ 2.1e-11 at 95\%
CL for a 7 keV neutrino is achievable with future 300-second observations of
the galactic center by the Micro-X instrument, providing a definitive test of
the sterile neutrino interpretation of the reported 3.56 keV excess from galaxy
clusters.Comment: 13 pages, 13 figures, submitted to Ap
Observed Limits on Charge Exchange Contributions to the Diffuse X-ray Background
We present a high resolution spectrum of the diffuse X-ray background from
0.1 to 1 keV for a ~1 region of the sky centered at l=90, b=+60 using a
36-pixel array of microcalorimeters flown on a sounding rocket. With an energy
resolution of 11 eV FWHM below 1 keV, the spectrum's observed line ratios help
separate charge exchange contributions originating within the heliosphere from
thermal emission of hot gas in the interstellar medium. The X-ray sensitivity
below 1 keV was reduced by about a factor of four from contamination that
occurred early in the flight, limiting the significance of the results. The
observed centroid of helium-like O VII is 568+2-3 eV at 90% confidence. Since
the centroid expected for thermal emission is 568.4 eV while for charge
exchange is 564.2 eV, thermal emission appears to dominate for this line
complex, consistent with much of the high-latitude O VII emission originating
in 2-3 x 10^6 K gas in the Galactic halo. On the other hand, the observed ratio
of C VI Ly gamma to Ly alpha is 0.3+-0.2. The expected ratios are 0.04 for
thermal emission and 0.24 for charge exchange, indicating that charge exchange
must contribute strongly to this line and therefore potentially to the rest of
the ROSAT R12 band usually associated with 10^6 K emission from the Local Hot
Bubble. The limited statistics of this experiment and systematic uncertainties
due to the contamination require only >32% thermal emission for O VII and >20%
from charge exchange for C VI at the 90% confidence level. An experimental gold
coating on the silicon substrate of the array greatly reduced extraneous
signals induced on nearby pixels from cosmic rays passing through the
substrate, reducing the triggered event rate by a factor of 15 from a previous
flight of the instrument.Comment: 14 pages, 7 figures, to be published in Ap
Gene Constellation of Influenza A Virus Reassortants with High Growth Phenotype Prepared as Seed Candidates for Vaccine Production
BACKGROUND: Influenza A virus vaccines undergo yearly reformulations due to the antigenic variability of the virus caused by antigenic drift and shift. It is critical to the vaccine manufacturing process to obtain influenza A seed virus that is antigenically identical to circulating wild type (wt) virus and grows to high titers in embryonated chicken eggs. Inactivated influenza A seasonal vaccines are generated by classical reassortment. The classical method takes advantage of the ability of the influenza virus to reassort based on the segmented nature of its genome. In ovo co-inoculation of a high growth or yield (hy) donor virus and a low yield wt virus with antibody selection against the donor surface antigens results in progeny viruses that grow to high titers in ovo with wt origin hemagglutinin (HA) and neuraminidase (NA) glycoproteins. In this report we determined the parental origin of the remaining six genes encoding the internal proteins that contribute to the hy phenotype in ovo. METHODOLOGY: The genetic analysis was conducted using reverse transcription-polymerase chain reaction (RT-PCR) and restriction fragment length polymorphism (RFLP). The characterization was conducted to determine the parental origin of the gene segments (hy donor virus or wt virus), gene segment ratios and constellations. Fold increase in growth of reassortant viruses compared to respective parent wt viruses was determined by hemagglutination assay titers. SIGNIFICANCE: In this study fifty-seven influenza A vaccine candidate reassortants were analyzed for the presence or absence of correlations between specific gene segment ratios, gene constellations and hy reassortant phenotype. We found two gene ratios, 6:2 and 5:3, to be the most prevalent among the hy reassortants analyzed, although other gene ratios also conferred hy in certain reassortants
Organizational factors and depression management in community-based primary care settings
Abstract Background Evidence-based quality improvement models for depression have not been fully implemented in routine primary care settings. To date, few studies have examined the organizational factors associated with depression management in real-world primary care practice. To successfully implement quality improvement models for depression, there must be a better understanding of the relevant organizational structure and processes of the primary care setting. The objective of this study is to describe these organizational features of routine primary care practice, and the organization of depression care, using survey questions derived from an evidence-based framework. Methods We used this framework to implement a survey of 27 practices comprised of 49 unique offices within a large primary care practice network in western Pennsylvania. Survey questions addressed practice structure (e.g., human resources, leadership, information technology (IT) infrastructure, and external incentives) and process features (e.g., staff performance, degree of integrated depression care, and IT performance). Results The results of our survey demonstrated substantial variation across the practice network of organizational factors pertinent to implementation of evidence-based depression management. Notably, quality improvement capability and IT infrastructure were widespread, but specific application to depression care differed between practices, as did coordination and communication tasks surrounding depression treatment. Conclusions The primary care practices in the network that we surveyed are at differing stages in their organization and implementation of evidence-based depression management. Practical surveys such as this may serve to better direct implementation of these quality improvement strategies for depression by improving understanding of the organizational barriers and facilitators that exist within both practices and practice networks. In addition, survey information can inform efforts of individual primary care practices in customizing intervention strategies to improve depression management.http://deepblue.lib.umich.edu/bitstream/2027.42/78269/1/1748-5908-4-84.xmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78269/2/1748-5908-4-84-S1.PDFhttp://deepblue.lib.umich.edu/bitstream/2027.42/78269/3/1748-5908-4-84.pdfPeer Reviewe
The Microcalorimeter Arrays for a Rhenium Experiment (MARE): a next-generation calorimetric neutrino mass experiment
Neutrino oscillation experiments have proved that neutrinos are massive
particles, but can't determine their absolute mass scale. Therefore the
neutrino mass is still an open question in elementary particle physics. An
international collaboration is growing around the project of Microcalorimeter
Arrays for a Rhenium Experiment (MARE) for directly measuring the neutrino mass
with a sensitivity of about 0.2eV/c2. Many groups are joining their experiences
and technical expertise in a common effort towards this challenging experiment.
We discuss the different scenarios and the impact of MARE as a complement of
KATRIN.Comment: 3 pages, 1 figure Nucl. Instr. Meth. A, proceedings of LTD11
workshop, Tokyo 200
Accelerator experiments with soft protons and hyper-velocity dust particles: application to ongoing projects of future X-ray missions
We report on our activities, currently in progress, aimed at performing
accelerator experiments with soft protons and hyper-velocity dust particles.
They include tests of different types of X-ray detectors and related components
(such as filters) and measurements of scattering of soft protons and
hyper-velocity dust particles off X-ray mirror shells. These activities have
been identified as a goal in the context of a number of ongoing space projects
in order to assess the risk posed by environmental radiation and dust and
qualify the adopted instrumentation with respect to possible damage or
performance degradation. In this paper we focus on tests for the Silicon Drift
Detectors (SDDs) used aboard the LOFT space mission. We use the Van de Graaff
accelerators at the University of T\"ubingen and at the Max Planck Institute
for Nuclear Physics (MPIK) in Heidelberg, for soft proton and hyper-velocity
dust tests respectively. We present the experimental set-up adopted to perform
the tests, status of the activities and some very preliminary results achieved
at present time.Comment: Proceedings of SPIE, Vol. 8443, Paper No. 8443-24, 201
Modeling a Three-Stage SQUID System in Space with the First Micro-X Sounding Rocket Flight
The Micro-X sounding rocket is a NASA funded X-ray telescope payload that
completed its first flight on July 22, 2018. This event marked the first
operation of Transition Edge Sensors (TESs) and their SQUID-based multiplexing
readout system in space. Unfortunately, due to an ACS pointing failure, the
rocket was spinning during its five minute observation period and no scientific
data was collected. However, data collected from the internal calibration
source marked a partial success for the payload and offers a unique opportunity
to study the response of TESs and SQUIDs in space. Of particular interest is
the magnetic field response of the NIST MUX06a SQUID readout system to tumbling
through Earth's magnetic field. We present a model to explain the baseline
response of the SQUIDs, which lead to a subset of pixels failing to "lock" for
the full observational period. Future flights of the Micro-X rocket will
include the NIST MUX18b SQUID system with dramatically reduced magnetic
susceptibility.Comment: 6 pages, 6 figures, LTD19 conference proceeding
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