Direct Phosphonation of Quinolinones and Coumarins Driven by the Photochemical Activity of Substrates and Products

Light-promoted phosphonation of quinolinones and coumarins was developed without the need for an external photocatalyst. Investigations support a mechanism whereby both starting materials and products act as photosensitizers upon excitation using compact fluorescent light sources to photochemically promote the dissociation of the N–O bond in the pyridinium salt by a single electron transfer pathway. A wide range of quinolinone and coumarin substrates can be utilized in the phosphonation process under mild reaction conditions

Ru(II)-Catalyzed Site-Selective Hydroxylation of Flavone and Chromone Derivatives: The Importance of the 5‑Hydroxyl Motif for the Inhibition of Aurora Kinases

An efficient protocol for Ru­(II)-catalyzed direct C–H oxygenation of a broad range of flavone and chromone substrates was developed. This convenient and powerful synthetic tool allows for the rapid installation of the hydroxyl group into the flavone, chromone, and other related scaffolds and opens the way for analog synthesis of highly potent Aurora kinase inhibitors. The molecular docking simulations indicate that the formation of bidentate H-bonding patterns in the hinge regions between the 5-hydroxyflavonoids and Ala213 was the significant binding force, which is consistent with experimental and computational findings

Appendix C. Modeling trends in recruitment since the start of the epizootic.

Modeling trends in recruitment since the start of the epizootic

Appendix E. Elasticity and perturbation analyses.

Elasticity and perturbation analyses

Appendix B. Estimating storm-related mortality of large colonies.

Estimating storm-related mortality of large colonies

Appendix D. Estimating the size-dependence of infection risk during the early epizootic.

Estimating the size-dependence of infection risk during the early epizootic

Appendix A. Estimating height–area relationships.

Estimating height–area relationships